Cell & Molecular Biology Graduate Group

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Epigenetics and Chromatin

The following G&E laboratories are interested in epigenetics and chromatin

Michael Atchison
Control of Gene Expression, development, and oncogenesis.
Shelley Berger
Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection.
Ben Black

Chromosome inheritance in somatic cells and through the germline, epigenetic and genetic contributions at mammalian centromeres, chromatin structural biochemistry and biophysics, chromatin complexes that signal errors in cell division and DNA damage during the rest of the cell cycle, chromatin assembly, mass spec-based proteomics and biophysical studies of chromosome complexes

Andres Blanco I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Gerd Blobel

Hematopoiesis, gene expression, transcription factors, chromatin

Roberto Bonasio Molecular mechanisms of epigenetic memory
Noncoding RNAs
Chromatin biochemistry
Christopher Brown We are currently focused on massively parallelizing assays that interrogate non-coding DNA function and applying these approaches to the fine-mapping of the causal variants underlying human disease.
Brian Capell Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Maya Capelson *Nuclear structure and its role in gene regulation
*Spatial organization of the genome
*Epigenetic memory of gene expression states
Jennifer Cremins The Cremins lab investigates the link between three-dimensional organization of genomes and the establishment and maintenance of cellular function.
Hua-Ying Fan Chromatin structure regulation by ATP-dependent chromatin remodelers and its impact on disease; Mechanisms of transcription memory.
Robert Faryabi

Model interplay between mutated transcriptional regulators and epigenetic dysregulation in cancer

Alessandro Gardini The Gardini lab investigates how global transcription is regulated during cell differentiation and oncogenesis using a variety of genomics and biochemistry approaches
Eric Joyce Form and function of nuclear compartments and chromosome positioning
Klaus Kaestner
Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Jennifer Kalish Understanding and improving detection of epigenetics and mosaicism in human disease
Brett Kaufman
The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission.
Mitchell Lazar
Regulation of gene expression and metabolism by nuclear hormone receptors.
Stephen Liebhaber
Roles of chromatin structure and epigenetic controls in eucaryotic gene activation; Roles of mRNA-protein interactions in control of eucarytic mRNA stability and expression.
John Murray Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging
John R. Pehrson
Role of histone variants in regulating chromatin structure and function
Kavitha Sarma RNA interactions in epigenetic gene regulation and genome organization
Eileen M. Shore
Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.

Rebecca Simmons


Developmental programming of adult disease (diabetes, obesity); ß-cell development; role of epigenetics in fetal programming and early embryo/placenta development

Raymond Soccio Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes
Doris Stoffers
Transcription factors and signal transduction; Embryonic development and adult regeneration of the endocrine pancreas; Relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Kai Tan Model gene regulatory networks in development and disease
Golnaz Vahedi Epigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning
Doris Wagner
Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Hao Wu Epigenomics, DNA methylation and demethylation, Transcriptional control, Single cell analysis, Stem cell biology, Neural and cardiac lineage specification and maturation
Kenneth Zaret
Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan Zhou Epigenetic Control of Genome Function in Brain Development and Disease

Other CAMB laboratories (with research related to G&E) interested in epigenetics and chromatin

Marisa Bartolomei Genomic imprinting and X inactivation in mice.
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models.
Peter Klein Early vertebrate development, Wnt signal transduction, neuropharmacology of lithium action
John McLaughlin genomic imprinting, somatic cell reprogramming, embryonic stem cells
Steve Reiner Transcriptional control of lymphocyte differentiation.
Gene silencing, chromatin structure and DNA methylation.
Richard Schultz Egg activation and gene expression in mouse embryos.

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