Using modern genetic approaches
(expression profiling, gene targeting, tissue-specific
and inducible gene ablation) to understand the molecular
mechanisms of organogenesis and physiology of the liver,
pancreas and gastrointestinal tract.
Transcription factors and
signal transduction; Embryonic development and adult regeneration
of the endocrine pancreas; Relationship of defects in
these pathways to the pathophysiology of diabetes mellitus,
a disease caused by a deficiency in the production or
action of insulin.
