Cell & Molecular Biology Graduate Group

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Transcriptional Gene Regulation

The following G&E laboratories are interested in transcriptional gene regulation

Michael Atchison
Control of Gene Expression, development, and oncogenesis.
Shelley Berger
Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection.
Andres Blanco I study the mechanisms by which epigenetic information is encoded, interpreted, and propagated in normal and pathological (eg. cancerous) cell identity programs.
Gerd Blobel

hematopoiesis, gene expression, transcription factors, chromatin

Roberto Bonasio Molecular mechanisms of epigenetic memory
Noncoding RNAs
Chromatin biochemistry
Christopher Brown We are currently focused on massively parallelizing assays that interrogate non-coding DNA function and applying these approaches to the fine-mapping of the causal variants underlying human disease.
Brian Capell Our lab seeks to understand how epigenetic and chromatin-based transcriptional regulatory mechanism contribute to carcinogenesis and aging, utilizing the skin as our model system.
Russ Carstens
Study of the molecular mechanisms of alternative splicing.
Douglas Epstein
Regulation of Sonic hedgehog signaling in development and disease
Hua-Ying Fan Chromatin structure regulation by ATP-dependent chromatin remodelers and its impact on disease; Mechanisms of transcription memory.
Robert Faryabi

Model interplay between mutated transcriptional regulators and epigenetic dysregulation in cancer

Benjamin Garcia Quantitative Mass Spectrometry Based Proteomics for Characterizing Modified Proteins and Proteomes
Alessandro Gardini The Gardini lab investigates how global transcription is regulated during cell differentiation and oncogenesis using a variety of genomics and biochemistry approaches.
Donna L. George Our research interests are focused broadly on the molecular pathways governing cellular growth control and their disruption during the initiation and progression of human cancers.
Casey Greene

Our overarching goal is to transform how we understand complex biological systems by developing and applying computational algorithms that effectively model processes by integrating multiple types of big data from diverse experiments.

Eric Joyce Form and function of nuclear compartments and chromosome positioning
Klaus Kaestner
Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Yana Kamberov Evolution of human specific traits; Genetics of skin appendage development and evolution; Mouse models to understand the functional significance of adaptive genetic changes;identification and functional testing of regulatory elements driving human evolution
Brett Kaufman
The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission.
Mitchell Lazar
Regulation of gene expression and metabolism by nuclear hormone receptors.
Frank Lee
Molecular mechanisms of the hypoxic response.
Stephen Liebhaber
Roles of chromatin structure and epigenetic controls in eucaryotic gene activation; Roles of mRNA-protein interactions in control of eucarytic mRNA stability and expression.
Shawn Little Transcription dynamics; cell fate specification; RNA production, processing, transport, localization
Ronen Marmorstein Biochemical, biophysical and X-ray crystallographic techniques are employed to study the posttranslational modification of histones and other proteins and the misregulation of such modifications in cancer and metabolic disorders.
John Murray Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging
John R. Pehrson
Role of histone variants in regulating chromatin structure and function
Jennifer Phillips-Cremins Epigenetics | Genomics | Systems and Synthetic Bioengineering | Experimental Neuroscience | Molecular and Cellular Engineering
Kavitha Sarma RNA interactions in epigenetic gene regulation and genome organization
Eileen M. Shore
Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.
Rebecca Simmons

Developmental programming of adult disease (diabetes, obesity); ß-cell development; role of epigenetics in fetal programming and early embryo/placenta development

Raymond Soccio

Nuclear receptors, transcription factors, lipid metabolism, genetic variation, fatty liver disease, metabolic syndrome, obesity, diabetes

Meera Sundaram
Regulation and targets of Ras/ERK signaling in C. elegans
Kai Tan Model gene regulatory networks in development and disease
Golnaz Vahedi Epigenetics, Immunology, Human Genetics, Bioinformatics, Computational Biology, Machine-learning
Doris Wagner
Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Kenneth Zaret
Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan (Joe) Zhou Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease

Other CAMB laboratories (with research related to G&E) interested in transcriptional gene regulation.

Frederic Barr Rhabdomyosarcoma (a cancer of the muscle lineage), chromosomal translocations, paired box transcription factors.
Marisa Bartolomei Genomic imprinting and X inactivation in mice.
Maya Capelson *Nuclear structure and its role in gene regulation
*Spatial organization of the genome
*Epigenetic memory of gene expression states
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models.
Brian Keith How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
Melike Lakadamyali Super-resolution imaging of chromatin structure and epigenetic regulation of gene activity
Mike May NF-kB signaling in inflammation and cancer.
Michael Parmacek Transcriptional programs that regulate cardiovascular development.
Celeste Simon Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.

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