Perelman School of Medicine at the University of Pennsylvania
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Confocal micrograph illustrating high levels of TACI on an extra-follicular foci (splenic sections stained with PNA, TACI, B220)
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Confocal micrograph showing the absence of BLyS from the germinal center (splenic sections stained with PNA, BLyS, CD3ε)
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Confocal micrograph illustrating the anatomical location of germinal centers at the T-B border (PNA+ germinal center , CD3ε+ T, IgD+ B cells)
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Confocal micrograph illustrating splenic architecture with MOMA-1+ macrophage layer seperating Marginal zone B cells (IgMhiIgDlo) from the Follicular B cells (IgMloIgDhi)
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Publications
Cancro, Michael P.: The persistence of memory: A unique niche for IgG memory B cells. P.N.A.S. 107(29): 2737-12738, July 2010.
Shahf, G., Cancro, MP and Mehr, R.: Kinetic Modeling Reveals a Common Death Niche for Newly Formed and Mature B Cells. PLoS One 5(3): e9497, March 2010.
Parsons, R.F., K. Vivek, R. R. Redfield III , T-S Migone, M. P. Cancro, A. Naji , and H. Noorchashm: B Lymphocyte Homeostasis and BLyS Directed Immunotherapy in Transplantation. Transplantation Reviews. Elsevier 24(4): 207-221, October 2010.
M. P. Cancro: An eruption of European B cell biology. EMBO Reports (2010) 11, 653-654.
R.F. Parsons, K. Vivek, R.R. Redfield, T-S Migone, M.P. Cancro, A. Naji, and H. Noorchashm : B cell Tolerance In Transplantation: Is Repertoire Remodeling The Answer? Expert Review of Clinical Immunology 5(6): 703-723 (21), November 2009.
BLyS Ligands and Receptors. {BLyS Ligands and Receptors}. Michael P. Cancro (eds.). Humana Press, Page: 284 pages, October 2009.
Cancro, Michael P.: Signaling crosstalk in B cells: managing worth and need. Nature Reviews Immunology 9(9): 657-661, September 2009.
Zhu P, Liu X, Treml LS, Cancro MP, Freedman BD.: Mechanism and Regulatory Function of CpG Signaling via Scavenger Receptor B1 in Primary B Cells. J. Biol. Chem. 284(34): 22878-87, August 2009.
Cancro, M.P, Hao, Y., Scholz, J.L., Riley, R., Frasca, D., Dunn-Walters, D., Blomberg, B.: Aging B cells: Molecules and mechanisms. Trends in Immunology 30(7): 313-318, July 2009.
Cancro, M.P., Khamashta, M.A., D'Cruz, D.P.: The role of B-lymphocyte stimulator (BLyS) in systemic lupus erythematosus. J. Clin. Invest. 119(5): 1066-1073, May 2009.