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Lewis
A. Chodosh, M.D., Ph.D.
Associate Professor, Depts of Cancer Biology, Cell & Developmental
Biology, and Medicine
Director, Cancer Genetics, Abramson Family Cancer Research
Institute
Vice Chair, Department of Cancer Biology Program Leader, Breast
Cancer Research Program
Co-Director, UPENN Small Animal Imaging Facility
Cancer Biology Program
Address
612 Biomedical Rsch Bldg (BRB) II/III
421 Curie Boulevard
Philadelphia, PA 19104-6160
Lab Address: 624-630 BRB II/III
Office tel.: 215 898-1321
Lab tel.: 215 898-0006
Fax: 215 573-6725
E-mail: chodosh@mail.med.upenn.edu
Assistant
Contact Information:
Judith
A. Farrell
616 Biomedical Research Building II/III
phone: 215-573-3224 E-mail:
jufarrel@mail.med.upenn.edu
Link(s)
Lewis
A. Chodosh at the Abramson Institute
EDUCATION
Yale University: BS (Molecular Biophysics & Biochemistry),
1981.
Massachusetts Institute of Technology: PhD (Transcription
Factor Biochemistry), 1988.
Harvard
Medical School: MD, 1989.
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RESEARCH
INTERESTS
- Genetically engineered mouse models for breast cancer
initiation, metastasis, and recurrence.
- Normal developmental biology of the mammary gland.
- Tumor dormancy.
- Stem cells in breast cancer and mammary development.
- Oncogenes and tumor suppressors in breast cancer.
- Genomics and computational biology.
- Non-invasive imaging.
Key
words: Mouse models, cancer, development,
genomics, stem cells, imaging, oncogenes, targeted therapy.

Search PubMed for articles
DESCRIPTION
OF RESEARCH
Breast cancer is the most common cancer as well as the leading
cause of death from cancer among women worldwide. The Chodosh
laboratory uses genetically engineered mouse models to study
the genes and mechanisms that cause breast cancer and that
regulate normal mammary gland development. Particular areas
of interest include: the function of oncogenes and tumor suppressor
genes in breast cancer, metastasis, tumor dormancy and recurrence;
the role of stem cells in cancer and the normal development
of the mammary gland; the use of genomics and computational
approaches to understand genetic programs in mammary development
and breast cancer; the mechanisms by which pregnancy protects
against breast cancer; and the use of non-invasive imaging
approaches such as PET, MRI, and bioluminescence to study
tumor biology. These approaches employ a broad array of molecular,
cellular, animal, human, and in silico model systems
to study the function of key regulatory molecules in mammary
gland and tumor biology.
RECENT
PUBLICATIONS
Gunther EJ, Moody SE, Belka GK, Hahn KT, Innocent N, Dugan
KD, Cardiff RD, and Chodosh LA. Impact of p53 loss on reversal
and recurrence of conditional Wnt-induced tumorigenesis. Genes
& Development, 17:488-501, 2003.
Boxer RB, Jang JW, Sintasath L, and Chodosh LA. Lack of sustained
regression of c-MYC-induced mammary adenocarcinomas following
brief or prolonged MYC inactivation. Cancer Cell,
6:577-586, 2004.
Chodosh LA. Modeling human cancers in mice. Cancer Biology
& Therapy, 4:255-256, 2005.
Master SR, Stoddard AJ, Bailey LC, Pan TC, Dugan KD, and
Chodosh LA. Genomic analysis of early murine mammary gland
development using novel probe-level algorithms. Genome
Biology, 6, 2005.
Blakely CM, Sintasath L, D'Cruz CM, Master SR, Hahn KT, Belka
GK, and Chodosh LA. Developmental stage determines the effects
of c-MYC in the mammary epithelium. Development,
1132:1147-1160, 2005.
Moody SE, Prez D, Pan TC, Sarkisian CJ, Portocarrero C, Sterner
CJ, Notorfrancesco K, Cardiff RD, and Chodosh LA. The transcriptional
repressor, Snail, promotes mammary tumor recurrence. Cancer
Cell, 8:197-209, 2005.
Lab
ROTATION
PROJECTS
Rotation projects are available in each of the main areas
of the lab.
- Lab
personnel:
- James Alvarez, Ph.D. - Postdoctoral Fellow
Charles Bailey, M.D., Ph.D. - Instructor
Suzanne Bakewell, Ph.D. - Postdoctoral Fellow
Collin Blakely - Graduate Student
Chien-chung Chen, Ph.D. - Postdoctoral Fellow
Joanne Jang - Graduate Student
Isabel Latorre, Ph.D. - Postdoctoral Fellow
Congzhou Liu - Graduate Student
Denise Perez, Ph.D. - Postdoctoral Fellow
Haoqun Qiu, Ph.D. - Postdoctoral Fellow
Patrick Taulman, Ph.D. - Postdoctoral Fellow
Min Wang, Ph.D. - Postdoctoral Fellow
Minghua Xu, Ph.D. - Postdoctoral Fellow
Xiaoping Yang, Ph.D. - Postdoctoral Fellow
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last updated 11/2005
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