Center for Brain Injury and Repair
University of Pennsylvania

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Deborah J. Watson, Ph.D.

Deborah J. Watson, PhD

Research Assistant Professor of Neurosurgery

Dr. Watson's research centers on understanding mechanisms that underlie traumatic brain injury and the development of potential therapeutic treatment strategies. We are currently elucidating mechanisms by which neurotrophins protect hippocampal neurons after traumatic brain injury. We are also studying the effect of pre-injury exercise on recovery from TBI.

Related Publications:

Royo, N., D. LeBold, S. Magge, H.I. Chen, A. Hauspurg, A. Cohen, D.J. Watson (2007) Neurotrophin-mediated neuroprotection of hippocampal neurons following traumatic brain injury is not associated with acute recovery of hippocampal function. Neuroscience 148(2): 359-70.

Royo NC, Vandenberghe LH, Ma JY, Hauspurg A, Yu L, Maronski M, Johnston J, Dichter MA, Wilson JM, Watson DJ. (2008) Specific AAV serotypes stably transduce primary hippocampal and cortical cultures with high efficiency and low toxicity. Brain Research 1190: 15-22. (Cover article)

Malik SZ, Motamedia S, Royo NC, LeBold D, Watson DJ. (2010) Identification of potentially neuroprotective genes upregulated by neurotrophin treatment of CA3 neurons in the injured brain. J Neurotrauma. 2011 Mar;28(3):415-30. Epub 2011 Jan 27.

Malik SZ, Maronski MA, Dichter MA, Watson DJ. (2012) The use of specific AAV serotypes to stably transduce primary CNS neuron cultures. Methods Mol Biol. 846:305-19.

Malik SZ, Lewis, M, Isaacs A, Haskins M, van Winkle TV, Vite CH and Watson DJ. (2012) Identification of the rostral migratory stream in the canine and feline brain. PLoS ONE, in press.

Dong Y, Watson DJ. (2012) Mechanisms of TRH neuroprotection in injured hippocampal neurons. In preparation.

Hospital of the University of Pennsylvania's Department of Neurosurgery
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