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Britton
Chance, Ph.D., Sc.D. (Cantab.), M.D. (Hon)
Eldridge Reeves Johnson University
Professor Emeritus of Biophysics, Dept of Biochemistry &
Biophysics
Cancer Biology Program
Address
250 Anatomy-Chemistry Building
3620 Hamilton Walk
Philadelphia, PA 19104-6059
Office tel.: 215 898-7159, 4342
Lab tel.: 215 898-4387, 898-3296,573-3212, 746-0080, 746-0081
Fax: 215 898-1806
E-mail: chance@mail.med.upenn.edu
Links
Dr.
Chance's Biochemistry & Biophysics Page
Dr.
Chance's Biochemistry & Molecular Biophysics Graduate
Group Page
Education
University of Pennsylvania: BS (Chemistry), 1935.
University of Pennsylvania: MS (Chemistry), 1936.
University of Pennsylvania: PhD (Physical Chemistry), 1940.
Cambridge University: PhD (Biology "B", Physiology),
1942.
Cambridge University: DSc (Biology "B", Physiology),
1952.
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Research Interests
- cancer detection: angiogenesis, hypermetabolism, molecular
beacons, high resolution diagnostic cryoimaging, home care
detectors.
- cognitive imaging: metabolic responses, deceit, malevolence,
hemodynamic response measured by NIR imaging.
- skeletal muscle function: oxygenation, blood volume in
exercise; olympic athletes, geriatrics, and mitochondrial
and vascular diseases.
- cardiac hypoxia: transthoracic myocardial oxygenation.
- computer simulation of heterogeneity of cancer.
Key
words: peroxidases, cytochromes,
dehydrogenases, skeletal muscle, exercise performance, prefrontal
cortex, learning, emotional stress, dual wavelength spectroscopy,
electron tunneling, Phosphorus NMR spectroscopy, NIR spectroscopy
and imaging, NADH, flavoprotein, molecular beacons, fetal
brain in utero, cardiac muscle trans-thoracic, metabolomics.
Description of Research
Dr. Chance's research interests cover a manifold of biochemical,
biophysical and medical topics beginning with the discovery
of the enzyme substrate compounds of peroxidase and the mechanical
differential analyzer solutions of the Michaelis-Menten equations.
He branched out into a wide range of studies of enzyme substrate
compounds of catalases and peroxidases and, with an ingenious
optical method, the discovery of the NADH and flavin components
of the respiratory chain together with the observation of
multi-site respiratory control and quantum mechanical electron
tunneling in the photosynthetic reaction center. The studies
were carried out not only in vitro but in vivo (e.g. online
human brain redox monitoring in the operating room) and formed
the basis for the development of sensitive spectrophotometric
methods at room and low temperatures for studying biological
systems. The Chance dual wavelength spectrophotometer is still
in widespread use. Early studies of NMR progressed from hedgehog
brain to human leg (the first human subject NMR studies, using
a 1.5T magnet) and thereafter to such applications as diagnosis
and treatment of mitochondrial disease and 31P NMR of human
neonate neuroblastoma in situ using PME as an indicator of
tumor growth or regression. These studies led to the development
of near infrared (NIR) spectroscopy and imaging for real time
metabolic studies of brain (hematoma detection, prefrontal
cortex monitoring, fetal brain oxygenation in utero), breast
(cancer detection using signals of angiogenesis and hypermetabolism),
skeletal muscle (metabolic monitoring) and cardiac muscle
(trans-thoracic detection of hypoxia of myocardium). Many
of these studies are ongoing, particularly PFC monitoring
during cognition, stress, and deception; and early detection
of breast cancer using simple, economical, portable and handheld
devices. New fields of research include development and use
of high resolution 2- and 3D cryoimaging using molecular beacons
for detection of heterogeneity in tumors, and monitoring the
effects of cancer treatments including photodynamic therapies.
Selected Publications
Chance B, Nioka S, Zhang J, Conant EF, Hwang E, Briest S,
Orel SG, Schnall MD, Czerniecki BJ. Breast cancer detection
based on incremental biochemical and physiological properties
of breast cancers: A six year, two site study. Acad Radiol.
2005; In press.
Choe R, Corlu A, Lee K, Durduran T, Konecky SD, Grosicka-Koptyra
M, Arridge SR, Czerniecki BF, Fraker DL, DeMichele A, Chance
B, Rosen MA, Yodh AG. Diffuse optical tomography of breast
cancer during neoadjuvant chemotherapy: A case study with
comparison to MRI. Med. Phys. 2005; 32(4):1128-1139.
Zheng G, Chen Y, Intes X, Chance B, Glickson JD. Contrast-enhanced
near-infrared (NIR) optical imaging for subsurface cancer
detection. J Porphyrins Phthalocyanines 2004; 8:1106-1117.
Chance B. Mitochondrial NADH redox state, monitoring discovery
and deployment in tissue. Methods Enzymol. 2004;385:361-70.
Chen Y, Zheng G, Zhang ZH, Blessington D, Zhang M, Li H,
Liu Q, Zhou L, Intes X, Achilefu S, Chance B. Metabolism-enhanced
tumor localization by fluorescence imaging: in vivo animal
studies. Opt Lett. 2003 Nov 1;28(21):2070-2.
Search PubMed for more articles
Lab
Rotation Projects
- Molecular beacons in detection of cancer.
- Imaging of cortical function in problem solving, emotional
distress, deceit, etc.
- Technical development particularly NIR optical spectroscopy
and imaging.
- Lab
personnel:
Huang, Ping: Ph.D., Postdoctoral Fellow
Busch , David: Ph.D. Student
Im, Joohee: Ph.D. Student
Ranji, Mahsa: Ph.D. Student
Wang, Xin: Ph.D. Student
Xing, Ye: Ph.D. Student
Zhou, Lanlan: Ph.D. Student
Du, Juan: B.S., Research Technician
Lech, Gwen M.: B.S., Research Technician
Zhang, Jun: M.S., Research Technician
Zhao, Zhongyao: M.S., Research Technician
Zhong, Tuoxiu: M.S., Research Technician
last updated 6/2005
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