C elegans |
The following GGR laboratories work with C. elegans
| Eric Moss | Developmental timing, microRNA function, post-transcriptional regulation of gene expression, developmental genetics of C. elegans. |
| John Murray | Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging |
| David Raizen | The regulation and purpose of sleep-like behavior in C. elegans. |
| Meera Sundaram | Regulation and targets of Ras/ERK signaling in C. elegans |
Other CAMB laboratories (with research related to GGR) that work with C. elegans.
| Todd Lamitina | Molecular mechanisms of environmental stress sensing and signaling. |
Drosophila |
The following GGR laboratories work with drosophila
| Michael Atchison | Control of Gene Expression, development, and oncogenesis. |
| Thomas Jongens |
Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification |
| Amita Sehgal |
Molecular basis of behavior |
| Jumin Zhou | Mechanism of epigenetic inheritance, long-range transcription activation, insulator and anti-insulators. |
Other CAMB laboratories (with research related to GGR) that work with drosophila
| Signaling mechanisms that function during attractive and repulsive axon guidance. | |
| Morris Birnbaum |
The regulation of growth and metabolism. |
| Sara Cherry | Genetic and mechanistic studies of viral-host interactions. |
| Steve Dinardo | Stem cell function; developmental patterning. |
| Amin Ghabrial | How cells make and shape tubular organs |
| Greg Guild | Shaping Drosophila cells with the actin cytoskeleton. |
Mouse |
The following GGR laboratories work with mice
| (Edwin) Ted Abel |
The molecular basis of synaptic plasticity, learning and memory; the molecular basis of sleep/wake regulation. |
| Michael Atchison |
Control of Gene Expression, development, and oncogenesis. |
| Edward S. Brodkin | Genetic analysis of social behaviors (aggressive and affiliative behaviors) and related brain phenotypes in mouse models relevant to autism and schizophrenia. |
| Douglas Epstein |
Regulation of Sonic hedgehog signaling in development and disease |
| Nancy Cooke |
The role of chromatin structure in eukaryotic gene regulation. |
| David L. Gasser |
Genes that affect the immune response |
| Joshua R. Friedman |
Liver development, biliary disease |
| Brett Kaufman |
The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission. |
| Frank Lee |
Molecular mechanisms of the hypoxic response. |
| Nina Luning Prak |
mobile DNA, rearrangement of immunoglobulin genes, regulation of L1 retrotransposition |
| Kazuko Nishikura |
RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation. |
| John R. Pehrson |
Role of histone variants in regulating chromatin structure and function |
| J. Eric Russell |
Control and function of human embryonic globin genes. |
| Doris Stoffers |
Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin. |
| Mitchell Weiss |
Developmental Hematopoiesis concentrating on red blood cell and megakaryocyte lineages. |
| Kenneth Zaret |
Mammalian gene regulation, cell differentiation, chromatin structure. |
| Zhaolan (Joe) Zhou | Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease |
Other CAMB laboratories (with research related to GGR) that work with mice
| Marisa Bartolomei | Genomic imprinting and X inactivation in mice. |
| Eric Brown | Role of DNA damage responses in preserving genome integrity and preventing cancer. |
| Lewis Chodosh | Genetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging. |
| E. Bryan Crenshaw | Analysis of the role of developmental regulatory factors during mouse embryogenesis. |
| Tom Curran | The molecular basis of normal and neoplastic growth formation of the brain to uncover new approaches for the treatment of pediatric brain tumors. |
| Jonathan Epstein | Transcriptional regulation of cardiac development and function using mouse models. |
| Xianxin Hua | The critical role of the tumor suppressor Menin in regulation of cell proliferation, apoptosis, and genome stability. Signal transduction mediated by transforming growth factor beta (TGF-b). |
| Olena Jacenko | Molecular mechanisms of skeletal development and blood cell differentiation. |
| Brad Johnson | Molecular biology of aging, Werner syndrome, telomeres, recombination. |
| Anna Kashina | Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis. |
| Klaus Kaestner | Dr. Kaestner’s lab is employing modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. |
| Catherine Lee May | Transcriptional regulation of pancreas and gastrointestinal development and function using mouse models. |
| Sarah Millar | Intercellular signals regulating the development of hair follicles, teeth and mammary glands and postnatal hair growth. |
| Ed Morrisey | Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors. |
| Michael Parmacek | Transcriptional programs that regulate cardiovascular development. |
| Daniel Rader | Genetic regulation of lipid and lipoprotein metabolism and molecular relationship to atherosclerosis. |
| Susan Ross | Genetic approaches to the study of host-virus interactions. |
| Anil Rustgi | Oncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI). |
| Richard Schultz | Egg activation and gene expression in mouse embryos. |
| Celeste Simon | Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation. |
| Ben Stanger | Organogenesis, Stem Cells, Pancreatic Cancer, Regulation of Organ Size. |
Plants |
The following GGR laboratories work with plants
| Doris Wagner |
Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues. |
Other CAMB laboratories (with research related to GGR) that work with plants
| Scott Poethig | Regulation of developmental timing and organ polarity in plants. |
S. cerevisiae |
The following GGR laboratories work with S. cerevisiae
| Shelley Berger |
Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection. |
| Aaron D. Gitler | Genetic and cellular mechanisms of neurodegeneration |
| Hillary Nelson |
Regulation of the heat shock transcription factor |
Other CAMB laboratories (with research related to GGR) that work with S. cerevisiae
| Erfei Bi | Development of cell polarity and control of cytokinesis in budding yeast. |
| Chris Burd | ARF GTPases, Rab GTPases, endocytosis, secretion, phosphatidylinositol kinase signaling. |
| Andrew Dancis | Iron transport into mitochondria, Heme sythesis, Fe-S cluster biogenesis, Yeast genetics, and Sideroblastic anemia |
| Wei Guo | The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis. |
| Brad Johnson | Molecular biology of aging, Werner syndrome, telomeres, recombination. |
| Frank Luca | Yeast and mammalian cell cycle regulation; Cytokinesis. Daughter cell-specific gene expression; Polarized growth Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM). |
Zebrafish |
The following GGR laboratories work with zebrafish
| Aaron D. Gitler | Genetic and cellular mechanisms of neurodegeneration |
Other CAMB laboratories (with research related to GGR) that work with zebrafish
| Jonathan Epstein | Transcriptional regulation of cardiac development and function using mouse models |
| Michael Granato | Axonal guidance and motor behavior regulation in the zebrafish. |
| Dan Kessler | * Establishment and organization of the primary germ layers * Formation and function of the Spemann organizer in axial development * Signaling and transcriptional networks in the vertebrate gastrula |
| Ed Morrisey | lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors |
| Mary Mullins | BMP signal transduction; molecular mechanisms of cell specification establishment of the vertebrate body plan via maternal control mechanisms. |
| Michael Pack | Genetic analysis of vertebrate digestive organ development using the zebrafish. |
| Jonathan Raper | developmental neurobiology, especially axon guidance |
| Eric Weinberg | Pattern formation, neural development, ear development in the zebrafish embryo. |
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