The following GGR laboratories are interested in transcriptional gene regulation
| (Edwin) Ted Abel |
The molecular basis of synaptic plasticity, learning and memory; the molecular basis of sleep/wake regulation. |
| Michael Atchison |
Control of Gene Expression, development, and oncogenesis. |
| Shelley Berger |
Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection. |
| Gerd Blobel |
hematopoiesis, gene expression, transcription factors, chromatin |
| Russ Carstens |
Study of the molecular mechanisms of alternative splicing. |
| Nancy Cooke |
The role of chromatin structure in eukaryotic gene regulation. |
| Douglas Epstein |
Regulation of Sonic hedgehog signaling in development and disease |
| Hua-Ying Fan | Chromatin structure regulation by ATP-dependent chromatin remodelers and its impact on disease; Mechanisms of transcription memory. |
| Joshua R. Friedman |
Liver development, biliary disease |
| Donna L. George | Our research interests are focused broadly on the molecular pathways governing cellular growth control and their disruption during the initiation and progression of human cancers. |
| Susan Janicki |
Live cell analysis of epigenetic regulatory mechanisms. |
| Klaus Kaestner |
Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. |
| Brett Kaufman |
The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission. |
| Mitchell Lazar |
Regulation of gene expression and metabolism by nuclear hormone receptors. |
| Frank Lee |
Molecular mechanisms of the hypoxic response. |
| Stephen Liebhaber |
Roles of chromatin structure and epigenetic controls in eucaryotic gene activation; Roles of mRNA-protein interactions in control of eucarytic mRNA stability and expression. |
| John Murray | Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging |
| Hillary Nelson |
Regulation of the heat shock transcription factor |
| John R. Pehrson |
Role of histone variants in regulating chromatin structure and function |
| Eileen M. Shore |
Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes. |
| Meera Sundaram |
Regulation and targets of Ras/ERK signaling in C. elegans |
| Doris Wagner |
Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues. |
| Mitchell Weiss |
Developmental Hematopoiesis concentrating on red blood cell and megakaryocyte lineages. |
| Kenneth Zaret |
Mammalian gene regulation, cell differentiation, chromatin structure. |
| Jumin Zhou | Mechanism of epigenetic inheritance, long-range transcription activation, insulator and anti-insulators. |
| Zhaolan (Joe) Zhou | Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease |
Other CAMB laboratories (with research related to GGR) interested in transcriptional gene regulation.
| Frederic Barr | Rhabdomyosarcoma (a cancer of the muscle lineage), chromosomal translocations, paired box transcription factors. |
| Marisa Bartolomei | Genomic imprinting and X inactivation in mice. |
| Jonathan Epstein | Transcriptional regulation of cardiac development and function using mouse models. |
| Brian Keith | How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression. |
| Mike May | NF-kB signaling in inflammation and cancer. |
| Michael Parmacek | Transcriptional programs that regulate cardiovascular development. |
| Steven Reiner | Transcriptional control of lymphocyte differentiation. Gene silencing, chromatin structure and DNA methylation. |
| Celeste Simon | Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation. |
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