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Gary
Koretzky, MD, PhD
Professor, Dept of Pathology and Laboratory Medicine
Investigator and Director, Signal Transduction Program, Abramson
Family Cancer Research Institute
Cancer Biology Program
Address
415 Biomedical Research Bldg II/III (Office)
427 Biomedical Research Bldg II/III (Lab)
421 Curie Blvd
Philadelphia,
PA 19104-6160
Office tel.: 215 746-5522
Lab tel.: 215 746-5541, 5542
Fax: 215 746-5525
E-mail: koretzky@mail.med.upenn.edu
Education
Cornell University: AB (Biology), 1978.
University of Pennsylvania: MA (Honorary), 1999.
University of Pennsylvania: PhD (Immunology), 1984.
University of Pennsylvania: MD (Medicine), 1984.
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Research
Interests
- Role of adaptor proteins in immune cell develoment and
function
- Signals leading to T cell activation and termination
of T cell responses
- In vitro and in vivo function of mast cells and neutrophils
- Signals leading to specification of blood vessels and
lymphatics
Key
words: signal transduction, adaptor
proteins, SLP-76, DGK-zeta, T-cell activation, TCR signaling.
Search PubMed for articles
Description
of Research
Our laboratory studies the regulation of signaling events
which lead to hematopoietic cell development and function.
We make extensive use of genetically altered mice for these
studies. To date, we have identified three novel adapter proteins
and have made mice deficient in each of these molecules. We
have also investigated the role of enzymes by targeted gene
deletion. Collectively these studies have provided new insights
into how these proteins serve as regulators of multiple lineages
in the hematopoietic system.
Recent
Publications
Koretzky, G.A. and Kahn, M.L. Regulation of blood and lymphtic
vascular separation by signaling proteins SLP-76 and Syk.
Science, 299:247-251,2003.
Newbrough, S.A., Mocsai, A., Clemens, R.A., Wu, J.N., Silverman,
M.A., Singer, A.L., Lowell, C.A. and Koretzky, G.A. SLP-76
regulates Fc? receptor and integrin signaling in neutrophils.
Immunity, 19:541-552, 2003.
Zhong, X-P., Hainey, E.A., Olenchock, B.A., Jordan, M.S.,
Maltzman, J.S., Nihols, K.E., Shen, H. and Koretzky, G.A.
Enhanced T cell responses due to diacylglycerol kinase ? deficiency.
Nat. Immunol., 4:882-890, 2003.
Clemens, R.A., Chung, E.Y., Gheith, S., Singer, A.L., Koretzky,
G.A., Peterson, E.J. PRAM-1 is required for optimal integrin-dependent
neutrophil function. Mol. Cell. Biol. 24:10923-32,
2004.
Nichols, K.E., Hom, J., Gong, S.Y., Ganguly, A., Ma, C.S.,
Cannons, J.L., Tangye, S.G., Schwartzberg, P.L., Koretzky,
G.A., Stein, P.L. Regulation of NKT cell development by SAP,
the protein defective in XLP. Nat. Med. 11:340-45,
2005.
Lab
Rotation
Projects
Studies of the molecular and biochemical role of adapter
proteins in hematopoietic cell development and growth.
- Lab
personnel:
- Farhad Abtahian (Graduate Student)
Natalie Bezman (Graduate Student)
Regina Clemens (Graduate Student)
Marisa Juntilla (Graduate Student)
Ben Olenchock (Graduate Student)
Michael Silverman (Graduate Student)
Martha Jordan, PhD (Instructor)
Taku Kambayashi, MD/PhD (Postdoctoral Fellow)
Jonathan Maltzman, MD/PhD (Postdoctoral Fellow)
Gael Menasche, PhD (Postdoctoral Fellow)
Kim Nichols, MD (Visiting Scholar)
Selene Nunez, PhD (Postdoctoral Fellow)
Jessica Austin (Research Specialist)
Emily Chen (Research Specialist)
Lisa Kovoor (Research Specialist)
last updated 7/2005
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