W. Andrew kofke, m.d., mba, fccm
Professor, Anesthesiology, Critical Care Medicine, Neurosurgery
Director, Neuroanesthesia
Co-Director, Hospital of the University of Pennsylvania Neurocritical Care Program
Dr Kofke graduated from Bucknell University with a BS in chemistry. While there he participated in organic research, coauthoring a paper in the Journal of Organic Chemistry. He subsequently received an MD from the University of Pittsburgh where he was exposed to the new specialties of emergency medicine and critical care medicine and worked with Peter Safar and his colleagues in early studies in neuroprotection after global brain ischemia. All through high school, college, and medical school he was active in prehospital EMS as a volunteer ambulance attendant.
Dr Kofke did his internship at Mercy Hospital of Pittsburgh, and his residency in anesthesiology and fellowship in critical care medicine at Massachusetts General Hospital.
His first faculty position was at Penn State, Hershey Medical Center. While at Penn State, working with Hawkins and Biebuyck, both prior students of Hans Krebs, he became involved in several studies of anesthetics and brain energy metabolism while clinically practicing neuroanesthesia and general critical care.
Since then he has been involved in the development and growth of the stroke program at the University of Pittsburgh, the NeuroICU programs at the University of Pittsburgh and the University of Pennsylvania and the simulation programs at West Virginia University and Penn. He has directed the neuroanesthesia programs at Penn State, Pitt WVU, and Penn and was Vice Chair of Anesthesiology at WVU.
Dr Kofke’s research interests have dealt with effects and interactions of anesthetics with brain ischemia and epilepsy, with a specific interest in characterizing opioid induced neuroexcitation and neurotoxicity. Clinical research interests have additionally included studies of transcranial Doppler Ultrasonography, XeCTCBF, genotypic susceptibility to ischemic brain damage, anesthetics for epilepsy,y and opioid neuroexcitation.
Publications
Oddo M, Levine JM, Frangos S, Carrera E, Maloney-Wilensky E, Pascual JL, Kofke WA, Mayer SA, Le Roux PD: Effect of Mannitol and Hypertonic Saline on Cerebral Oxygenation in Patients with Severe Traumatic Brain Injury and Refractory Intracranial Hypertension. Journal of Neurology Neurosurgery and Psychiatry. 80(8)916-20, August 2009.
Oddo M, Frangos S, Maloney-Wilensky E, Kofke WA, Le Roux PD, Levine JM: Effect of Shivering on Brain Tissue Oxygenation During Induced Normothermia in Patients With Severe Brain Injury. Neurocritical Care. 12(1):10-16, October 2009.
Kim MN, Durduran T, Frangos S, Edlow BL, Buckley EM, Moss HE, Zhou C, Yu G, Choe R, Maloney-Wilensky E, Wolf RL, Grady MS, Greenbert JH, Levine JM, Yodh AG, Detre JA, Kofke WA: Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults. Neurocritical Care. 12(2):173-80, April 2010.
Armstead WM, Willis Kiessling VA, Kofke WA, Vavilala M: SNP Improves Cerebral Hemodynamics During Normotension But Fails to Prevent Sex Dependent Impaired Cerebral Autoregulation During Hypotension After Brain Injury. Brain Research. 142-150, March 2010.
Weiner GM, Lacey MR, Mackenzie L, Shah DP, Frangos SG, Grady MS, Kofke WA, Levine J, Schuster J, Le Roux PD: Decompressive Craniectomy for Elevated Intracranial Pressure and Its Effect on the Cumulative Ischemic Burden and Therapeutic Intensity Levels After Severe Traumatic Brain Injury. Neurosurgery. 66(6):1-8, June 2010.
Nangunoori R, Maloney-Wilensky E, Stiefel M, Park S, Kofke WA, Levine JM, Yang W, LeRoux PD: Brain Tissue Oxygen based therapy and Outcome after Severe Traumatic Brain Injury: A Systematic Literature Review. Journal of Neurotrauma. June 2010.
Spiotta A, Stiefel M, Gracias V, Garuffe A, Kofke WA, Maloney-Wilensky E, Troxel A, Levine J, LeRoux P: Brain Tissue Oxygen Directed Management and Outcome in Patients with Severe Traumatic Brain Injury. Journal of Neurosurgery. In Press 2010.
Armstead WM, Kiessling JW, Kofke WA, Vavilala MS: Impaired Cerebral Blood Flow Autoregulation During Postraumatic Arterial Hypotension After Fluid Percussion Brain Injury is Prevented by Phenylephrine in Female but Exacerbated in Male Piglets by ERK MAPK Upregulation. Critical Care Medicine. In Press 2010.
Department of Anesthesiology and Critical Care
Email address: Andrew.Kofke@uphs.upenn.edu