CAMB: Faculty: Lewis A. Chodosh, M.D., Ph.D.

Lewis A. Chodosh, M.D., Ph.D.
Professor and Interim Chair, Department of Cancer Biology
Associate Director for Basic Science, Abramson Cancer Center
Director, Cancer Genetics, Abramson Family Cancer Research Institute
Program Leader, Breast Cancer Program, Abramson Cancer Center
Professor of Cancer Biology, Cell & Developmental Biology, and Medicine

Cancer Biology Program

Address

612 Biomedical Rsch Bldg (BRB) II/III
421 Curie Boulevard
Philadelphia, PA 19104-6160
Lab Address: 624-630 BRB II/III

Office tel.: 215 898-1321
Lab tel.: 215 898-0006
Fax: 215 573-6725
E-mail: chodosh@mail.med.upenn.edu

Assistant Contact Information:

Judith A. Farrell
616 Biomedical Research Building II/III
phone: 215-573-3224
E-mail: jufarrel@mail.med.upenn.edu

Link(s)

Lewis A. Chodosh at the Abramson Institute

EDUCATION

Yale University: BS (Molecular Biophysics & Biochemistry), 1981.

Massachusetts Institute of Technology: PhD (Transcription Factor Biochemistry), 1988.

Harvard Medical School: MD, 1989.

Research Interests

Genetically engineered mouse models for breast cancer initiation, metastasis, and recurrence.
Normal developmental biology of the mammary gland.
Tumor dormancy.
Stem cells in breast cancer and mammary development.
Oncogenes and tumor suppressors in breast cancer.
Genomics and computational biology.
Non-invasive imaging.

Key words: Mouse models, cancer, development, genomics, stem cells, imaging, oncogenes, targeted therapy.

Description of Research

Breast cancer is the most common cancer as well as the leading cause of death from cancer among women worldwide. The Chodosh laboratory uses genetically engineered mouse models to study the genes and mechanisms that cause breast cancer and that regulate normal mammary gland development. Particular areas of interest include: the function of oncogenes and tumor suppressor genes in breast cancer, metastasis, tumor dormancy and recurrence; the role of stem cells in cancer and the normal development of the mammary gland; the use of genomics and computational approaches to understand genetic programs in mammary development and breast cancer; the mechanisms by which pregnancy protects against breast cancer; and the use of non-invasive imaging approaches such as PET, MRI, and bioluminescence to study tumor biology. These approaches employ a broad array of molecular, cellular, animal, human, and in silico model systems to study the function of key regulatory molecules in mammary gland and tumor biology.

Selected Publications

Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero C, Sterner CJ, Notorfrancesco K, Cardiff RD, and Chodosh LA. 2005. The transcriptional repressor, Snail, promotes mammary tumor recurrence. Cancer Cell 8:197-209.

Blakely CM, Stoddard AJ, Belka GK, Dugan KD, Notarfrancesco KL, Moody SE, D Cruz CM, and Chodosh LA. 2006. Hormone-induced protection against mammary tumorigenesis is conserved in multiple rat strains and identifies a core gene expression signature induced by pregnancy.Cancer Research, 66:6421-6431.

Wang M, Master SR, and Chodosh LA. 2006. Computational expression deconvolution in a complex mammalian organ. BMC Bioinformatics, 7:328-341.

Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portacarrero CP, Keister BA, Belka GK, Cho H, Rathmell J, Thompson CB, Birnbaum MJ, and Chodosh LA. 2006. Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metabolism, 4:475-490.

Sarkisian CJ, Keister BA, Stairs DB, Boxer RB, Moody SE, and Chodosh LA. 2007. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nature Cell Biology, 9:493-505.

Search PubMed for more articles

Lab

Rotation Projects

Rotation projects are available in each of the main areas of the lab.

Lab personnel:

last updated 9/2008

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