Genetics and Gene Regulation Program

Address

315A Abramson Research Center
The Children’s Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104-4318

Office tel.: 215 590-3880
Lab tel.: 215 590-3878
Fax: 215 590-4834
E-mail: jeruss@mail.med.upenn.edu

EDUCATION

Harvard University, B.A. (mcl) (Chemistry) 1980

Stanford University School of Medicine, M.D., 1984

Hospital of the University of Pennsylvania (Houseofficer training (Internal Medicine) / Fellowship (Hematology-Oncology) 1984-1991

RESEARCH INTERESTS

• Control and function of human embryonic globin genes.

Key words: Globin, embryonic, sickle cell anemia, thalassemia, mRNA, prothrombin.

Search PubMed for articles

RECENT PUBLICATIONS

Kihm, A.J, Kong, Y., Hong, W., Russell, J.E., Rouda, S., Adachi, K., Simon, S.C., Blobel, G.A., and Weiss, M.J. (2002) An abundant erythroid protein that stabilizes free alpha-haemoglobin. Nature 417:758-763.

He, Z., and Russell, J.E. (2002) A high-throughput microplate method for assessing aggregation of deoxygenated Hb S in vitro. Anal. Biochem. 306:349-352.

Pollak, E.S., Lam, H.-S., and Russell, J.E. (2002) The G20210A mutation does not affect the stability of prothrombin mRNA in vivo. Blood 100:359-362.

He, Z., and Russell, J.E. (2002) A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease. Proc. Natl. Acad. Sci. U.S.A. 99:10635-40.

Bilenoglu, O., Basak, A.N., and Russell, J.E. (2002) A 3'UTR mutation affects beta-globin gene expression without altering the stability of its fully-processed mRNA. Br. J. Haemat. 119:1106-14.

Lab

ROTATION PROJECTS

Please see Dr. Russell.

Lab personnel:

He, Zhenning
Xu, Xiang-Sheng
Liu, Xingge
Jiang, Yong
Procopio, William