Our research interests are
focused broadly on the molecular pathways governing cellular
growth control and their disruption during the initiation
and progression of human cancers.
Transcription factors and
signal transduction; Embryonic development and adult regeneration
of the endocrine pancreas; Relationship of defects in
these pathways to the pathophysiology of diabetes mellitus,
a disease caused by a deficiency in the production or
action of insulin.
Elucidation of
molecular mechanisms which regulate the initiation and
proper repair of DNA double strand breaks during chromosomal
V(D)J recombination.
The role of oxygen, the VHL
tumor suppressor and HIF in cell growth and apoptosis,
angiogenesis and extracelluar matrix formation/fibrosis;
Kidney cancer and ischemic cell injury; Podocyte biology,
von Hippel-Lindau disease (VHL); Conditional gene targeting
technology and transgenesis; Embryonic stem (ES) cells;
Mouse model systems.
