Genetics and Gene Regulation Program

Address

813A Stellar-Chance
422 Curie Blvd
Philadelphia PA 19104-6100

Office tel.: 215 573 -7473
Lab tel.: 215 898-0711
E-mail: hnelson@mail.med.upenn.edu

Education

Yale University, B.S. (Molecular Biochemistry and Biophysics) 1979

MIT, Ph.D. (Biology, Biochemistry)1985

MRC Laboratory of Molecular Biology, postdoc (Structural Biology)1985-1989

Selected Publications

Conlin, L.C. and Nelson, H.C.M. (2007) Trehalose affects the transcriptional activity of yeast heat shock transcription factor. Mol. Cell. Biol. 27:1505-1515.

Zhao, X., Shi, H., Sevilimedu, A., Liachko, N., Nelson, H.C.M., and Lis, J.T. (2006) An RNA aptamer that interferes with the DNA binding of the HSF transcription activator. NAR 34:3755-3761.

Eastmond, D.L. and Nelson, H.C.M. (2006) Genome-wide analysis reveals new roles for the activation domains of the Saccharomyces cerevisiae heat shock transcription factor (Hsf1) during the transient heat shock response. JBC 281:32909-32921.

Ferguson, S.B., Anderson, E.A., Harshaw, R.B., Thate, T., Craig, N.L., and Nelson, H.C.M. (2005) Protein kinase A regulates constitutive expression of small heat shock genes in an Msn2p/4p-independent and Hsf1p-dependent manner in Saccharomyces cerevisiae. Genetics 169:1203-1214.

Bulman, A.L. and Nelson, H.C.M. (2005) Role of trehalose and heat in the structure of the C-terminal activation domain of the heat shock transcription factor. Proteins 58:826-835.

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