Prevention

Personalized Approach to Nicotine Addiction Treatment vs. Standard of Care

This pilot project investigates the comparative effectiveness of personalized approaches to nicotine addiction to the current, non-tailed approach to treatment. Cigarette smoking causes 80-90% of all lung cancer deaths, and increases the risk of several other cancers. Effective strategies for smoking cessation are a critically important goal for cancer prevention. We propose to test the efficacy of a clinical decision support tool built into an electronic medical record that will prompt the physician to ask a series of questions of a nicotine dependent patient interested in quitting and provide a treatment plan tailored to that individual patient's responses. We will also collect urine samples on a subset of the participant population to determine nicotine metabolism using a genetic marker to correlate results of the decision support tool with a biochemical marker of nicotine dependence. Active smokers interested in quitting will be eligible for this study. Personalized treatment options, including FDA approved medication and nicotine replacement, determined as appropriate by the physician will be offered to patients.