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Chris Burd, Ph.D.
Associate
Professor, Dept of Cell and Developmental Biology
Cell Biology
and Physiology Program
Address
1010 Biomed Rsch Bldg (BRB) II/III (Office)
1027 Biomed Rsch Bldg (BRB) II/III (Lab)
421 Curie Boulevard
Philadelphia, PA 19104-6140
Office tel.: 215 573-5158
Lab tel.: 215 573-5159
Fax: 215 898-9240
E-mail: cburd@mail.med.upenn.edu
Link
Cell
and Developmental Biology faculty page
Education
Wake Forest University: BA (Biology), 1985.
Northern Illinois University: MS (Molecular Biology), 1987.
Northwestern University: PhD (Cell and Molecular Biology),
1994.
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Research Interests
- ARF GTPases, Rab GTPases, endocytosis, secretion,
phosphatidylinositol kinase signaling.
Key words:ARF
GTPases, Rab GTPases, endocytosis, secretion, phosphatidylinositol
kinase signaling.
Description of Research
Our lab is interested in understanding how proteins
and lipids are sorted to different organelles within the cell.
Investigation of the molecular sorting mechanisms responsible
for the biogenesis and maintenance intracellular organelles
has been a central problem in cell biology for many years,
and research in the field has provided many insights into
human disease. We currently focus on two aspects of molecular
sorting:
- Regulation by phosphoinositides:
Phosphatidylinositol (PtdIns) is a lipid component of all
cellular membranes that has important regulatory functions.
PtdIns can be phosphorylated by phosphatidylinositol kinases
at several different positions on the lipid head group and
each phosphorylated form (collectively called phosphoinositides)
appears to regulate different cellular pathways, including
sorting of proteins in the endosomal pathway, apoptosis,
and the cytoskeleton. One major interest of the lab is to
identify phosphoinositide-binding proteins and to learn
how they link phosphorylation of PtdIns to molecular sorting
events.
- Regulation by small GTPases of the Rab and
ARF family:
Signaling by Ras-related GTPases of the ARF and Rab families
regulate biogenesis and trafficking of transport vesicles
between different organelles. Cells express a family of
ARF and Rab GTPases and each is localized distinctly within
the cell. We are trying to understand the molecular events
regulated by ARF and Rab signaling and we are also trying
figure out different ARFs and Rabs are localized to distinct
organelles.
Selected Publications
Liu, J., Schmitz, K.R., Li, S., Setty, T.G.,
Wood, C.S., Ferguson, K.M., and Burd, C.G., 2008. Golgi localization
of glycosyltransferases requires a Vps74 oligomer. 2008.
Dev. Cell., 14:523-534.
Strochlic, T.I., Setty, T.G., S.A., Sitaram,
A., and Burd, C. G., 2007. Grd19/Snx3p functions as a cargo-specific
adapter for retromer-dependent endocytic recycling., J.Cell
Biol., 177:115-125.
Liu, J., Sitaram, A., and Burd, C. G., 2007.
Regulation of endocytosis and degradation of the yeast copper
transporter, Ctr1p, by the Rsp5 ubiquitin ligase., Traffic,
8:1375-1384.
Gangi Setty, S.R., Strochlic, T. Tong, A.H.Y.,
Boone, C., and Burd, C.G. 2004. Golgi targeting of ARF-like
GTPase Arl3p requires its Na acetylation and the integral
membrane protein Sys1p. Nature Cell Biology, 6:414-419.
Gangi Setty, S.R., Shin, M.E., Yoshino, A.,
Marks, M.S., . and Burd C.G., 2003. Golgi Recruitment of GRIP
Domain Proteins by ARF-like GTPase1 is Regulated by ARF-like
GTPase 3. Curr. Biol., 13:401-404.
Search PubMed for more articles
Lab
Rotation Projects
A variety of rotation projects to investigate protein and lipid sorting and trafficking in secretory and endosomal pathways are available. Individual projects will be tailored for each student with regard to research interest and experience.
- Lab Personnel:
Jingxuan Liu graduate student
Dr. Chris Wood postdoctoral fellow
Annika Khine undergraduate researcher
last updated 8/2008
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