Cell & Molecular Biology Graduate Group

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Bioinformatics and Genomics

The following G&E laboratories are interested in bioinformatics and genomics.

Yoseph Barash The lab develops machine learning algorithms that integrate high-throughput data (RNASeq, CLIPSeq , PIPSeq, etc.) to infer RNA biogenesis and function, followed by experimental verifications of inferred mechanisms.
Ben Black

Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes

Andres Blanco I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Roberto Bonasio Molecular mechanisms of epigenetic memory
Noncoding RNAs
Chromatin biochemistry
Christopher Brown We are currently focused on massively parallelizing assays that interrogate non-coding DNA function and applying these approaches to the fine-mapping of the causal variants underlying human disease.
Maja Bucan
Genetic dissection of complex behaviors in mice; Functional genomics
Brian Capell Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Russ Carstens
Study of the molecular mechanisms of alternative splicing.
Alice Chen-Plotkin I am interested in neurogenerative diseases; my research approach uses genomic-scale screens to identify leads for downstream mechanistic follow-up in cell culture systems.
Jennifer Phillips-Cremins Epigenetics | Genomics | Systems and Synthetic Bioengineering | Experimental Neuroscience | Molecular and Cellular Engineering
Robert Faryabi Model interplay between mutated transcriptional regulators and epigenetic dysregulation in cancer
Alessandro Gardini The Gardini lab investigates how global transcription is regulated during cell differentiation and oncogenesis using a variety of genomics and biochemistry approaches
Struan Grant My current work continues to primarily investigate disease genomics, with a specific focus on pediatrics
Casey Greene big data, integrative genomics, precision medicine, bioinformatics, transcriptomics
Hakon Hakonarson Genetics of common and rare human diseases, using high-throughput sequencing and genotyping approaches.
Eric Joyce Form and function of nuclear compartments and chromosome positioning
Klaus Kaestner
Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
John Murray Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging
Raymond Soccio Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes
Doris Stoffers Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Kai Tan Model gene regulatory networks in development and disease
Golnaz Vahedi Epigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning
Benjamin Voight Using statistical genetics, population genetics, and computational biology toward understanding the biological underpinnings and evolutionary history of human phenotypes
Doris Wagner
Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Jeremy Wilusz Regulation of noncoding RNA biogenesis and function
Kenneth Zaret Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan (Joe) Zhou Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease

Other CAMB laboratories (with research related to G&E) interested in bioinformatics and genomics.

Frederic Bushman Virology, HIV, Poxviruses, DNA modifying enzymes, Lateral DNA transfer.
Sara Cherry Genetic and mechanistic studies of viral-host interactions.
David Roos Molecular parasitology, host-pathogen interactions, drug targets & resistance mechanisms, evolution of eukaryotic cells & organellar function, genome databases & database mining, comparative genomics, computational biology, Toxoplasma gondii, Plasmodium falciparum.
Jun Zhu Quorum Sensing, Bacterial pathogenesis, Biofilms, Vibrio cholerae.

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