JosE L. Pascual, M.D., Ph.D., FRCS(C), FRCP(C)
Jose L. Pascual MD, PhD, FRCS(C), FRCP(C) is a clinical surgeon trained at McGill University with specialized fellowship training in trauma and critical care at the University of Pennsylvania in Philadelphia. He is the patient safety officer for the HUP Department of Surgery and serves on hospital committees to promote patient safety initiatives with residents. His clinical and research interests are in shock and head injury. His research work is shared in clinical and basic science to learn how a variety of insults including head injury and shock affect the microcirculation and how different management strategies influence their effects. This basic science work is translated into several clinical projects both retrospective and prospective evaluating the effects of different osmotherapeutic agents in traumatic brain injured patients as well as the immunemodulating effects of different resuscitation fluids in different forms of shock. Dr. Pascual is also the lead physician in a series of pedagogical efforts to train medical trainees as well as advanced practitioners in the ICU using simulation based curricula.
Selected Publications
- Seely AJE, Pascual JL, Christou NV. Science Review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance Critical Care 7: 291-307 (2003).
- Pascual JL, Maloney-Wilensky E, Reilly PM, Sicoutris C, Keutmann MK, Stein SC, LeRoux PD, Gracias VH. The effect of an institutional pathway on TBI resuscitation with 7.5% hypertonic saline. American Surgeon. Vol 74 (March 2008).
- Pascual JL, Gracias VH, LeRoux PD. Injury to the Brain in Trauma: Contemporary Principles and Therapy, Lippincott Williams & Wilkins. Philadelphia, PA: Ed. Flint, Meredith, Schwab et al (December 2008)
- Oddo M, Levine JM, Frangos S, Carrera E, Maloney-Wilenski E, Pascual JL, Kofke A, Mayer SA, Leroux PD. Effect of Osmotherapy with Mannitol and Hypertonic Saline on Brain Tissue Oxygenation in Patients with Severe Traumatic Brain Injury and Refractory Intracranial Hypertension. Submitted to Critical Care Medicine, (Oct 2008)
- Sarani B, Temple-Lykens B, Kim P, Sonnad S, Bergey M, Pascual J, Sims C, Reilly P. Factors Associated with Mortality and Brain Injury Following Fall from the Standing Position. Journal of Trauma 67(5):954-958 (Nov 2009)
- Pascual JL, Gracias VH. Fluid and Volume Status. In: LeRoux, PD, Levine, JM, Kofke, WA, eds. Monitoring in Neurocritical Care. 1st ed. Philadelphia: Elsevier; (in press, 2010).
- Salcedo E, Pascual JL. Fluid Management in Traumatic Brain Injury in Encyclopedia of Intensive Care Medicine, Heidelberg, Germany: Eds Vincent, Hall (in press).
- Pascual JL, Georgoff P, Maloney-Wilensky E, Sims C, Sarani B, Stiefel MF, LeRoux PD, Schwab CW. Reduced Brain Tissue Oxygen in Traumatic Brain injury: Are most commonly used interventions successful? (Submitted for publication to the Journal of Trauma) September 2010.
Penn Surgery
Email address: Jose.Pascual@uphs.upenn.edu