William m. Armstead, Ph.D.
Reasearch Professor, Department of Anesthesia and Critical Care
Member of the Graduate Groups in Neuroscience and Pharmacology
Member, Institute of Neurological Sciences, UPenn
Member, Cardiovascular Institute, UPenn
Dr. Armstead's research focuses on characterizing mechanisms important in the control of cerebral hemodynamics under physiologic and pathologic conditions such as traumatic brain injury (TBI), stroke, and cerebral hypoxia/ischemia, particularly in the newborn. Current projects focus on interactions between the NMDA receptor and plasminogen activators after TBI, optimizing the efficacy/toxicity ratio of tPA, the only FDA approved treatment for stroke and translational research concerning the roles of sex and age in outcome after pediatric TBI.
Recent publications:
Armstead WM, T Nassar, S Akkawi, DH Smith, XH Chen, DB Cines, and AAR Higazi. Neutralizing the neurotoxic effects of exogenous and endogenous tPA.Nature Neuroscience 9: 1150-1155, 2006.
Armstead WM, and MS Vavilala. Adrenomedullin reduces gender dependent loss of hypotensive cerebrovasodilation after newborn brain injury through activation of ATP dependent Kchannels. J Cereb Blood Flow Metab, 27: 1702-1709, 2007.
Armstead WM, DB Cines, K Bdeir, I Kulikovskaya, SC Stein, A Higazi. uPA impairs cerebro-vasodilation after hypoxia/ischemia through LRP and ERK MAPK. Brain Res, 1231: 121-131, 2008.
Hospital of the University of Pennsylvania's Department of Anesthesia
Hospital of the University of Pennsylvania's Department of Pharmacology
Email address: ArmsteaW@uphs.upenn.edu