CEET: Newsworthy Items

Newsworthy Items

Public Interest

BoRit Asbestos Site Added to Superfund List
The U.S. Environmental Protection Agency today announced the addition of the BoRit Asbestos Site in Ambler, Pa. to the Superfund National Priorities List (NPL).

The Lung Cancer Enablers
Jong-Heum Park et al. illuminate one of the three pathways by which polycyclic aromatic hydrocarbons (PAHs) can be activated, showing for the first time the specific pathway for oxidative damage in human lung cell.
Evidence for the Aldo-Keto Reductase Pathway of Polycyclic Aromatic Trans-dihydrodiol Activation in Human Lung A549 Cells. Park JH, Mangal D, Tacka KA, Quinn AM, Harvey RG, Blair IA, Penning TM. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6846-51.

Tracking The Chemicals In Us: Monitoring trace chemicals in people has benefited public health, but many challenges lie ahead
LARGE-SCALE MEASUREMENTS of chemicals in human tissues, or biomonitoring, is only about two decades old. But it has already led to a revolution in how chemical exposures are assessed in humans, to new opportunities in disease detection and prevention, and to a recognition that endocrine disrupters—compounds that mimic hormones or interfere with hormonal action—in the environment may cause a variety of adverse effects.
By Bette Hileman
Chemical and Engineering News, April 23, 2007, Volume 85, Number 17, pp 32-34.

Governor Rendell Announces $17 Million Investment to Promote Health Research
The University of Pennsylvania – in association with the Pennsylvania State University Medical College and Lincoln University – will receive $4.2 million to study gene-environment interactions that increase the risk of lung cancer in African American and Caucasian smokers and non-smokers. The study will be conducted under the Gene-Environmental Initiative of the Center of Excellence in Environmental Toxicology, or CEET.

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Feature Publications

	Park JH, Gelhaus S, Vedantam S, Oliva AL, Batra A, Blair IA, Troxel AB, Field J, Penning TM. The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance. Chem Res Toxicol. 2008 May;21(5):1039-49.
	Evidence for the Aldo-Keto Reductase Pathway of Polycyclic Aromatic Trans-dihydrodiol Activation in Human Lung A549 Cells. Park JH, Mangal D, Tacka KA, Quinn AM, Harvey RG, Blair IA, Penning TM. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6846-51.
2007 Highly Cited Article	The 2007 Most Highly Cited Article of Amercan Chemical Society Journals Metabolism of Benzo[a]pyrene in Human Bronchoalveolar H358 Cells Using Liquid Chromatography-mass Spectrometry. Jiang H, Gelhaus SL, Mangal D, Harvey RG, Blair IA, Penning TM. Chem Res Toxicol. 2007 Sep;20(9):1331-41. Epub 2007 Aug 17. PMID: 17702526
	San Francisco/Oakland Bay Bridge Welder Study: Olfactory function (pdf) Marcelo B. Antunes, Rosemarie Bowler and Richard L. Doty. Neurology 2007;69;1278-1284
	BEYOND THE BENCH Research Helps Clean Up A Water Supply NIEHS Environmental Health Perspectives (pdf) VOLUME 115 \| NUMBER 3 \| March 2007 Dr. Ted Emmett, Director of the CEET Community Outreach and Education Core, is featured for his work with the Little Hocking community and the problem of perfluorooctanoic acid in their water supply.
	A 2006 Most-Cited Article of American Chemical Society Journals Competing Roles of Aldo-Keto Reductase 1A1 and Cytochrome P4501B1 in Benzo[a]pyrene-7,8-diol Activation in Human Bronchoalveolar H358 Cells: Role of AKRs in P4501B1 Induction (pdf) Hao Jiang, Daljit K. Vudathala, Ian A. Blair, and Trevor M. Penning Chemical Research in Toxicology. 19:1. (2006), 68-78.
	Population-Based Study of Natural Variation in the Melanocortin-1 Receptor Gene and Melanoma (pdf) Peter A. Kanetsky, Timothy R. Rebbeck, Amanda J. Hummer, Saarene Panossian,Bruce K. Armstrong, Anne Kricker, Loraine D. Marrett, Robert C. Millikan, Stephen B. Gruber, Hoda Anton Culver, Roberto Zanetti, Richard P. Gallagher, Terence Dwyer, Klaus Busam, Lynn From, Urvi Mujumdar, Homer Wilcox, Colin B. Begg, and Marianne Berwick, for the Genes Environment and Melanoma Study Group Cancer Res 2006; 66: (18). September 15, 2006: 9330–9337.
	Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry (pdf) Qian Ruan, Hye-Young H. Kim, Hao Jiang, Trevor M. Penning, Ronald G. Harvey and Ian A. Blair Rapid Commun. Mass Spectrom. 20 (2006): 1369–1380.
	Proteomic Profiling of Accessory Structures from the Mouse Sperm Flagellum (pdf) Wenlei Cao, George L. Gerton, and Stuart B. Moss Molecular & Cellular Proteomics. 5.5 (2006), 801-810.
	Reactive Oxygen Species Generated by PAH o-Quinones Cause Change-In-Function Mutations in p53 (pdf) Yu, Deshan, Jesse A. Berlin, Trevor M. Penning, and Jeffrey Field Chemical Research in Toxicology. 15:6 (June, 2002), 832-842.
	Role of Quinones in Toxicology (pdf) Bolton, Judy L., Michael A. Trush, Trevor M. Penning, Glenn Dryhurst, and Terrence J. Monks Chemical Research in Toxicology. 13:3 (March, 2000), 135-160.
1999 Highly Cited Article	A Highly Cited Paper of American Chemical Society Journals Dihydrodiol Dehydrogenases and Polycyclic Aromatic Hydrocarbon Activation: Generation of Reactive and Redox Active o -Quinones Penning, T. M.; Burczynski, M. E.; Hung, C.-F.; McCoull, K. D.; Palackal, N. T.; Tsuruda, L. S. Chem. Res. Toxicol.; (Review); 1999; 12(1); 1-18.
	Citation Classic: A New Nomenclature for the Aldo-Keto Reductase Superfamily (pdf) Joseph M. Jez, T. Geoffrey Flynn, and Trevor M. Penning Biochemical Pharmacology. 54 (1997), 639-647.

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