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Mark
L. Tykocinski, M.D.
Simon Flexner Professor and Chair, Dept of Pathology &
Laboratory Medicine
Cancer Biology Program
Address
410 Stellar Chance / 6100 (Lab)
422 Curie Blvd
Philadelphia, PA 19104
6.036 Gates Pavilion (Office)
3400 Spruce Street
Philadelphia, PA 19104-4283
Office tel.: 215 662-6880
Lab tel.: 215 573-6000
Fax: 215 662-4063
E-mail: mlt4@mail.med.upenn.edu
Link(s)
Dr.
Tykocinski's Faculty Chair Page
Dr.
Tykocinski's Immunology Faculty Page
EDUCATION
Yale University: BA Magna Cum Laude (Biology), 1974.
New York University: MD (Medicine), 1978.
Columbia-Presbyterian Medical Center: Residency (Internal
Medicine), 1978-1979.
New York University: Residency (Anatomic Pathology), 1979-1981.
National Institutes of Health: Medical Staff Fellow (Immunogenetics),
1981-1983.
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Research Interests
Search PubMed for articles
Recent Publications
Dranitzki Elhalel, M., Huang, J.-H., Schmidt, W., Rachmilewitz,
J., and Tykocinski, M.L. CTLA-4-FasL induces alloantigen-specific
hyporesponsiveness. Journal of Immunology, 170:5842-5850,
2003.
Chen, A., Zheng, G., and Tykocinski, M.L. Quantitative interplay
between activating and pro-apoptotic signals dictates T cell
responses. Cellular Immunology, 221:128-137, 2003.
Rachmilewitz, J. Borovsky, Z., Riely, G.J., Miller, R., and
Tykocinski, M.L. Negative regulation of T cell activation
by placental protein 14 is mediated by the tyrosine phosphatase
receptor CD45. Journal of Biological Chemistry, 278:14059-14065,
2003.
Tykocinski ML, Chen A, Huang JH, Weber MC, Zheng G. New designs
for cancer vaccine and artificial veto cells: an emerging
palette of protein paints. Immunol Res. 2003;27(2-3):565-74.
Zheng, G., Chen, A., Sterner, R., Zhang, P., Pan, T., Kiyatkin,
N., and Tykocinski, M.L. Induction of anti-tumor immunity
via intratumoral tetra-costimulator protein transfer. Cancer
Res. 10:57-61, 2001.
Lab
Rotation Projects
- Design and evaluation of trans signal converter proteins
for treatment of autoimmunity
- T cell autocostiumlation and engineering of therapeutic
T cells
- Placental protein 14 and T cell immunosupression.
- Lab
personnel:
- Nadya Kiyatkina - Research Specialist B
Marjaneh Razmara, PhD - Postdoctoral Fellow
Masahide Tone, PhD - Research Associate Professor
Yukiko Tone, PhD - Postdoctoral Fellow
Matthew Weber, PhD - Senior Research Investigator
Hong-Wu Xu, PhD - Senior Research Investigator
Srikanth Yellayi, PhD - Postdoctoral Fellow
Lama Youssef, PhD - Postdoctoral Fellow
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last updated 8/2004
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