Cell & Molecular Biology Graduate Group

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Transcriptional Gene Regulation

The following GGR laboratories are interested in transcriptional gene regulation

(Edwin) Ted Abel
The molecular basis of synaptic plasticity, learning and memory; the molecular basis of sleep/wake regulation.
Michael Atchison
Control of Gene Expression, development, and oncogenesis.
Shelley Berger
Chromatin structure and function in gene regulation; post-translational modifications of transcription factors and histones; genetic, biochemical and structural analysis of chromatin in S. cerevisiae and human cells; role of interrelated factor/histone modifications in cancer and viral infection.
Gerd Blobel

hematopoiesis, gene expression, transcription factors, chromatin

Roberto Bonasio Molecular mechanisms of epigenetic memory
Noncoding RNAs
Chromatin biochemistry
Christopher Brown We are currently focused on massively parallelizing assays that interrogate non-coding DNA function and applying these approaches to the fine-mapping of the causal variants underlying human disease.
Russ Carstens
Study of the molecular mechanisms of alternative splicing.
Douglas Epstein
Regulation of Sonic hedgehog signaling in development and disease
Hua-Ying Fan Chromatin structure regulation by ATP-dependent chromatin remodelers and its impact on disease; Mechanisms of transcription memory.
Donna L. George Our research interests are focused broadly on the molecular pathways governing cellular growth control and their disruption during the initiation and progression of human cancers.
Klaus Kaestner
Using modern genetic approaches (expression profiling, gene targeting, tissue-specific and inducible gene ablation) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.
Brett Kaufman
The role of mitochondrial chromatin organization in gene expression, resistance to damage, and genome transmission.
Mitchell Lazar
Regulation of gene expression and metabolism by nuclear hormone receptors.
Frank Lee
Molecular mechanisms of the hypoxic response.
Stephen Liebhaber
Roles of chromatin structure and epigenetic controls in eucaryotic gene activation; Roles of mRNA-protein interactions in control of eucarytic mRNA stability and expression.
Ronen Marmorstein Biochemical, biophysical and X-ray crystallographic techniques are employed to study the posttranslational modification of histones and other proteins and the misregulation of such modifications in cancer and metabolic disorders.
John Murray Combinatorial control of transcription and cell fate specification, C. elegans development, cellular resolution live imaging
John R. Pehrson
Role of histone variants in regulating chromatin structure and function
Eileen M. Shore
Genetic diseases of bone formation and development; Molecular and cell biology of bone formation and osteoblast differentiation; Transcriptional activation and regulation of bone morphogenetic protein and GNAS1 target genes.
Meera Sundaram
Regulation and targets of Ras/ERK signaling in C. elegans
Doris Wagner
Molecular mechanisms controling developmental transitions in response to environmental and endogenous cues.
Mitchell Weiss
Developmental Hematopoiesis concentrating on red blood cell and megakaryocyte lineages.
Kenneth Zaret
Mammalian gene regulation, cell differentiation, chromatin structure.
Zhaolan (Joe) Zhou Epigenetic Control of Experience-dependent Gene Expression in Brain Development and Disease

Other CAMB laboratories (with research related to GGR) interested in transcriptional gene regulation.

Frederic Barr Rhabdomyosarcoma (a cancer of the muscle lineage), chromosomal translocations, paired box transcription factors.
Marisa Bartolomei Genomic imprinting and X inactivation in mice.
Maya Capelson *Nuclear structure and its role in gene regulation
*Spatial organization of the genome
*Epigenetic memory of gene expression states
Jonathan Epstein Transcriptional regulation of cardiac development and function using mouse models.
Brian Keith How cells and tissues adapt to oxygen deprivation (hypoxia) by modifying gene expression.
Mike May NF-kB signaling in inflammation and cancer.
Michael Parmacek Transcriptional programs that regulate cardiovascular development.
Celeste Simon Hematopoiesis, angiogenesis, tumorigenesis, and cellular responses to oxygen deprivation.

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