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Chris Burd
Assistant Professor, Dept of Cell and Developmental Biology
Cell Biology
and Physiology Program
Address
1010 Biomed Rsch Bldg (BRB) II/III (Office)
1027 Biomed Rsch Bldg (BRB) II/III (Lab)
421 Curie Boulevard
Philadelphia, PA 19104-6140
Office tel.: 215 573-5158
Lab tel.: 215 573-5159
Fax: 215 898-9240
E-mail: cburd@mail.med.upenn.edu
Link
Cell
and Developmental Biology faculty page
Education
Wake Forest University: BA (Biology), 1985.
Northern Illinois University: MS (Molecular Biology), 1987.
Northwestern University: PhD (Cell and Molecular Biology),
1994.
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Research Interests
ARF GTPases, Rab GTPases, endocytosis, secretion,
phosphatidylinositol kinase signaling.
Key words: ARF
GTPases, Rab GTPases, endocytosis, secretion, phosphatidylinositol
kinase signaling.
Search PubMed for articles
Description of Research
Our lab is interested in understanding how proteins
and lipids are sorted to different organelles within the cell.
Investigation of the molecular sorting mechanisms responsible
for the biogenesis and maintenance intracellular organelles
has been a central problem in cell biology for many years,
and research in the field has provided many insights into
human disease. We currently focus on two aspects of molecular
sorting:
- Regulation by phosphoinositides:
Phosphatidylinositol (PtdIns) is a lipid component of all
cellular membranes that has important regulatory functions.
PtdIns can be phosphorylated by phosphatidylinositol kinases
at several different positions on the lipid head group and
each phosphorylated form (collectively called phosphoinositides)
appears to regulate different cellular pathways, including
sorting of proteins in the endosomal pathway, apoptosis,
and the cytoskeleton. One major interest of the lab is to
identify phosphoinositide-binding proteins and to learn
how they link phosphorylation of PtdIns to molecular sorting
events.
- Regulation by small GTPases of the Rab and
ARF family:
Signaling by Ras-related GTPases of the ARF and Rab families
regulate biogenesis and trafficking of transport vesicles
between different organelles. Cells express a family of
ARF and Rab GTPases and each is localized distinctly within
the cell. We are trying to understand the molecular events
regulated by ARF and Rab signaling and we are also trying
figure out different ARFs and Rabs are localized to distinct
organelles.
Recent Publications
Liu, J., Sitaram, A., and Burd, C. G.
(2007). Regulation of endocytosis and degradation of the
yeast copper transporter, Ctr1p, by the Rsp5 ubiquitin ligase.
Traffic, in press.
Strochlic, T.I., Setty, T. G., S. A. Sitaram,
A., and Burd, C.G. (2007). Grd 19/Snx3p functions
as a cargo-specific adapter for retromer-dependent endocytic
recycling. J. Cell. Biol. 177, 115-125.
Geng, J., Shin, M. E., Gilbert, P., Collins,
R.N., Burd, C.G.: Yeast Rab-GDI Displacement
Factor ortholog, Yip3p, forms distinct complexes with the
Ypt1p Rab GTPase and the reticulon, Rtn1p. Euk. Cell,
4:1166-1174.
Forgacs, G. Yook, S.Y., Janmey, P.A., Jeong,
H., and Burd, C.G., 2004. Role of the cytoskeleton
in signaling networks. J. Cell Sci., 117:2769-2775.
Gangi Setty, S.R., Strochlic, T. Tong, A.H.Y.,
Boone, C., and Burd, C.G. 2004. Golgi targeting
of ARF-like GTPase Arl3p requires its N± acetylation
and the integral membrane protein Sys1p. Nature Cell Biology,
6:414-419.
Lab
Rotation Projects
Please discuss with Dr. Burd.
- Personnel:
- Todd Strichlic, graduate student
Jingxuan Liu, graduate student
last updated 8/2007
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