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Steven L. Reiner, M.D.
Professor, Dept of Medicine, Division of Infectious Diseases and Abramson Family Cancer Research Institute; Chair, Immunology Graduate Group
Cancer Biology Program
Address
Biomedical Rsch Bldg (BRB) II/III, Room 414
421 Curie Boulevard
Philadelphia, PA 19104-6160
Office tel.: 215 746-5536
Lab tel.: 215 746-5543
Fax: 215 746-5525
E-mail: sreiner@mail.med.upenn.edu
Link(s)
Dr.
Reiner's Abramson page
Dr.
Reiner's Immunology page
Dr.
Reiner's Parasitology page
EDUCATION
Haverford College: BA (Philosophy), 1982.
Duke University: MD (Medicine), 1985.
UCSF: Postdoctoral Research (Biochemistry), 1990-1994.
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Research
Interests
- Transcriptional control of lymphocyte differentiation.
Gene silencing, chromatin structure and DNA methylation.
Key
words: chromatin, epigenetics,
transcription, lymphocyte.

Search PubMed for articles
Description of Research
T cell differentiation and the problem
of cellular inheritance
The Reiner laboratory studies how lymphocytes
make decisions. A combination of extrinsic signals triggered
by pathogens can lead to divergent immune cell fates, each
of which plays a critical role in defending us against the
diversity of microbial opponents. The clonal expansion of
a naive T cell during an immune response provides a model
to study the sequential plasticity/stability of cellular differentiation.
The ability to manipulate T cell gene expression in vitro
and in vivo, together with an ability to perform phenotypic
and biochemical studies of chromatin within specific cell
divisions should allow construction of a detailed cellular
and sub-cellular fate map of an important developmental program
in mammals, the immune response. Study of T cell differentiation
should continue to become an increasingly useful model for
inquiry into the fundamental problem of regulated gene expression
in dividing and differentiating cells. Such studies should
also illuminate a novel set of pathways that can be targeted
for enhancing or diverting the immune response.
Recent Publicantions
Pearce, E.L., Mullen, A.C., Martins, G.A.,
Krawczyk, C.K., Hutchins, A. S., Zediak, V.P., Banica, M.,
DiCioccio, C.B., Gross, D.A, Mao, C., Shen, H., Cereb, N.,
Yang, S.Y., Lindsten, T., Rossant, J, Hunter, C.A., and Reiner,
S.L. Control of effector CD8+ T cell function by
the transcription factor Eomesodermin. Science, 302:1041-1043,
2003.
Tato, C.M., Martins, G.A., High, F.A., DiCioccio,
C.B., Reiner, S.L. and Hunter C.A. Cutting
Edge: Innate production of IFN-gamma by NK cells is independent
of epigenetic modification of the IFN-gamma promoter. Journal
of Immunology 173:1514-1517, 2004.
Lieberman, L.A., Banica, M., Reiner,
S.L. and Hunter C.A. STAT1 plays a critical role
in the regulation of antimicrobial effector mechanisms, but
not in the development of Th1-type responses during toxoplasmosis.
Journal of Immunology 172:457-463, 2004.
Anfossi, N., Robbins, S.H., Ugolini, S., Georgel,
P., Hoebe, K., Bouneaud, C., Ronet, C., Kaser, A., DiCioccio,
c.B., Tomasello, E., Blumberg, R.S., Beutler, B., Reiner,
S.L., Alexopoulou, L., Lantz, O., Raulet, D.H., Brossay,
L. and Vivier, E. 2004. Expansion and function of CD8+ T cells
expressing Ly49 inhibitory receptors specific for MHC class
I molecules. J Immunol 173:3773-3782.
Hewitt, S.L., High, F.A., Reiner, S.L.,
Fisher, A.G., and Merkenschlager, M. 2004. Nuclear repositioning
marks the selective exclusion of lineage-inappropriate transcription
factor loci during T helper cell differentiation. European
Journal of Immunology 34:3604-3613.
Lab
Rotation
Projects
Characterize the mechanisms of action of novel transcriptional
regulators of immune cell differentiation.
- Lab
personnel:
- Arnob Banerjee - Postdoctoral fellow
John Chang - Postdoctoral fellow
Christopher Gasink – Postdoctoral fellow
Andrew Intlekofer – Graduate student
Ichiko Kinjo - Postdoctoral fellow
Sarah Longworth - Research specialist
John Northrup - Research specialist
Felix Schambach - Postdoctoral fellow
Jennifer Stundon – Research specialist
Naofumi Takemoto - Postdoctoral fellow
last updated 8/2005
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