E. Michael Ostap
Associate Professor, Depts of Physiology, Pennsylvania Muscle Institute

Cell Biology and Physiology Program

Mailing Address

B400 Richards Building
3700 Hamilton Walk
Philadelphia, PA 19104-6085

Lab

B40 Anatomy-Chemistry
3620 Hamilton Walk
Phjiladelphia, PA 19104

Office tel.: 215 573-9758
Lab tel.: 215 898-3685
Fax: 215 573-1171
E-mail: ostap@mail.med.upenn.edu

Link(s)

Ostap Laboratory at the PA Muscle Institute

EDUCATION

Illinois State University: BS (Chemistry), 1988.

University of Minnesota School of Medicine: PhD (Biochemistry, Biophysics, and Molecular Biology), 1993.

Johns Hopkins School of Medicine: Post-doctoral fellow (Cell Biology), 1997.

RESEARCH INTERESTS

• Molecular mechanisms of cell motility

Key words: Cell motility, cancer, myosin, actin, biochemistry, cell culture, spectroscopy, microscopy, fluorescence.

Search PubMed for articles

DESCRIPTION OF RESEARCH

The goal of our research is to understand the molecular mechanisms of cell motility, which include: cell migration, regulation of cell shape and extracellular attachment, and intracellular transport. Cell motility is crucial for several normal and pathological processes, including: cell and tissue development, endocytosis, wound healing, immune response, and metastases of tumors.

RECENT PUBLICATIONS

T. Lin, N. Tang, and E.M. Ostap. (2005). Biochemical and motile properties of myo1b splice isoforms. J. Biol. Chem. 280,41562-41567

D.E. Hokanson and E.M. Ostap. (2006). Myo1c binds tightly and specifically to PIP2 and InsP3. Proc. Natl. Acad. Sci (USA). 103,3118-3123.

D.E. Hokanson, J.M. Laakso, T. Lin, D. Sept, and E.M. Ostap. (2006). Myo1c Binds Phosphoinositides through a Putative PH domain. Mol. Biol. Cell. 17,4856-4865.

J.H. Lewis, T. Lin, D.E. Hokanson, and E.M. Ostap. (2006). Temperature Dependence of Nucleotide Association and Kinetic Characterization of Myo1b. Biochemistry 45:11589-11597.

E.M. De La Cruz and E.M. Ostap. (2007). Actin. In Cells, Edited by Benjamin Lewin, Jones and Bartlett

Lab

ROTATION PROJECTS

For up-to-date rotation projects, please see the Ostap Laboratory Website

PERSONNEL