Akiva S. Cohen, Ph.D.
Associate Professor, Neurology
Dr. Cohen's principal research interest is focused on the fundamental cellular and molecular mechanisms that underlie cognitive impairments associated with traumatic brain injury. His laboratory is primarily concerned with alterations in neuronal excitability in the limbic system of the brain. This system has been shown to play a primary role in higher cognitive function, e.g., learning and memory, and is damaged in traumatic brain injury. Dr. Cohen's laboratory incorporates a variety of techniques to understand the nature and functional consequences of injury-induced alterations.
concussive brain injury, hippocampus, cognitive impairment, dietary intervention
1) Injury-induced alterations in CNS electrophysiology. Cohen AS, Pfister BJ, Schwarzbach E, Grady MS, Goforth PB, Satin LS. Prog Brain Res. 2007;161:143-69.
2) Mechanisms underlying the inability to induce area CA1 LTP in the mouse after traumatic brain injury. Schwarzbach E, Bonislawski DP, Xiong G, Cohen AS. Hippocampus. 2006;16(6):541-50.PMID: 16634077
3) Regional hippocampal alteration associated with cognitive deficit following experimental brain injury: a systems, network and cellular evaluation. Witgen BM, Lifshitz J, Smith ML, Schwarzbach E, Liang SL, Grady MS, Cohen AS. Neuroscience. 2005;133(1):1-15.
4)Dietary branched chain amino acids ameliorate injury-induced cognitive impairment. Cole JT, Mitala CM, Kundu S, Verma A, Elkind JA, Nissim I, Cohen AS. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):366-71.
5) Brain injury impairs dentate gyrus inhibitory efficacy. Bonislawski DP, Schwarzbach EP, Cohen AS. Neurobiol Dis. 2007 Jan;25(1):163-9.