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Penn Center for AIDS Research

Penn CFAR HIV Virology/Pathogenesis- CURE Journal Club

The Viral/Molecular Core would like to open its bi-weekly Virology/Pathogenesis Journal Club to any CFAR member trainee (student, postdoc) who would like to participate. It’s held every other Thursday at 1:30 p.m. in 501 Johnson Pavilion. We have been having this for a while, and would like to expand it to others who are interested.

HIV Virology/Pathogenesis Journal Club Schedule:

Presentation Date Presenter Paper
6/16/16 Son Nguyen

Nat Med. 2016 May 30. doi: 10.1038/nm.4113. [Epub ahead of print]. PD-1+ and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals. Banga R1, Procopio FA1, Noto A1, Pollakis G2, Cavassini M3, Ohmiti K1, Corpataux JM4, de Leval L5, Pantaleo G1,6, Perreau M1. PMID:27239760.

6/2/16 Colby Maldini

Nature Microbiology 1, Article number: 16011 (2016) Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells. Gianluigi Lichinchi, Shang Gao, Yogesh Saletore, Gwendolyn Michelle Gonzalez, Vikas Bansal, Yinsheng Wang, Christopher E. Mason & Tariq M. Rana

5/19/16 Pia Dosenovic

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice. Dosenovic P, von Boehmer L, Escolano A, Jardine J, Freund NT, Gitlin AD, McGuire AT, Kulp DW, Oliveira T, Scharf L, Pietzsch J, Gray MD, Cupo A, van Gils MJ, Yao KH, Liu C, Gazumyan A, Seaman MS, Björkman PJ, Sanders RW, Moore JP, Stamatatos L, Schief WR, Nussenzweig MC. Cell. 2015 Jun 18;161(7):1505-15. doi: 10.1016/j.cell.2015.06.003. PMID: 26091035

5/5/16

Chris Chung

Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells. Sung JA, Pickeral J, Liu L, Stanfield-Oakley SA, Lam CY, Garrido C, Pollara J, LaBranche C, Bonsignori M, Moody MA, Yang Y, Parks R, Archin N, Allard B,Kirchherr J, Kuruc JD, Gay CL, Cohen MS, Ochsenbauer C, Soderberg K, Liao HX, Montefiori D, Moore P, Johnson S, Koenig S, Haynes BF, Nordstrom JL,Margolis DM, Ferrari G. PMID: 26413868

4/21/16 Shilpa Iyer

Nature. 2015 Oct 8;526(7572):218-23. doi: 10.1038/nature15400. Epub 2015 Sep 30.SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef. Usami Y1, Wu Y1, Göttlinger HG1. PMID: 26416733

4/7/16 Ronnie Russell

HIV-1 evades innate immune recognition through specific cofactor recruitment. Rasaiyaah J1, Tan CP, Fletcher AJ, Price AJ, Blondeau C, Hilditch L, Jacques DA, Selwood DL, James LC, Noursadeghi M, Towers GJ. PMID: 24196705

3/10/16

Christopher Chung

Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection. Sewald X1, Ladinsky MS2, Uchil PD3, Beloor J4, Pi R3, Herrmann C3, Motamedi N5, Murooka TT6, Brehm MA7, Greiner DL7, Shultz LD8, Mempel TR6, Bjorkman PJ2, Kumar P9, Mothes W1. PMID: 26429886

3/3/16 Ronnie Russell

Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.Matheson NJ1, Sumner J2, Wals K3, Rapiteanu R3, Weekes MP3, Vigan R2, Weinelt J2, Schindler M4, Antrobus R3, Costa AS5, Frezza C5, Clish CB6, Neil SJ2,Lehner PJ7.PMID: 26439863

2/11/16

Colby Maldini

Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions. Schultz BT1, Teigler JE2, Pissani F2, Oster AF2, Kranias G2, Alter G3, Marovich M2, Eller MA2, Dittmer U4, Robb ML2, Kim JH5, Michael NL6, Bolton D2, Streeck H7.PMID: 26795249

1/28/16 Son Nguyen

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection. Lynch RM1, Boritz E1, Coates EE1, DeZure A1, Madden P1, Costner P1, Enama ME1, Plummer S1, Holman L1, Hendel CS1, Gordon I1, Casazza J1, Conan-Cibotti M1, Migueles SA2, Tressler R3, Bailer RT1, McDermott A1, Narpala S1, O'Dell S1, Wolf G1, Lifson JD4, Freemire BA4, Gorelick RJ4, Pandey JP5, Mohan S5, Chomont N6, Fromentin R6, Chun TW2, Fauci AS2, Schwartz RM1, Koup RA1, Douek DC1, Hu Z7, Capparelli E8, Graham BS1, Mascola JR9, Ledgerwood JE9; VRC 601 Study Team. Sci Translational Med. 2015. PMID: 26702094

1/14/16 Brenda Salantes

Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. Ndhlovu ZM1, Kamya P1, Mewalal N2, Kløverpris HN3, Nkosi T2, Pretorius K2, Laher F2, Ogunshola F2, Chopera D4, Shekhar K5, Ghebremichael M6, Ismail N2, Moodley A1, Malik A7, Leslie A8, Goulder PJ9, Buus S10, Chakraborty A11, Dong K6, Ndung'u T12, Walker BD13. Immunity Sept. 2015. PMID: 26362266

12/17/15 Katie Wetzel

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques. Micci L, Ryan ES, Fromentin R, Bosinger SE, Harper JL, He T, Paganini S, Easley KA, Chahroudi A, Benne C, Gumber S, McGary CS, Rogers KA, Deleage C, Lucero C, Byrareddy SN, Apetrei C, Estes JD, Lifson JD, Piatak M Jr, Chomont N, Villinger F, Silvestri G, Brenchley JM, Paiardini M. J Clin Invest. 2015 Dec 1. PMID: 26551680

12/3/15 Kitu Kumar

Targeting HIV Reservoir in Infected CD4 T Cells by Dual-Affinity Re-targeting Molecules (DARTs) that Bind HIV Envelope and Recruit Cytotoxic T Cells. PLoS Pathogens. 2015 Nov 5. Derek D. Sloan , Chia-Ying Kao Lam, Alivelu Irrinki, Liqin Liu, Angela Tsai, Craig S. Pace, Jasmine Kaur, Jeffrey P. Murry, Mini Balakrishnan, Paul A. Moore, Syd Johnson, Jeffrey L. Nordstrom, Tomas Cihlar, Scott Koenig. PMID: 26539983

11/19/15 Samra Elser

Heterosexual Transmission of Subtype C HIV-1 Selects Consensus-Like Variants without Increased Replicative Capacity or Interferon-α Resistance. PLoS Pathogens. 2015 Sept 17. Martin J. Deymier1, Zachary Ende1, Angharad E. Fenton-May2, Dario A. Dilernia1, William Kilembe3, Susan A. Allen4, Persephone Borrow2, Eric Hunter1,4. PMID: 26378795

11/5/15 Jean Scholz

Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies. Science. 2015 Aug 14. Williams WB, Liao HX, Moody MA, Kepler TB, Alam SM, Gao F, Wiehe K, Trama AM, Jones K, Zhang R, Song H, Marshall DJ, Whitesides JF, Sawatzki K, Hua A, Liu P, Tay MZ, Seaton KE, Shen X, Foulger A, Lloyd KE, Parks R, Pollara J, Ferrari G, Yu JS, Vandergrift N, Montefiori DC, Sobieszczyk ME, Hammer S, Karuna S, Gilbert P, Grove D, Grunenberg N, McElrath MJ, Mascola JR, Koup RA, Corey L, Nabel GJ, Morgan C, Churchyard G, Maenza J, Keefer M, Graham BS, Baden LR, Tomaras GD, Haynes BF.PMID: 26229114

10/8/15

Kristel Emmer

Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals. PNAS. 2014 Sept. Hu H, Eller MA, Zafar S, Zhou Y, Gu M, Wei Z, Currier JR, Marovich MA, Kibuuka HN, Bailer RT, Koup RA, Robb ML, Michael NL, Kim JH, Ratto-Kim S. PubMed PMID: 25197078; PubMed Central PMCID: PMC4169982

9/10/2015 Rachel Liebman

HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition. Prentice HA1, Tomaras GD2, Geraghty DE3, Apps R4, Fong Y5, Ehrenberg PK6, Rolland M1, Kijak GH1, Krebs SJ1, Nelson W3, DeCamp A5, Shen X2, Yates NL2, Zolla-Pazner S7, Nitayaphan S8, Rerks-Ngarm S9, Kaewkungwal J10, Pitisuttithum P11, Ferrari G2, McElrath MJ5, Montefiori DC2, Bailer RT12, Koup RA12, O'Connell RJ8, Robb ML1, Michael NL6, Gilbert PB5, Kim JH6, Thomas R13. PMID: 26180102

8/27/2015 Costin Tomescu

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques. Mothe B1,2,3, Hu X4, Llano A5, Rosati M6, Olvera A7, Kulkarni V8, Valentin A9, Alicea C10, Pilkington GR11, Sardesai NY12, Rocafort M13, Crespo M14, Carrillo J15, Marco A16, Mullins JI17, Dorrell L18, Hanke T19, Clotet B20,21,22,23, Pavlakis GN24, Felber BK25, Brander C26,27,28,29. PMID: 25879820

8/13/2015 Katie Wetzel

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys. Barouch et al, Science Jul 2015. PMID: 26138104

7/30/2015 Mike Hogan

HIV-1 neutralizing antibodies induced by native-like envelope trimers. Sanders RW1, van Gils MJ2, Derking R2, Sok D3, Ketas TJ4, Burger JA2, Ozorowski G5, Cupo A4, Simonich C6, Goo L6, Arendt H7, Kim HJ5, Lee JH5, Pugach P4, Williams M4, Debnath G4, Moldt B3, van Breemen MJ2, Isik G2, Medina-Ramírez M2, Back JW8, Koff WC7, Julien JP5, Rakasz EG9, Seaman MS10, Guttman M11, Lee KK11, Klasse PJ4, LaBranche C12, Schief WR13, Wilson IA14, Overbaugh J6, Burton DR15, Ward AB5, Montefiori DC12, Dean H7, Moore JP16. PMID: 26089353

7/16/2015 Brenda Salantes

Cervicovaginal Bacteria Are a Major Modulator of Host Inflammatory Responses in the Female Genital Tract Melis N. Anahtar, Elizabeth H. Byrne, Kathleen E. Doherty, Brittany A. Bowman, Hidemi S. Yamamoto, Magali Soumillon, Nikita Padavattan, Nasreen Ismail, Amber Moodley, Mary E. Sabatini, Musie S. Ghebremichael, Chad Nusbaum, Curtis Huttenhower, Herbert W. Virgin, Thumbi Ndung’u, Krista L. Dong, Bruce D. Walker, Raina N. Fichorova, and Douglas S. Kwon PMID: 25992865

7/2/2015 Ronnie Russell

Differential regulation of NF-κB-mediated proviral and antiviral host gene expression by primate lentiviral Nef and Vpu proteins. Sauter D1, Hotter D2, Van Driessche B3, Stürzel CM2, Kluge SF2, Wildum S2, Yu H2, Baumann B4, Wirth T4, Plantier JC5, Leoz M5, Hahn BH6, Van Lint C3, Kirchhoff F7. PMID: 25620704

6/17/2015 Kitu Kumar

Effects of the I559P gp41 change on the conformation and function of the human immunodeficiency virus (HIV-1) membrane envelope glycoprotein trimer. Alsahafi N1, Debbeche O2, Sodroski J3, Finzi A4. PMID: 25849367

6/4/2015 George Leslie

CD4 mimetics sensitize HIV-1-infected cells to ADCC. Richard J1, Veillette M1, Brassard N2, Iyer SS3, Roger M1, Martin L4, Pazgier M5, Schön A6, Freire E6, Routy JP7, Smith AB 3rd8, Park J8, Jones DM8, Courter JR8, Melillo BN8, Kaufmann DE9, Hahn BH10, Permar SR11, Haynes BF11, Madani N12, Sodroski JG12, Finzi A13. PMID: 25941367

5/21/2015 Son Nguyen

HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4 T Lymphocytes, Lia Vassena, Erica Giuliani, Herwig Koppensteiner, Sebastian Bolduan, Michael Schindler, Margherita Doria PMID: 25822027

5/7/2015 Melanie Duncan

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 Caskey et al. 2015

4/23/2015 Jean L. Scholz Intra-Spike Crosslinking Overcomes Antibody Evasion by HIV-1. Galimidi RP et al. Cell 2015 PMID: 25635457
4/9/2015 Katie Wetzel AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges. Gardner et al. Nature PMID: 2015 25707797
3/12/2015 Brenda Salantes B cell follicle sanctuary permits persistent productive simian immunodeficiency virus in elite controllers, Nat Med 2015
2/12/2015 Rachel Liebman Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Deng et al., Nature 2015
1/29/2015 Mike Hogan Tetherin Can Restrict Cell-Free and Cell-Cell Transmission of HIV from Primary Macrophages to T Cells, PLOS 2014
1/15/2015 Brenda Salantes Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Barouch et al, Nature 2013
12/6/2014 Katie Wetzel Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells. Calantone et al, Immunity 2014.
11/20/2014 Ted Krieder Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Pancera et al, Nature 2014
10/23/2014 Melanie Duncan HIV-1-induced AIDS in monkeys. Hatziioannou et al, Science 2014
10/9/2014 Dino Romero RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. Hu et al, PNAS 2014
9/25/2014 Adrienne Swanstrom Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression. Sandler, et al. Nature 2014
9/11/2014 Kitu Kumar Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. Tebas et al. N Engl J Med. 2014
8/28/2014 Mike Hogan Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study. Saez-Ciron et al, PLOS Path 2014.
7/31/2014 Samra Elser The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time. Josefsson et al. PNAS 2013
7/17/2014 Katie Wetzel Proliferation of cells with HIV integrated into cancer genes
contributes to persistent infection Wagner et al, Science 2014.
6/19/2014 Alex Gill Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication. Kristoff et al, JCI 2014.
6/5/2014 Sarah Elliott Boosting of HIV-1 Neutralizing Antibody Responses by a Distally Related Retroviral Envelope Protein. Uchtenhagen et al, JI 2014
5/22/2014 Dino Romero Long-Acting Integrase Inhibitor Protects Macaques from Intrarectal Simian/Human Immunodeficiency Virus. Andrews et al, Science 2014
5/8/2014 Adrienne Swanstrom Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines. Fukazawa et al. Nat Med 2012
4/24/2014 Melanie Duncan Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues. Fletcher et al PNAS 2013
4/10/2014 Katie Wetzel Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure. Ho et al, Cell 2013
3/27/2014 Sarah Gwyn HIV-1 persistence in CD4+ T cells with stem celllike properties. Buzon et al. Nat Med 2013
2/27/2014 Mike Hogan SAMHD1 restricts HIV-1 infection in resting CD4+ T cells. Baldauf et al Nat Med 2012
2/20/2014 Sarah Gwyn Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Dotish et al, Nature 2014