Perelman School of Medicine at the University of Pennsylvania

Capell Lab

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SELECTED PUBLICATIONS

Histone modifiers: Dynamic regulators of the cutaneous transcriptome
Ghosh K, O'Neil K, Capell BC. Histone modifiers: Dynamic regulators of the cutaneous transcriptome. Journal of Dermatological Science. Dec 18: 2017.

Cytoplasmic chromatin triggers inflammation in senescence and cancer
Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL. Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature. 550(7676): 2017.

The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging
Ghosh K, Capell BC. The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging. Journal of Investigative Dermatology. 136(11): 2016.

MLL1 is essential for the senescence-associated secretory phenotype
Capell BC, Drake AM, Zhu J, Shah PP, Dou Z, Dorsey J, Simola DF, Donahue G, Sammons M, Rai TS, Natale C, Ridky TW, Adams PD, Berger SL. MLL1 is essential for the senescence-associated secretory phenotype. Genes & Development. 30(3): 2016.

Autophagy mediates degradation of nuclear lamina
Dou Z, Xu C, Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell BC, Drake AM, Shah PP, Catanzaro JM, Ricketts MD, Lamark T, Adam SA, Marmorstein R, Zong WX, Johansen T, Goldman RD, Adams PD, Berger SL. Autophagy mediates degradation of nuclear lamina. Nature. 527(7576): 2015.

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape 
Shah PP, Donahue G, Otte GL, Capell BC, Nelson DM, Cao K, Aggarwala V, Cruickshanks HA, Rai TS, McBryan T, Gregory BD, Adams PD, Berger SL. Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape. Genes & Development. 27(16): 2013.

Genome-wide epigenetics
Capell BC, Berger SL. Genome-wide epigenetics. Journal of Investigative Dermatology. 133(6): 2013.

From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging
Capell BC, Tlougan BE, Orlow SJ. From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging. Journal of Investigative Dermatology. 129(10): 2009.

A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model
Capell BC, Olive M, Erdos MR, Cao K, Faddah DA, Tavarez UL, Conneely KN, Qu X, San H, Ganesh SK, Chen X, Avallone H, Kolodgie FD, Virmani R, Nabel EG, Collins FS. A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model. Proceedings of the National Academy of Sciences USA. 105(41): 2008.

Mechanisms of cardiovascular disease in accelerated aging syndromes
Capell BC, Collins FS, Nabel EG. Mechanisms of cardiovascular disease in accelerated aging syndromes. Circulation Research. 101(1): 2007.

Human laminopathies: nuclei gone genetically awry
Capell BC, Collins FS. Human laminopathies: nuclei gone genetically awry. Nature Reviews Genetics. 7(12): 2006.

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome
Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS. Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proceedings of the National Academy of Sciences USA. 102(36): 2005.

Complete List of Publications