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Peter
F Davies, Ph.D.
Robinette Foundation Professor of Cardiovascular Medicine,
Dept of Pathology & Laboratory Medicine
Cell
Biology and Physiology Program
Address
1010 Vagelos Bldg
3340 Smith Walk
Philadelphia, PA 19104-6383
Office tel.: 215 573 6813
Lab tel.: 215 898 0418
Fax: 215 573 6815
E-mail: pfd@pobox.upenn.edu
Link(s)
Dr. Davies's
Institute for Medicine and Engineering Page
EDUCATION
University of Newcastle upon Tyne: BS (Biochemistry), 1969.
Univesity of Victoria: MSc (Biochemistry), 1972.
University of Cambridge: PhD (Experimental Pathology), 1975.
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Research Interests
- Biomechanics in Vascular Biology/Pathology, Hemodynamics
and Atherosclerosis, Vascular Cell Communication, Cytoskeletal
and membrane biophysics.
Key
words: Endothelium, hemodynamic
forces, atherosclerosis, vascular biology, vascular pathology,
endothelial mechanotransduction, shear stress, endothelial
genomics.
Search PubMed for articles
Description of Research
Molecular mechanisms of cardiovascular diseases, particularly
arterial biology and pathology (atherosclerosis). Mechanisms
of interaction of hemodynamic forces with the vascular endothelium
and vascular cell-cell interactions. Experimental approaches
ranging from cell and molecular biology, membrane biophysics,
to biomechanics andcomputational fluid dynamics.
Recent Publications
Davies, P.F. (2007). Hemodynamics in the determination of
the endothelial phenotype and flow mechanotransduction. In:
'Endothelial Biomedicine; A Comprehensive Treatise', Ed. Aird,.W.C.
Cambridge University Press. 220-235
Fang Y., Mohler E., Hsieh E., Osman H., Hashemi S., Davies,
P.F., Rothblat G.H., Wilensky R. Levitan I. 2006.
Hypercholesterolemia suppresses Kir channels in aortic endothelium
in vitro and in vivo. Circ. Research.
98, 1064-1071.
Magid, R., Davies, P.F. (2005). Endothelial
protein kinase C isoform identity and differential activity
of PKCz in an athero-susceptible region of porcine aorta.
Circ. Research. 97, 443-449.
Simmons, C.A, Manduchi, E., Grant, G., Davies, P.F.
(2005). Spatial heterogeneity of endothelial phenotypes correlates
with side-specific vulnerability to calcification in normal
porcine aortic valves. Circ. Research. 96, 792-799.
Passerini, A.G., Polacek, D.C., Shi, C., Francesco, N.M.,
Manduchi, E., Grant, G., Pritchard, W.P., Powell, S.J., Chang,
G., Stoeckert, C., and Davies, P.F. (2004).
Coexisting pro-inflammatory and anti-oxidative endothelial
transcription profiles in a disturbed flow region of the adult
porcine aorta. Proc. Natl. Acad. Sci. USA 101, 2482-2487.
LAB
Rotation Projects:
Flow and regulation of microRNA genes in arterial endothelial cells
Computational simiulations of vascular hemodynamics applied to stent
design and experimental testing (suit a computational/physics/engineering background)
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Lab Personnel:
- Yun Fang PhD (Penn), Postdoctoral Fellow
Juan Jimenez PhD (Princeton), Postdoctoral Fellow
Mete Civelek MS, Graduate Student (Bioeng)
Armen Kramanian MD, Graduate Student (Pharmacol)
Marie Guerraty, Graduate Student (MD-PhD, Bioeng)
Congzhu Shi PhD, Technical Staff
Chrysta Irolla, Student Intern
Amanda Bridges, Student Intern
last updated 7/2007
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