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Margaret
M. Chou
Assistant Professor, Dept of Cell and Developmental Biology
Cancer Biology Program
Address
1011 Biomedical Rsch Bldg II/III (Office)
1032 Biomedical Rsch Bldg II/III (Lab)
421 Curie Boulevard
Philadelphia, PA 19104
Office tel.: 215 573-4126
Lab tel.: 215 573-4127
Fax: 215 898-9871
E-mail: mmc@mail.med.upenn.edu
Link(s)
Dr.
Chou's Cell & Developmental Biology Page
EDUCATION
Barnard College: BA (Biochemistry), 1987.
Rockefeller University: PhD (Molecular Oncology), 1993.
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RESEARCH
INTERESTS
- mechanisms of malignant transformation
- signaling by small GTPases
- regulation of vesicular trafficking
- ubiquitination
Key
words: G proteins, transformation,
trafficking, ubiquitination.
Search PubMed for articles
DESCRIPTION
OF RESEARCH
My lab is interested in mechanisms of malignant transformation
induced by small GTPases of the Ras superfamily. The Rho subfamily
of GTPases regulate diverse cellular processes, including
proliferation, survival, actin remodeling, vesicular trafficking,
and cell polarity. Aberrations in each of these processes
can contribute to the malignant phenotype. My lab focuses
on a novel effector of Rho GTPases, the TRE17 oncogene. TRE17
modulates both actin remodeling as well as vesicular trafficking.
In addition, TRE17 directly modulates cellular ubiquitination.
Current efforts are aimed at understanding how these various
functions of TRE17 lead to transformation.
RECENT
PUBLICATIONS
Masuda-Robens, J.M., Kutney, S., Qi, H., and Chou,
M.M. The TRE17 oncogene encodes a component of a
novel effector pathway for the Rho GTPases Cdc42 and Rac 1
and stimulates actin remodeling. Molecular and Cellular
Biology 23:2151-2161 (2003).
Martinu, L., Masuda-Robens, J.M., Robertson, S.E., Santy,
L.C., Casanova, J. E., Chou, M.M. The TBC
(Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal
trafficking through activation of Arf6. Molecular and
Cellular Biology, 24:9752-9762 (2004).
Shen, C., Ye, Y., Robertson., S.E., Lau, A.W., Mak, D.-O.
D, and Chou, M.M. Calcium/calmodulin regulates
ubiquitination of the ubiquitin-specific protease TRE17/USP6.
Journal of Biological Chemistry, 280: 35967-35973
(2005).
Oliveira, A.M., Chou, M.M., Perez-Atayde,
A.R., and Rosenberg, A.E. Aneurysmal Bone Cyst: A Neoplasm
Driven by Upregulation of the USP6 Oncogene. Journal of
Clinical Oncology 24:1 (2006).
Lau, A.W. and Chou, M.M. Mechanisms of
Arf6 activation by TRE17/USP6: Requirement for binding but
not mono-ubiquitination of TRE17/USP6. Submitted.
Lab
ROTATION
PROJECTS
- Characterize mechanisms of actin remodeling by TRE17
- Characterize mechanisms of endocytic trafficking TRE17
- Examine mechanism by which TRE17 induces secretion of inflammatory cytokines
- Compare cellular functions of PRC17 and USP32, TRE17's closest homologs
- Lab
personnel:
- Alan Lau (Graduate Student)
Ying Ye (Graduate Student)
Lashon Ussin (Graduate Student)
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last updated 10/2007
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