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Hildegund
C.J. Ertl, M.D.
Professor, The Wistar
Institute
Gene
Therapy and Vaccines Program
Address
283 The Wistar Institute
3601 Spruce Street
Philadelphia, PA 19104-4268
Office tel.: 215 898-3863
Lab tel.: 215 898-3855
Fax: 215 573-3953
E-mail: ertl@wistar.upenn.edu
Link(s)
The Laboratory of Hildegund C.J. Ertl,
MD
Education
Medical Microbiology Institute, Univ. of Goettingen, Goettingen, Germany: (Microbiology),
1974.
Medical School,
Georg August Univ., Goettingen, Germany: MD, 1977.
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Research
Interests
The laboratory focuses on pre-clinical development of vaccines to infectious diseases and cancer emphasizing basic immunological mechanisms that influence vaccine efficacy.
Key words: HIV Vaccine, HPV vaccines,
Rabies Virus vaccines, Influenza Virus.
Description
of Research
The laboratory develops and explores vaccines based on E1-deleted adenoviral recombinants or adeno-associated viral recombinants to rabies virus, human papillomavirus (HPV) type 16, human immunodeficiency virus (HIV)-1 and influenza A virus.
Selected
Publications
Tatsis N, Fitzgerald JC, Reyes-Sandoval A, Harris-McCoy KC, Hensley SE, Zhou D, Lin SW, Bian A, Xiang ZQ, Iparraguirre A, Lopez-Camacho C, Wherry EJ, Ertl HC. Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines. Blood. 2007.
McCoy K, Tatsis N, Korioth-Schmitz B, Lasaro MO, Hensley SE, Lin SW, Li Y, Giles-Davis W, Cun A, Zhou D, Xiang Z, Letvin NL, Ertl HC. Effect of preexisting immunity to adenovirus human serotype 5 antigens on the immune responses of nonhuman primates to vaccine regimens based on human- or chimpanzee-derived adenovirus vectors.
J Virol. 2007 Jun;81(12):6594-604.
Mingozzi F, Maus MV, Hui DJ, Sabatino DE, Murphy SL, Rasko JE, Ragni MV, Manno CS, Sommer J, Jiang H, Pierce GF, Ertl HC, High KA. CD8(+) T-cell responses to adeno-associated virus capsid in humans. Nat Med. 2007 Apr;13(4):419-22.
Li H, Murphy SL, Giles-Davis W, Edmonson S, Xiang Z, Li Y, Lasaro MO, High KA, Ertl HC. Pre-existing AAV capsid-specific CD8+ T cells are unable to eliminate AAV-transduced hepatocytes. Mol Ther. 2007 Apr;15(4):792-800.
Hensley SE, Cun AS, Giles-Davis W, Li Y, Xiang Z, Lasaro MO, Williams BR, Silverman RH, Ertl HC. Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector. Mol Ther. 2007 Feb;15(2):393-403.
Search PubMed for more articles
Lab
Rotation
Projects
- Characterize the T cell response to a transgene delivered by an adeno-associated virus (AAV) vector.
- Characterize T cells that migrate upon vaccination to the genital tract
- Genital T cell responses
- Interactions between AAV vectors and cells of the innate immune system
- Development of adjuvants based on molecules that block immuno-inhibitory pathways
- Characterize T or B cell responses of aged mice to vaccination with an influenza A virus vaccine
- Lab
personnel
Zhiquan Xiang, MD, Senior Staff Scientist
Xiangyang Zhou, MD PhD, Senior Staff Scientist
Marcio Lasaro, PhD, Staff Scientist
Dongming Zhou, PhD, Staff Scientist
Hua Li, PhD, Associate Staff Scientist
Juliana Small, Predoctoral Trainee
Te-Lang Wu, Predoctoral Trainee
Wynetta Giles-Davis, Research Technician
Yan Li, Research Technician
Ang Bian, Research Technician
Lauren DiMenna, Research Technician
Brian Latimer, Research Technician
Larissa Haut, Visiting Scientist
Katrin Toepfer, Visiting Scientist
Christina Cole, Lab Coordinator
Colin Barth, Lab Coordinator
Emily Liu, Project Manager
Abdelaziz Bior, Collaborator
last updated
7/2008
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