Christoph Seeger
Ph.D. Senior Member, Fox Chase Cancer Center

Microbiology, Virology and Parasitology Program

Address

Fox Chase Cancer Center
333 Cottman Avenue
Philadelphia, PA 19111-2497
Office tel. 215 728 4312
Lab tel. 215 728 4313

Fax: 215 728 4329
E-mail: seeger@fccc.edu

Link(s)

Dr. Seeger's FCCC web page

Education

University of Basel,Switzerland, Diplom in Molecular Biology, Virology, 1979

University of Basel, Switzerland, Ph.D. (Virology)1982

Research Interests

• Animal viruses, viral pathogenesis, innate immunity.

Key words: hepatitis virus, interferon.

Search PubMed for articles

Description of Research

Our laboratory focuses on the replication and pathogenesis of hepatitis B and C viruses (HBV, HCV). Both viruses cause chronic infections that can lead to the development of liver cirrhosis and liver cancer. We are investigating host-virus interactions that are important for the replication and maintenance of HBV and HCV genomes in infected hepatocytes. We are particularly interested in the cellular antiviral programs that impinge on the life cycles of these viruses. For our studies we are applying established molecular approaches in combination with genomics and bioinformatics. In addition, we are beginning investigations of the HCV-related West Nile and Dengue viruses, which will allow us to exploit information forthcoming from the mouse genome project for studies on host-virus interactions and pathogenesis in an established animal model.

Recent Publications

Evans, J.D., Seeger, C. Cardif: A protein central to innate immunity is inactivated by the HCV NS3 serine protease. Hepatology 43:615-617, 2006

Seeger, C. Salient molecular features of hepatitis C virus revealed. Trends Microbiol. 13:528-534, 2005.

Guo, J.-T., Hayashi, J., and Seeger, C. (2005) West Nile virus inhibits the signal transduction pathway of alpha interferon. J. Virol. 79:1343-1350.

Hayashi, J., Stoyanova, R., and Seeger, C. (2005) The transcriptome of HCV replicon expressing cell lines in the presence of alpha interferon. Virology 335:264-275.

Guo, J.-T., Zhu, Q., and Seeger, C. (2003) Cytopathic and noncytopathic interferon responses in cells expressing hepatitis C virus subgenomic replicons. J. Virol. 77:10769-10779.

Lab

Rotation Projects for 2006-2007

The subjects of rotation projects are the innate immune response against hepatitis C and West Nile viruses.

Lab personnel:

Jared Evans, Ph.D., Postdoctoral Fellow
David Li, M.Sc., Scientific Technician
Ji A. Sohn, B.S., Scientific Technician
Paul Gramlich, B.S., Scientific Techician
David Stiffler, Student