Perelman School of Medicine at the University of Pennsylvania
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Confocal micrograph illustrating high levels of TACI on an extra-follicular foci (splenic sections stained with PNA, TACI, B220)
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Confocal micrograph showing the absence of BLyS from the germinal center (splenic sections stained with PNA, BLyS, CD3ε)
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Confocal micrograph illustrating the anatomical location of germinal centers at the T-B border (PNA+ germinal center , CD3ε+ T, IgD+ B cells)
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Confocal micrograph illustrating splenic architecture with MOMA-1+ macrophage layer seperating Marginal zone B cells (IgMhiIgDlo) from the Follicular B cells (IgMloIgDhi)
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Welcome
The B Cell and Our Research
Our laboratory is currently pursuing studies focused on mechanisms of B cell homeostasis and how these impact autoimmunity and aging. These have led to the characterization of a novel receptor for BLyS, a TNF family member that controls B cell numbers and determines the stringency of B cell selection.