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Carlo
Maley, Ph.D.
Assistant Professor, Dept. of Molecular and Cellular Oncogenesis, The Wistar Institute
Cancer Biology Program
Address
The
Wistar Institute, Room 352B
3601 Spruce St.
Philadelphia, PA 19104
Office tel.: 215 495-6838
Lab tel.: 215 495-6839
Fax: 215 495-6829
E-mail: cmaley@wistar.org
Education
Oberlin
College: BA (Computer Science and Psychology), 1991.
University of Oxford: M.Sc. (Zoology), 1993.
MIT: Ph.D. (Computer Science;Computational Biology), 1998.
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Research
Interests
- Evolution in cancer, neoplastic progression and therapeutic resistance.
Key words: evolution, meoplastic progression, therapeutic resistance, cancer,
Barrett's esophagus, ecology, computational modeling, cancer stem cells, population genetics, diversity.
Description
of Research
The
Maley laboratory is applying evolutionary and ecological theory
to neoplastic progression and therapeutic resistance in order
to modulate the evolution of neoplastic cells and thereby
prevent cancer and its relapse. We take three, mutually reinforcing
approaches to these problems: computational simulations to
explore hypotheses, data mining of (application of evolutionary
theory to) genetic data from neoplasms, and evolutionary experiments
in tissue culture.
Current projects in the lab include:
Measuring
genetic diversity in neoplasms and testing if it predicts
both progression and therapeutic resistance.
Applying
phylogenetic methods to measure the parameters of evolution
in neoplasms.
Developing
in vitro competition assays to find cancer prevention drugs.
Developing
experimental models of Barrett’s Esophagus.
Harnessing
clonal evolution to prevent cancer.
Computational
modeling of the mechanisms of clonal expansion.
Computational
modeling of neoplastic progression.
Selected
Publications
Pepper, J., Sprouffske, K., Maley, C.C.: Cell Differentiation Patterns Suppress Somatic Evolution. PLoS Computational Biology, 3:e250, 2007. Highlighted in Nature Online
Galipeau, P.C., Li X, Blount, P.L., Maley, C.C.
Sanchez, C.A. Odze, R.D., Ayub, K. Rabinovitch, P.S., Vaughan,
T.V. Reid, B.J.(2007) NSAIDs modulate CDKN2A, TP53, and DNA
content risk for progression to esophageal adenocarcinoma.
PLoS Medicine. 4(2):e67.
Merlo, L., Pepper, J., Reid, B.J., Maley, C.C.(2006)
Cancer as an evolutionary and ecological process. Nature
Reviews Cancer, 6:924–35.
Maley, C.C., Galipeau, P.C., Finley, J.C., Wongsurawat,
V.J., Li, X., Sanchez, C.A., Paulson, T.G., Blount, P.L.,
Risques, R., Rabinovitch, P.S. and Reid, B.J. (2006) Genetic
clonal diversity predicts progression to esophageal adenocarcinoma.
Nature Genetics, 38:468–473.
Maley, C. C., Reid, B. J., Forrest, S. (2004)
Cancer prevention strategies that address the evolution of
neoplastic cells: Simulating benign cell boosters and selection
for chemosensitivity. Cancer Epidemiology, Biomarkers
and Prevention, 13:1375-84.
Search PubMed for more articles
Lab
Rotation Projects
- Measuring genetic diversity within neoplasms
- Somatic evolution in AML stem and non-stem cells
- 3D organotypic reconstruct tissue culture models of Barrett's esophagus
- The effects of NSAIDs and vitamin C on neoplastic progression
- Modulating clonal competition in neoplastic progression
- Tumor suppressor genes in humpback whales
- Slowing somatic evolution
- The evolution of metastasis
- The evolution of anti-angiogenic factors
- Lab personnel:
Dr. Lauren Merlo - Postdoctoral Researcher
Rumen Kostadinov - Graduate Student
Kathleen Sprouffske - Graduate Student
Kristin Gardiner - Research Assistant
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