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Glenn
Rall
Associate
Professor, Division of Basic Science
Microbiology,
Virology and Parasitology Program
Address
The Fox Chase Cancer Center
333 Cottman Ave
Philadelphia PA 19111
Office tel.: 215-728-3617
Lab tel.: 215-728-3677
Fax: 215-728-2412
E-mail: glenn.rall@fccc.edu
Link(s)
Dr. Rall's
FCCC web page
Education
Lafayette College: BS with Honors (Biology), 1985.
Vanderbilt University: PhD (Microbiology and Immunology),
1990.
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Research
Interests
- Viral pathogenesis, neurovirology, neuroimmunology.
Key words: measles, neuron, CNS, immunology.
Search PubMed for articles
Description
of Research
The overall theme of our laboratory is to understand
basic paradigms of viral infection of the CNS and the consequences
of such an infection on the host. The major questions include:
- how do viruses gain access to the CNS from
the periphery;
- how do neurotropic viruses replicate within
the brain;
- what role, if any, does the host immune
response play in the control of such infections;
- what host and viral factors (e.g., viral
dose, host age, host immunocompetence) dictate the overall
pathogenesis of such an infection?
To address these issues, we use a combination
of transgenic mouse and primary cell culture models to study
the virology and immunobiology of measles virus infection
and lymphocytic choriomeningitis virus (LCMV) infection of
neurons. By understanding the factors which contribute to
CNS diseases caused by viruses, we will be in a more informed
position to develop interventive therapeutic approaches to
prevent or treat such infections.
Recent
Publications
Daley, J.K., L.A. Gechman, J. Skipworth, G.
F. Rall. Poliovirus replication and spread in primary neuron
cultures. Virology, 340: 10-20, 2005.
Matullo, C.K., G. F. Rall. “Immunological
wrong turns in the face of multiple viral infections.”
Future Virology (launch issue), 1: 37-45, 2006.
Patterson, C.E., Daley, J.K., Echols, L.A.,
Lane, T.E., Rall, G.F. Measles virus infection induces chemokine
synthesis by neurons. J. Immunol. 171:3102-3109,
2003.
Rall, G.F. "Measles virus 1998-2002: progress
and controversy." Annual Reviews of Microbiology,
57: 343-367, 2003.
Patterson, C. E., D. M. Lawrence, L. A. Echols,
G. F. Rall. Immune-mediated protection from measles virus-induced
CNS disease is noncytolytic and interferon gamma-dependent.
J. Virol. 76:4497-4506, 2002.
Lab
Rotation
Projects for 2006-2007
- Basis of age-dependent susceptibility to
CNS infection by measles virus in a transgenic mouse model.
- Mechanisms of chemokine production by neurons
following virus infection
- Lab
personnel:
- Wes Rose, Postdoc
Virginia Young, Postdoctoral Fellow
Christine Matullo, Grad student (TJU)
Lisa Gechman, Sci Tech II
Jason Skipworth, Sci Tech I
last updated 8/2006
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