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Steven L. Reiner, M.D.
Professor, Dept of Medicine, Division of Infectious Diseases and Abramson Family Cancer Research Institute;
Chair, Immunology Graduate Group
Cancer Biology Program
Address
Biomedical Rsch Bldg (BRB) II/III, Room 414
421 Curie Boulevard
Philadelphia, PA 19104-6160
Office tel.: 215 746-5536
Lab tel.: 215 746-5543
Fax: 215 746-5525
E-mail: sreiner@mail.med.upenn.edu
Link(s)
Dr.
Reiner's Abramson page
Dr.
Reiner's Immunology page
Dr.
Reiner's Parasitology page
Education
Haverford College: BA (Philosophy), 1982.
Duke University: MD (Medicine), 1985.
UCSF: Postdoctoral Research (Biochemistry), 1990-1994.
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Research
Interests
- asymmetric cell division; stem cell self-renewal; epigenetic and transcription factor-mediated control of gene expression; host response to infection and cancer; effector and memory T lymphocyte differentiation;
Key
words: asymmetric cell division, stem cells, transcription, lymphocyte.
Description of Research
Diversifying cell fate in essential and unwanted cells
Using lymphocytes as a model system, we recently proposed that asymmetric cell division may be a way for many mobile, non-polarized cells to generate cell fate diversity among their progeny. We are using static and time-lapsed imaging, genetic, and biochemical methods to better understand the nature and extent of asymmetric cell division in multi-celled beings. It is predicted that this will have immediate relevance for the way in which blood stem cells and metastatic cancer stem cells can generate diverse progeny despite their lack of obvious polarity. Studies of lymphocyte differentiation during the immune response should continue to become an increasingly useful model for inquiry into the fundamental problem of regulated gene expression in dividing, differentiating, and highly mobile cells.
Selected Publications
Intlekofer, A.M., A. Banerjee, N. Takemoto,
S.M. Gordon, C.S. DeJong, H. Shin, C.A. Hunter, E.J. Wherry,
T. Lindsten, and S.L. Reiner. 2008. Anomalous type 17 response
to viral infection by CD8+ T cells lacking T-bet and eomesodermin.
Science 321:408-411.
Reiner, S.L., F. Sallusto, and A. Lanzavecchia.
2007. Division of labor with a workforce of one: challenges
in specifying effector and memory T cell fate. Science
317:622-625.
Reiner, S.L. 2007. Development in motion: helper
T cells at work. Cell 129:33-36.
Intlekofer, A.M., N. Takemoto, C. Kao, A. Banerjee,
F. Schambach, J.K. Northrop, H. Shen, E.J. Wherry, and S.L.
Reiner. 2007. Requirement for T-bet in the aberrant differentiation
of unhelped memory CD8+ T cells. J Exp Med 204:2015-2021.
Chang, J.T., V.R. Palanivel, I. Kinjyo, F. Schambach,
A.M. Intlekofer, A. Banerjee, S.A. Longworth, K.E. Vinup,
P. Mrass, J. Oliaro, N. Killeen, J.S. Orange, S.M. Russell,
W. Weninger, and S.L. Reiner. 2007. Asymmetric T lymphocyte
division in the initiation of adaptive immune responses. Science
315:1687-1691.
Search PubMed for more articles
Lab
Rotation
Projects
- Study the mechanisms involved mediating asymmetric division of T cells, blood stem cells and cancer stem cells.
Characterize the mechanisms of action of novel transcriptional regulators of immune cell differentiation.
- Lab
personnel:
- Arnob Banerjee - Postdoctoral fellow
John Chang - Postdoctoral fellow
Caitlin DeJong - Research specialist
Jiyeon Kim - Rotation student
Courtney McClurkin - Research specialist
Michael Paley - Rotation student
last updated 9/2008
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