Jean Boyer
Associate Research Professor, Depts of Pathology and Laboratory Medicine

Gene Therapy & Vaccines Program

Address

505 Stellar Chance Laboratories
422 Curie Boulevard
Philadelphia, PA 19104

Office tel.: 215 662-2382
Lab tel.: 215 662-2382
Fax: 215 573-9436
E-mail: boyerj@mail.med.upenn.edu


Education

Rutgers University: BS (Biochemical Engineering), 1984.

Rutgers University: PhD (Biochemical Engineering), 1990.

Research Interests

• Induction of cellular immune response to vaccines, comparative analysis of cellular immunity following infection or vaccination

Key words: HIV, Vaccine, Cellular Immunity

Search PubMed for articles

Description of Research

he research on-going within the laboratory involves the study of the cellular immune response induced following vaccination. Research interests include investigating the mechanisms by which an induced cellular immune response can induce protection from a challenge with SIV in the Rhesus macaque model. This model has direct implications with regard to the development of an HIV-1 vaccine. Th2 polarized immune responses impact a vaccine induced immune response. The initial work we have undertaken is in the area of chronic parasitic infection and vaccines targeted to HIV-1. This compliments the need for developing an HIV-1 vaccine that will ultimately be distributed internationally.

Recent Publications

Robinson TM, Sidhu MK, Pavlakis GN, Felber BK, Silvera P, Lewis MG, Eldridge J, Weiner DB and Boyer JD. Macaques Immunized with SIVgag/pol-HIVenv Vaccine and IL-12 have Increased Cellular Immune Responses when Compared to Vaccine Alone. Journal of Primatology, 2007.

Boyer JD, Robinson TM, Maciag PC, Peng X, Johnson RS, Pavlakis G, Lewis MG, Shen A, Siliciano R, Brown CR, Weiner DB, Paterson Y. DNA prime Listeria boost induces a cellular immune response to SIV antigens in the rhesus macaque model that is capable of limited suppression of SIV239 viral replication. Virology. 2005 Mar 1;333(1):88-101.

Robinson TM, Nelson R, Artis D, Scott P, Boyer JD. Experimental Leishmania major infection suppresses HIV-1 DNA vaccine induced cellular immune response.
Cells Tissues Organs. 2004;177(3):185-8.

Lab

Rotation Projects

Cellular Immunity in SIV vaccinated Rhesus Macaques, Impact of Parasitic Infection on an Induced Cellular Immune Response Following Vaccination.

Lab personnel:

Jiangmei Yin, Post doctoral Fellow

 

Anlan Dai, Research Specialist
Daniel Schullery, Research Specialist

Mina Naji, Research Specialist
Rita Tamburrino, Technician