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Michael
S. Parmacek, M.D.
Herbert
C. Rorer Professor of Medical Sciences, Chief Division of
Cardiovascular Medicine
Developmental
Biology Program
Address
907 Biomedical Rsch Bldg II/III (Office)
932 Biomedical Rsch Bldg II/III (Lab)
421 Curie Boulevard
Philadelphia, PA 19104-6140
Office tel.: 215 662-3140
Lab tel.: 215 898-9011
Fax: 215 349-8017
E-mail: michael.parmacek@uphs.upenn.edu
Education
Tufts University, B.S. (Biology-Psychology), 1977
Northwestern University, M.D., 1981
Howard Hughes Medical Institute, University of Michigan, Postdoctoral
Fellowship (Molecular Cardiology) ,1987-1990
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Research
Interests
- Transcriptional programs that regulate cardiovascular
development
Key
words: smooth muscle cell, cardiac
myocyte, GATA, myocardin, transcription, notch .
Search PubMed for articles
Description
of Research
The Parmacek laboratory examines the molecular
mechanisms underlying cardiovascular development with particular
focus on elucidating the transcriptional programs controlling
specification and differentiation of the muscle cell lineages.
These studies are fundamentally important at a basic level
and have provided important insights into the pathogenesis
of congenital heart disease, cardiac hypertrophy and vascular
proliferative syndromes including atherosclerosis. In the
Parmacek laboratory, which is located in the Molecular Cardiology
Center, gene targeting in embryonic stem (ES) cells and mice
is routinely utilized to examine the molecular basis of cardiac
myocyte and vascular smooth muscle cell development and differentiation.
Members of the Parmacek laboratory first cloned and characterized
the GATA-4/5/6 subfamily of zinc finger transcription factors
that have been shown to play critical roles in the developing
heart and vascular system. Mutations in GATA-4 are associated
with common forms of congenital heart disease observed in
humans. Parmacek also defined the serum response factor (SRF)-dependent
transcriptional program that regulates vascular smooth muscle
cell differentiation and modulation of smooth muscle cell
phenotype which occurs in atherosclerosis. In recent years,
the Parmacek laboratory has focused on examining the function(s)
of the SAP domain transcription factor, myocardin, and two
myocardin-related transcription factors (MRTFs)-A and –B
in the cardiovascular system. Graduate students and postdoctoral
fellows interested in obtaining training in molecular cardiology,
stem cell biology, transgenic and genetically engineered models
of cardiovascular disease are encouraged to apply for positions.
Recent
Publications
Camoretti-Mercado B, Fernandes DJ, Dewundara
S, Churchill J, Ma L, Kogut PC, McConville JF, Parmacek MS,
Solway J: Inhibition of TGF ß1-Enhanced SRF-Dependent
Transcriptional Activity by Smad7. J Biol Chem. Jul21;281(29):20383-92,
2006.
Proweller A, Tu L, Lepore J, Cheng L, Lu MM,
Seykora J, Millar S, Pear W, Parmacek MS: Impaired notch signaling
promotes De novo squamous cell carcinoma formation. Cancer
Res. Aug 1;66(15):7438-44, 2006.
Hannenhalli S, Putt M, Gilmore J, Wang J, Parmacek
MS, Epstein J, Morrisey E, Margulies K, Cappola T: Transcriptional
genomics associates FOX transcription factors with human heart
failure. Circulation Sep 19;114(12):1269-76, 2006.
Schaffer RG, Greene S, Arshi A, Supple G, Bantly
A, Moore JS, Parmacek MS, Mohler ER: Effect of acute exercise
on endothelial progenitor cells in patients with peripheral
arterial disease Vasc Med Nov;11(4):219-226, 2006.
High FA, Zhang M, Proweller A, Tu L, Parmacek
MS, Pear WS, Epstein JA: An essential role for Notch in neural
crest during cardiovascular development and smooth muscle
differentiation. J Clin Invest Feb 1;117(2):353-363,
2007.
Lab
Rotation
Projects
- Characterization of the function of MRTF-B
in the heart and vasculature
- Examine the molecular basis of Myocardin
function in the heart and in vascular smooth muscle cells
- Characterization of mice harboring a conditional
mutation in the lineage-restricted transcription factors
GATA-6
- Examine the role of Notch signaling and
Notch-regulated genes during angiogenesis and in the vasculature
- Lab
personnel:
- Aaron Proweller MD, PhD - Postdoctoral Research
Fellow, Instructor, Dept. of Medicine
Jian Li, MD - Senior Research Scientist
John Huang MD, PhD - Postdoctoral Research Fellow
Mary Chen - Senior Research Technician
Xiaohong Zhu - Senior Research Technician
Xiaoqing Zhu - Visiting Scholar
last updated 8/2007
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