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Brian
Keith
Associate Investigator and Director of Education,
Abramson Family Cancer Research Institute
Adjunct Associate Professor, Department of Cancer Biology
Chair, Cancer Biology Program, CAMB
Cancer Biology Program
Address
453 Biomedical Rsch Bldg (BRB) II/III
421 Curie Boulevard
Philadelphia, PA 19104-6140
Office tel.: 215 746-5533
Lab tel.: 215 746-5526
Fax: 215 746-5511
E-mail: bkeith@mail.med.upenn.edu
Link(s)
Dr.
Celeste Simon's Lab Page
EDUCATION
Brown University: BS (Biology), 1980.
Rockefeller University: PhD (Plant Molecular
Biology), 1987.
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RESEARCH INTERESTS
How cells and tissues adapt to oxygen deprivation (hypoxia)
by modifying gene expression..
Key words:
mouse, development, transcription, hypoxia,
cancer.
Search PubMed for articles
DESCRIPTION OF
RESEARCH
As part of a long-standing collaboration with Dr. Celeste
Simon, I generate mouse models in which genes encoding critical
components of the hypoxic response pathway are mutated. These
tools offer insights into physiological responses to hypoxia
during normal development, as well as in pathological contexts
(ischemia, cancer).
RECENT PUBLICATIONS
Keith, B., and Simon, M. C.
(2007) Hypoxia Inducible Factors, stem cells, and cancer.
Cell. 129: 465-472.
Gruber, M., Hu, C.-J., Johnson, R. D., Brown,
E. J., Keith, B., and Simon, M. C. (2007)
Acute postnatal ablation of Hif-2α results in
anemia. Proc. Natl. Acad. Sci. 104: 2301-2306.
Covello, K.L., Kehler, J., Yu, H., Gordan, J.G.,
Arsham, A.M., Hu, C.-J., Labosky, P.A., Simon, M.C., and Keith,
B. (2006) HIF-2± regulates Oct-4: effects
of hypoxia on stem cell function, embryonic development, and
tumor growth. Genes & Dev. 20: 557-570.
Liu, L., Cash, T.P., Jones, R.G., Keith,
B., Thompson, C.B., and Simon, M.C. (2006) Hypoxia
induced energy stress regulates mRNA translation and cell
growth. Molecular Cell 21: 521-531.
Covello, K.L., Simon, M.C., and Keith,
B. (2005) Targeted replacement of HIF-1α by
a HIF-2α knock-in allele promotes tumor growth. Cancer
Research 65: 2277-2286.
Mansfield, K.D., M.C. Simon, and B.
Keith. (2004). Hypoxic reduction of intracellular
gluathione requires mitochondrial reactive oxygen species
(mtROS). J. Applied Physiol. 97(4):1358-66.
Brunelle, J.K., M.T. Santore, G. R. Budinger,
Y. Tang, T.A. Barrett, W.X. Zong, E. Kandel, B. Keith,
M.C. Simon, C.B. Thompson, N. Hay, and N.S. Chandel. (2003).
c-Myc sensitization to oxygen deprivation induced cell death
is dependent on Bax/Bak but independent of p53 and HIF-1.
J. Biol. Chem. 279:4305-12.
Mack, F., W. K. Rathmell, A. Arsham, J. Gnarra,
B. Keith, and M. C. Simon. (2003) Loss of
pVHL is sufficient to cause HIF dysregulation in primary cells
but does not promote tumor growth. Cancer Cell 3:
75-88.
Hu, C.-J., L.Y. Wang,, L. A. Chodosh, B.
Keith, and M.C. Simon. (2003). Differential Roles
of HIF-1α and HIF-2α in hypoxic gene regulation.
Mol. Cell. Biol. 23:9361-74.
Lab
Rotation Projects
Students intersted in rotation projects should refer to
Dr. Celeste Simon's lab page.
- Lab
personnel:
- Please refer to Dr. Celeste Simon's lab.
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last updated 10/2007
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