Genetics of Diabetes and Metabolism
The following GGR laboratories are interested in genetics of diabetes and metabolism
|Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
||Regulation of gene expression and metabolism by nuclear hormone receptors.
|| The goal of our research is to understand metabolism and metabolic
regulation in both normal physiology and disease states and apply this
knowledge to human health and medicine.
||Nuclear receptors, transcription factors, lipid metabolism, genetic variation, Fatty liver disease, metabolic syndrome, obesity, diabetes
||Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Other CAMB laboratories (with research related to GGR) interested in genetics of diabetes and metabolism
||Neuroendocrine regulation of body weight and glucose.
||The regulation of growth and metabolism
||Elucidating the critical role of the tumor suppressor Menin in regulation of cell proliferation, leukemia and diabetes; investigating signal transduction and epigenetics co-regulated by transforming growth factor beta (TGF-ß) and Menin.
|| * Development of the vertebrate digestive system
* Biology and physiology of digestive epithelia and cancers
* High throughput small molecule drug screens
||Genetic regulation of lipid and lipoprotein metabolism and molecular relationship to atherosclerosis.
||We are particularly interested in early determination and specification
events; this involves the commitment of mesenchymal stem cells to a
preadipose cell fate. We are also exploring pathways that determine the
fate (and thus the function) of different types of fat cells.
||My lab is studying cellular metabolism, particularly how metabolic
pathways regulate signal transduction and gene expression in cancer and
||Signaling mechanisms of insulin secretion. Cytokines and diabetes.
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