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Fevzi
Daldal
Professor,
Dept of Biology
Microbiology,
Virology and Parasitology Program
Address
103B Carolyn Lynch Labs
433 S. University Ave.
Philadelphia, PA 19104
Office tel.: 215 898-4394
Lab tel.: 215 898-5385
Fax: 215 898-8780
E-mail: fdaldal@sas.upenn.edu
Link
Dr. Daldal's
Biology Dept Page
Dr.
Daldal's BMB Grad Group Page
Education
Lyon Engineering School, Lyon, France: BS (Biochemistry),
1974.
University of Pasteur Strasbourg, France: PhD (Microbial Genetics),
1977.
Harvad Medical School: Postdoctoral Research (Molecular genetics),
1978-82.
Cold Spring Harbor: Staff Scientist (1983-1988).
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Research
Interests
- Structure, function, regulation and biogenesis
of bacterial cytochromes.
Key words: cytochrome and cytochrome
complexes, microbial energy transduction, photosynthetic bacteria,
photosynthesis and respiration, membrane protein biogenesis.
Search PubMed for articles
Description
of Research
Our work is focused on the structure, function,
assembly, biogenesis and
regulation in response to environmental signals (light and
oxygen) of
multi-subunit, prosthetic groups bearing membrane proteins
involved in
cellular energy transduction (photosynthesis and respiration)
pathways.
These proteins are vital for important cellular functions
that extend
from ATP synthesis to secretion, solute transport, motility
and
thermogenesis. Their dysfunction severely compromises cellular
energy
production, and leads to neurological and muscular diseases
in humans,
or to lower crop yields in plants. We employ molecular genetic
and
genomic/proteomic approaches in combination with molecular
biological,
biochemical, biophysical and structural techniques, and we
work with the
purple non-sulfur facultative photosynthetic bacterium Rhodobacter
capsulatus as a model organism instead of eukaryotic organelles
that are
more refractory to multidisciplinary analyses. Ongoing research
involves
the cytochrome bc1 complex, the cytochrome cbb3 oxidase and
their
physiological electron carriers.
Recent
Publications
Cooley, J. W., T. Ohnishi and F. Daldal. 2005.
Binding dynamics at the
quinone reduction (Qi) site influence the equilibrium interactions
of
the iron sulfur protein and hydroquinone oxidation (Qo) site
of the
cytochrome bc1 complex. Biochemistry, 44: 10520-10532.
Kulajta, C., J. O. Thumfart, S. Haid, F. Daldal
and Koch, H-G. (2006)
Multi-step assembly pathway of the cbb3-type cytochrome c
oxidase
complex. J. Mol. Biol. 355: 989-1004.
Turkarslan, S., Sanders, C. and F. Daldal. 2006.
Extracytoplasmic
prosthetic group ligation to apoproteins: maturation of c-type
cytochromes. Molec. Micro., 60: 537-541.
Lee. D-W., Y. Ozturk, A. Mamedova, A., Osyczka, J. W. Cooley and F.
Daldal. 2006. A functional hybrid between the cytochrome bc1 complex and
its physiological membrane anchored electron acceptor cytochrome cy in
Rhodobacter capsulatus. Biochim. Biophys. Acta, 1757: 346-352.
Aygun, S., S. Mandaci, H-G. Koch, H. Goldfine and F. Daldal. 2006.
Ornithine lipids are required for membrane cytochrome complexes. Molec.
Microbiol., 61: 418-435.
Onder, O., Yoon, H., B. Naumann, M. Hippler, A. Dancis and F. Daldal.
2006. Modifications of the lipoamide-containing mitochondrial
subproteome in a yeast mutant defective in cysteine desulfurase.
Molecular & Cellular Proteomics, 5: 1426-1436.
Lab
Rotation
Projects for 2006-2007
Call or send email for an appointment to discuss
together.
- Lab
personnel:
- Carsten Sanders, Postdoctoral fellow
Jason Cooley, Postdoctoral fellow
Ozlem Onder, Postdoctoral Fellow
Dong-Woo Lee, Postdoctoral fellow
Marc Schmmidt, Postdoctoral fellow
Jean Emmanuel Sarry, postdoctoral fellow
Serdar Turkarslan, PhD student
Semra Aygun sunar, visiting student
last updated 6/2006
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