Newsworthy Items
Public Interest
The Lung Cancer Enablers
Jong-Heum Park et al. illuminate one of the three pathways by which polycyclic aromatic hydrocarbons (PAHs) can be activated, showing for the first time the specific pathway for oxidative damage in human lung cell.
Evidence for the Aldo-Keto Reductase Pathway of Polycyclic Aromatic Trans-dihydrodiol Activation in Human Lung A549 Cells. Park JH, Mangal D, Tacka KA, Quinn AM, Harvey RG, Blair IA, Penning TM. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6846-51.
Tracking The Chemicals In Us: Monitoring trace chemicals in people has benefited public health, but many challenges lie ahead
LARGE-SCALE MEASUREMENTS of chemicals in human tissues, or biomonitoring, is only about two decades old. But it has already led to a revolution in how chemical exposures are assessed in humans, to new opportunities in disease detection and prevention, and to a recognition that endocrine disrupters—compounds that mimic hormones or interfere with hormonal action—in the environment may cause a variety of adverse effects.
By
Bette Hileman
Chemical and Engineering News, April 23, 2007, Volume 85, Number 17, pp 32-34.
Hazardous Waste: Facilities have been unequally sited in poor, minority communities
University of Michigan researchers now think they have answered a long-standing chicken-and-egg question: Which came first, the hazardous waste facility or the poor, minority community surrounding it?
By Lois Ember
Chemical and Engineering News,
February 26, 2007,
Volume 85, Number 09,
p. 13
Governor Rendell Announces $17 Million Investment to Promote Health Research
The University of Pennsylvania – in association with the Pennsylvania State University Medical College and Lincoln University – will receive $4.2 million to study gene-environment interactions that increase the risk of lung cancer in African American and Caucasian smokers and non-smokers. The study will be conducted under the Gene-Environmental Initiative of the Center of Excellence in Environmental Toxicology, or CEET.
The Asbestos Disease Awareness Organization's Third Annual Asbestos Awareness Day Conference, Global Mission: Call To Action To Prevent, Detect, Treat Asbestos-Related Diseases & Trauma, will be held on March 31st at the Drexel University College of Medicine, 245 North 15th Street, in Philadelphia, Pennsylvania. CEET Investigator, Anil Vachani, M.D. will be a key speaker at the conference.
Drs. Penning and Emmett attend the NIEHS Center Directors Meeting in Galveston, TX
Focus is on Respiratory Disease and Cancer.
Asthma can be aggravated by urban living conditions
By Dr. Andrea Apter, CEET Investigator
The Philadelphia Tribune, October 15, 2006
Fish kill prompts warning about Schuylkill
People are told not to swim in or eat from the Schuylkill or Wissahickon
Philadelphia Inquirer, June 16, 2006
NIH Awards $4 Million to the University of Pennsylvania School of Medicine to
Establish a Center of Excellence in Environmental Toxicology
First Environmental Health Sciences Center in the Commonwealth
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Feature Publications
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Park JH, Gelhaus S, Vedantam S, Oliva AL, Batra A, Blair IA, Troxel AB, Field J, Penning TM. The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance. Chem Res Toxicol. 2008 May;21(5):1039-49. |
| Evidence for the Aldo-Keto Reductase Pathway of Polycyclic Aromatic Trans-dihydrodiol Activation in Human Lung A549 Cells. Park JH, Mangal D, Tacka KA, Quinn AM, Harvey RG, Blair IA, Penning TM. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6846-51. |
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** A Highly Cited Paper of American Chemical Society Journals** Dihydrodiol Dehydrogenases and Polycyclic Aromatic Hydrocarbon Activation: Generation of Reactive and Redox Active o -Quinones |
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** The 2007 Most Highly Cited Article of Amercan Chemical Society Journals** Metabolism of Benzo[a]pyrene in Human Bronchoalveolar H358 Cells Using Liquid Chromatography-mass Spectrometry. Jiang H, Gelhaus SL, Mangal D, Harvey RG, Blair IA, Penning TM. Chem Res Toxicol. 2007 Sep;20(9):1331-41. Epub 2007 Aug 17. PMID: 17702526 |
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San Francisco/Oakland Bay Bridge Welder Study: Olfactory function (pdf) Marcelo B. Antunes, Rosemarie Bowler and Richard L. Doty. Neurology 2007;69;1278-1284 |
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BEYOND THE BENCH |
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** A 2006 Most-Cited Article of American Chemical Society Journals ** Competing Roles of Aldo-Keto Reductase 1A1 and Cytochrome P4501B1 in Benzo[a]pyrene-7,8-diol Activation in Human Bronchoalveolar H358 Cells: Role of AKRs in P4501B1 Induction (pdf) |
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Population-Based Study of Natural Variation in the Melanocortin-1 Receptor Gene and Melanoma (pdf) Peter A. Kanetsky, Timothy R. Rebbeck, Amanda J. Hummer, Saarene Panossian,Bruce K. Armstrong, Anne Kricker, Loraine D. Marrett, Robert C. Millikan, Stephen B. Gruber, Hoda Anton Culver, Roberto Zanetti, Richard P. Gallagher, Terence Dwyer, Klaus Busam, Lynn From, Urvi Mujumdar, Homer Wilcox, Colin B. Begg, and Marianne Berwick, for the Genes Environment and Melanoma Study Group Cancer Res 2006; 66: (18). September 15, 2006: 9330–9337. |
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Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry (pdf) |
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Proteomic Profiling of Accessory Structures from the Mouse Sperm Flagellum (pdf) Wenlei Cao, George L. Gerton, and Stuart B. Moss Molecular & Cellular Proteomics. 5.5 (2006), 801-810. |
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Citation Classic: A New Nomenclature for the Aldo-Keto Reductase Superfamily (pdf) |
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Reactive Oxygen Species Generated by PAH o-Quinones Cause Change-In-Function Mutations in p53 (pdf) Yu, Deshan, Jesse A. Berlin, Trevor M. Penning, and Jeffrey Field Chemical Research in Toxicology. 15:6 (June, 2002), 832-842. |
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Role of Quinones in Toxicology (pdf) Bolton, Judy L., Michael A. Trush, Trevor M. Penning, Glenn Dryhurst, and Terrence J. Monks Chemical Research in Toxicology. 13:3 (March, 2000), 135-160. |
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