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Cell and Molecular Biology Graduate Group


Signal Transduction

 

The following laboratories are interested in signal transduction

Charles Abrams

Phospholipid signaling in platelet and T-cells.

Yair Argon
Functions of molecular chaperones in the immune system - modulation of antigen receptors expression and of peptide presentation.
Richard Assoian

Signal transduction and cell cycle control.
Morris Birnbaum

The regulation of growth and metabolism.
Lawrence F. Brass
Mechanisms of thrombosis.
Janis Burkhardt

Regulation and function of the T cell cytoskeleton.
Margaret Chou
Mechanisms of malignant transformation; signaling by small GTPases; regulation of vesicular trafficking; ubiquitination.
Dennis Discher
Cell and nuclear membrane structure-function; Adhesion mechanisms and responses of cells; Phagocyte recognition processes; Membrane skeleton and cytoskeleton; Diseases ranging from muscular dystrophy to anemias to athersclerosis; Drug delivery.
J. Kevin Foskett

Ion channels, calcium signaling, cystic fibrosis.

Gary Koretzky
Role of adaptor proteins in immune cell develoment and function; Signals leading to T cell activation and termination of T cell responses; In vitro and in vivo function of mast cells and neutrophils; Signals leading to specification of blood vessels and lymphatics.
Mark Kahn Signaling pathways in angiogenesis and hemostasis.
Jake Kushner
Cell cycle, transcriptional regulation of development, adult beta-cell replication.
Paul Janmey

Cytoskeleton, phosphoinositide signalling, cell mechanics.
Mark Lemmon
Signaling by growth factor receptor tyrosine kinases, and inositol phospholipid signaling - biochemical, cellular, and structural biological studies.
Judith Meinkoth
Signal transduction, proliferation, differentiation, apoptosis.
Jordan S. Orange
Directed secretion at the cytolytic immunological synapse; Role of NF-kB activation in cytolytic function
Alan D. Schreiber
Molecular and cell biology of Fc receptors: Mechanisms of function and role in phagocytosis and immune clearance.
Rebecca Wells
TGF-ß receptor biology; Hepatic stellate cell function in liver fibrosis.
Bryan A. Wolf

Signaling mechanisms of insulin secretion; Cytokines and diabetes.

 

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