Cell & Molecular Biology Graduate Group

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Genetics of Model Organisms


C elegans


The following G&E laboratories work with C. elegans

Nancy Bonini Molecular genetics of neurodegenerative disease.
Brian Gregory RNA silencing, RNA degradation, RNA stability, microRNAs, small RNAs
John Murray Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging
David Raizen The regulation and purpose of sleep-like behavior in C. elegans.
Arjun Raj RNA systems biology, particular as related to non-coding RNAs and cancer biology.
Meera Sundaram

Regulation and targets of Ras/ERK signaling in C. elegans



The following G&E laboratories work with drosophila

Michael Atchison Control of Gene Expression, development, and oncogenesis.
Thomas Jongens
Modeling Fragile X Mental Retardation in Drosophila; Germ Cell Specification
Eric Joyce Form and function of nuclear compartments and chromosome positioning
Shawn Little Transcription dynamics; Cell fate specification; RNA production, processing, transport, localization
Amita Sehgal
Molecular basis of behavior

Other CAMB laboratories (with research related to G&E) that work with drosophila

Greg Bashaw

Signaling mechanisms that function during attractive and repulsive axon guidance.
Morris Birnbaum
The regulation of growth and metabolism.
Sara Cherry Genetic and mechanistic studies of viral-host interactions.
Steve Dinardo Stem cell function; developmental patterning.
Amin Ghabrial How cells make and shape tubular organs
Greg Guild Shaping Drosophila cells with the actin cytoskeleton.



The following G&E laboratories work with mice

Michael Atchison
Control of Gene Expression, development, and oncogenesis.
Ben Black

Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes

Edward S. Brodkin Genetic analysis of social behaviors (aggressive and affiliative behaviors) and related brain phenotypes in mouse models relevant to autism and schizophrenia.
Douglas Epstein
Regulation of Sonic hedgehog signaling in development and disease
David L. Gasser
Genes that affect the immune response
Eric Joyce Form and function of nuclear compartments and chromosome positioning
Yana Kamberov

Evolution of human specific traits; Genetics of skin appendage development and evolution; Mouse models to understand the functional significance of adaptive genetic changes;identification and functional testing of regulatory elements driving human evolution

Brett Kaufman
The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission.
Frank Lee
Molecular mechanisms of the hypoxic response.
Nina Luning Prak
mobile DNA, rearrangement of immunoglobulin genes, regulation of L1 retrotransposition
Kazuko Nishikura
RNA metabolism/processing. RNA editing, RNAi mechanism, apoptosis, cell cycle regulation.
Aimee Payne *Genetic and functional characterization of human autoantibody repertoires
*Targeted therapy for pemphigus
*Regulation of desmosome assembly and disassembly
John R. Pehrson
Role of histone variants in regulating chromatin structure and function
J. Eric Russell
Control and function of human embryonic globin genes.
Doris Stoffers
Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Katalin Susztak Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development
Mitchell Weiss
Developmental Hematopoiesis concentrating on red blood cell and megakaryocyte lineages.
Kenneth Zaret
Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan (Joe) Zhou Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease

Other CAMB laboratories (with research related to G&E) that work with mice

Marisa Bartolomei Genomic imprinting and X inactivation in mice.
Eric Brown Role of DNA damage responses in preserving genome integrity and preventing cancer.
Lewis Chodosh Genetically engineered mouse models for breast cancer; Cancer stem cells; Molecular therapeutics; Genomics; Non-invasive imaging.
E. Bryan Crenshaw Analysis of the role of developmental regulatory factors during mouse embryogenesis.
Tom Curran The molecular basis of normal and neoplastic growth formation of the brain to uncover new approaches for the treatment of pediatric brain tumors.
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models.
Xianxin Hua The critical role of the tumor suppressor Menin in regulation of cell proliferation, apoptosis, and genome stability.
Signal transduction mediated by transforming growth factor beta (TGF-b).
Olena Jacenko Molecular mechanisms of skeletal development and blood cell differentiation.
Brad Johnson Molecular biology of aging, Werner syndrome, telomeres, recombination.
Anna Kashina Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis.
Klaus Kaestner Dr. Kaestner’s lab is employing modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Sarah Millar Intercellular signals regulating the development of hair follicles, teeth and mammary glands and postnatal hair growth.
Ed Morrisey Lung development, cardiac development, vascular development, Wnt signaling, regulation of gene transcription, GATA factors, forkhead factors.
Michael Parmacek Transcriptional programs that regulate cardiovascular development.
Daniel Rader Genetic regulation of lipid and lipoprotein metabolism and molecular relationship to atherosclerosis.
Susan Ross Genetic approaches to the study of host-virus interactions.
Anil Rustgi Oncogenes, tumor suppressor genes, molecular genetics of GI cancers (colon, pancreatic, upper GI).
Richard Schultz Egg activation and gene expression in mouse embryos.
Celeste Simon Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.
Nancy Speck Hematopoietic stem cells and leukemia using mouse models
Ben Stanger Organogenesis, Stem Cells, Pancreatic Cancer, Regulation of Organ Size.



The following G&E laboratories work with plants

Brian Gregory RNA silencing, RNA degradation, RNA stability, microRNAs, small RNAs
Doris Wagner

Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.

Other CAMB laboratories (with research related to G&E) that work with plants

Scott Poethig Regulation of developmental timing and organ polarity in plants.

S. cerevisiae


The following G&E laboratories work with S. cerevisiae

Shelley Berger

Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection.

Other CAMB laboratories (with research related to G&E) that work with S. cerevisiae

Erfei Bi Development of cell polarity and control of cytokinesis in budding yeast.
Andrew Dancis Iron transport into mitochondria, Heme sythesis, Fe-S cluster biogenesis, Yeast genetics, and Sideroblastic anemia
Wei Guo The molecular basis for polarized exocytosis and how exocytosis contributes to polarized cell growth and morphogenesis.
Brad Johnson Molecular biology of aging, Werner syndrome, telomeres, recombination.
Frank Luca Yeast and mammalian cell cycle regulation; Cytokinesis.
Daughter cell-specific gene expression; Polarized growth
Mitotic Exit Network (MEN); Regulation of Ace2-dependent transcription and Morphogenesis (RAM).


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