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Penn Center for AIDS Research

Penn CFAR HIV Virology/Pathogenesis- CURE Journal Club

The Viral/Molecular Core would like to open its bi-weekly Virology/Pathogenesis Journal Club to any CFAR member trainee (student, postdoc) who would like to participate. It’s held every other Thursday at 1:30 p.m. in 501 Johnson Pavilion. If you would like to present a paper in the future, please send an email to grant.eilers@uphs.upenn.edu. Any HIV-related topic is welcome!

HIV Virology/Pathogenesis Journal Club Schedule:

Presentation Date Presenter Paper
2018    
6/14/2018 Ziyang Xu HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies
Steichen JM, Kulp DW, Tokatlian T, Escolano A, Dosenovic P, Stanfield RL,
McCoy LE, Ozorowski G, Hu X, Kalyuzhniy O, Briney B, Schiffner T, Garces F, Freund NT, Gitlin AD, Menis S, Georgeson E, Kubitz M, Adachi Y, Jones M, Mutafyan AA, Yun DS, Mayer CT, Ward AB, Burton DR, Wilson IA, Irvine DJ, Nussenzweig MC, Schief WR. Immunity. 2016 Sep 20;45(3):483-496. doi: 10.1016/j.immuni.2016.08.016. Epub 2016 Sep 8. PubMed PMID: 27617678; PubMed Central PMCID: PMC5040827
5/31/2018 Mary Margaret Addison Resistance of HIV-infected macrophages to CD8+ T lymphocyte–mediated killing drives activation of the immune system.
Clayton KL, Collins DR, Lengieza J, Ghebremichael M, Dotiwala F, Lieberman J, Walker BD. Nat Immunol. 2018
May;19(5):475-486. doi: 10.1038/s41590-018-0085-3. Epub 2018 Apr 18. PubMed PMID: 29670239
5/17/2018 Yanhui Cai Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses.
McNamara RP, Costantini LM, Myers TA, Schouest B, Maness NJ, Griffith JD, Damania BA, MacLean AG, Dittmer DP. MBio.
2018 Feb 6;9(1). pii: e02344-17. doi: 10.1128/mBio.02344-17. PubMed PMID: 29437924; PubMed Central PMCID: PMC5801467
5/3/2018 Analise Gruenewald Superinfection Drives HIV Neutralizing Antibody Responses from Several B Cell Lineages that Contribute to a Polyclonal Repertoire.
Williams KL, Wang B, Arenz D, Williams JA, Dingens AS, Cortez V, Simonich CA, Rainwater S, Lehman DA, Lee KK, Overbaugh J. Cell Rep. 2018 Apr 17;23(3):682-691. doi:10.1016/j.celrep.2018.03.082. PubMed PMID: 29669274
4/19/2018 Rebecca Nusbaum Exosomal miR-9 Released from HIV Tat Stimulated Astrocytes Mediates Microglial Migration.
Yang L, Niu F, Yao H, Liao K, Chen X, Kook Y, Ma R, Hu G, Buch S. J Neuroimmune Pharmacol. 2018 Mar 1. doi: 10.1007/s11481-018-9779-4. [Epub ahead of print] PubMed PMID: 29497921
4/5/2018 Grant Eilers Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host.
Palesch D, Bosinger SE, Tharp GK, Vanderford TH, Paiardini M, Chahroudi A, Johnson ZP, Kirchhoff F, Hahn BH, Norgren RB, Patel NB, Sodora DL, Dawoud RA, Stewart CB, Seepo SM, Harris RA, Liu Y, Raveendran M, Han Y, English A, Thomas GWC, Hahn MW, Pipes L, Mason CE, Muzny DM, Gibbs RA, Sauter D, Worley K, Rogers J, Silvestri G. Nature. 2018 Jan 3;553(7686):77-81. doi: 10.1038/nature25140. PubMed PMID: 29300007; PubMed Central PMCID: PMC5843367
3/22/2018 Krystal Colon-Rivera CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV-1 infection in macrophages.
Taylor JP, Cash MN, Santostefano KE, Nakanishi M, Terada N, Wallet MA. J Leukoc Biol. 2018 Feb 13. doi:
10.1002/JLB.3MIA0917-352R. [Epub ahead of print] PubMed PMID: 29437254
2017    
12/21/2017 Ziyang Xu Antibody 10-1074 suppresses viremia in HIV-1-infected individuals.
Caskey M, Schoofs T, Gruell H, Settler A, Karagounis T, Kreider EF, Murrell B, Pfeifer N, Nogueira L, Oliveira TY, Learn GH, Cohen YZ, Lehmann C, Gillor D, Shimeliovich I, Unson-O'Brien C, Weiland D, Robles A, Kümmerle T, Wyen C, Levin R, Witmer-Pack M, Eren K, Ignacio C, Kiss S, West AP Jr, Mouquet H, Zingman BS, Gulick RM, Keler T, Bjorkman PJ, Seaman MS, Hahn BH, Fätkenheuer G, Schlesinger SJ, Nussenzweig MC, Klein F.
Nat Med. 2017 Feb;23(2):185-191. doi: 10.1038/nm.4268. Epub 2017 Jan 16. PMID:28092665
12/7/2017 Anya Bauer Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART.
Wiegand A, Spindler J, Hong FF, Shao W, Cyktor JC, Cillo AR, Halvas EK, Coffin JM, Mellors JW, Kearney MF. Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3659-E3668. doi: 10.1073/pnas.1617961114. Epub 2017 Apr 17. PMID:28416661
11/9/2017

Mary Margaret Addison

 

Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor.
Lodge R, Ferreira Barbosa JA, Lombard-Vadnais F, Gilmore JC, Deshiere A, Gosselin A, Wiche Salinas TR, Bego MG, Power C, Routy JP, Ancuta P, Tremblay MJ, Cohen ÉA. Cell Rep. 2017 Oct 3;21(1):141-153. doi: 10.1016/j.celrep.2017.09.030. PMID:28978468.

10/26/2017 Anya Bauer Defining total-body AIDS-virus burden with implications for curative strategies.
Estes JD, Kityo C, Ssali F, Swainson L, Makamdop KN, Del Prete GQ, Deeks SG, Luciw PA, Chipman JG, Beilman GJ, Hoskuldsson T, Khoruts A, Anderson J, Deleage C, Jasurda J, Schmidt TE, Hafertepe M, Callisto SP, Pearson H, Reimann T, Schuster J, Schoephoerster J, Southern P, Perkey K, Shang L, Wietgrefe SW, Fletcher CV, Lifson JD, Douek DC, McCune JM, Haase AT, Schacker TW. Nat Med. 2017 Nov;23(11):1271-1276. doi: 10.1038/nm.4411. Epub 2017 Oct 2. PMID:28967921
10/12/2017 Ziyang Xu Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows.
1: Sok D, Le KM, Vadnais M, Saye-Francisco KL, Jardine JG, Torres JL, Berndsen ZT, Kong L, Stanfield R, Ruiz J, Ramos A, Liang CH, Chen PL, Criscitiello MF, Mwangi W, Wilson IA, Ward AB, Smider VV, Burton DR.
Nature. 2017 Aug3; 548(7665):108-111. doi: 10.1038/nature23301. Epub 2017 Jul 20. PubMed PMID: 28726771.
9/28/2017 Ryan Roark Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo.
1: Horwitz JA, Bar-On Y, Lu CL, Fera D, Lockhart AAK, Lorenzi JCC, Nogueira L, Golijanin J, Scheid JF, Seaman MS, Gazumyan A, Zolla-Pazner S, Nussenzweig MC. Cell. 2017 Aug 10;170(4):637-648.e10. doi: 10.1016/j.cell.2017.06.048. Epub 2017 Jul 27. PubMed PMID: 28757252; PubMed Central PMCID: PMC5554461.

9/14/2017

Grant Eilers Functional Segregation of Overlapping Genes in HIV.
1: Fernandes JD, Faust TB, Strauli NB, Smith C, Crosby DC, Nakamura RL, Hernandez RD, Frankel AD. Cell. 2016 Dec 15;167(7):1762-1773.e12. doi: 10.1016/j.cell.2016.11.031. PubMed PMID: 27984726; PubMed Central PMCID: PMC5287106.
8/31/2017

Mary Addison

Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets.
1: Ribeiro CM, Sarrami-Forooshani R, Setiawan LC, Zijlstra-Willems EM, van Hamme JL, Tigchelaar W, van der Wel NN, Kootstra NA, Gringhuis SI, Geijtenbeek TB.Nature. 2016 Dec 15;540(7633):448-452. doi: 10.1038/nature20567. Epub 2016 Dec 7. PubMed PMID: 27919079.
8/17/2017 Brenda Salantes Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women.
1: Klatt NR, Cheu R, Birse K, Zevin AS, Perner M, Noël-Romas L, Grobler A,
Westmacott G, Xie IY, Butler J, Mansoor L, McKinnon LR, Passmore JS, Abdool Karim Q, Abdool Karim SS, Burgener AD. Science. 2017 Jun 2;356(6341):938-945. doi: 10.1126/science.aai9383. PubMed PMID: 28572388.
8/3/2017 Analise Gruenewald Astrocytes Resist HIV-1 Fusion but Engulf Infected Macrophage Material.
1: Russell RA, Chojnacki J, Jones DM, Johnson E, Do T, Eggeling C, Padilla-Parra S, Sattentau QJ. Cell Rep. 2017 Feb 7;18(6):1473-1483. doi:
10.1016/j.celrep.2017.01.027. PubMed PMID: 28178524; PubMed Central PMCID: PMC5316642.
7/20/2017 Michael Hogan Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.
1: Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT.
Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2729-2734. doi: 10.1073/pnas.1613635114. Epub 2017 Feb 22. PubMed PMID: 28228523; PubMed Central PMCID: PMC5347584.
7/6/2017 Yanhui Cai CD4+ T-cell-independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection.
1: Foreman TW, Mehra S, LoBato DN, Malek A, Alvarez X, Golden NA, Bucşan AN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Roy CJ, Blanchard J, Kuroda MJ, Lackner AA, Chan J, Khader SA, Jacobs WR Jr, Kaushal D. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5636-44. doi:
10.1073/pnas.1611987113. Epub 2016 Sep 6. PubMed PMID: 27601645; PubMed Central PMCID: PMC5035858.
6/22/2017 Natania Field Targeting type I interferon-mediated activation restores immune function in chronic HIV infection.
Zhen A, Rezek V, Youn C, Lam B, Chang N, Rick J, Carrillo M, Martin H,
Kasparian S, Syed P, Rice N, Brooks DG, Kitchen SG. J Clin Invest. 2017 Jan 3;127(1):260-268. doi: 10.1172/JCI89488. Epub 2016 Dec
12. PubMed PMID: 27941243; PubMed Central PMCID: PMC5199686.
6/8/2017 Grant Eiler A supramolecular assembly mediates lentiviral DNA integration.
Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jónsson SR,
Kotecha A, Cook NJ, Pye VE, Taylor IA, Andrésdóttir V, Engelman AN, Costa A, Cherepanov P. Science. 2017 Jan 6;355(6320):93-95. doi: 10.1126/science.aah7002. PubMed PMID: 28059770
5/27/2017 Ryan Roark Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing.
Christina Guzzo1,*, David Ichikawa1,*, Chung Park2, Damilola Phillips1, Qingbo Liu1, Peng Zhang1, Alice Kwon1, Huiyi Miao1, Jacky Lu1, Catherine Rehm3, James Arthos4, Claudia Cicala4, Myron S. Cohen5, Anthony S. Fauci4, John H. Kehrl2 and Paolo Lusso1,† Science Immunology 12 May 2017: Vol. 2, Issue 11, eaam7341 DOI: 10.1126/sciimmunol.aam7341
4/27/2017 Anya Bauer CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses.
Descours B, Petitjean G, López-Zaragoza JL, Bruel T, Raffel R, Psomas C,
Reynes J, Lacabaratz C, Levy Y, Schwartz O, Lelievre JD, Benkirane M.
Nature. 2017 Mar 23;543(7646):564-567. doi: 10.1038/nature21710. Epub 2017 Mar 15. PubMed PMID: 28297712
4/13/2017 Krystal Colon-Rivera Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs.
Gnanadhas DP, Dash PK, Sillman B, Bade AN, Lin Z, Palandri DL, Gautam N, Alnouti Y, Gelbard HA, McMillan J, Mosley RL, Edagwa B, Gendelman HE, Gorantla S. J Clin Invest. 2017 Mar 1;127(3):857-873. doi:
10.1172/JCI90025. Epub 2017 Jan 30. PubMed PMID: 28134625
3/30/2017 Brenda Salantes Social status alters immune regulation and response to infection in macaques.
Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S, Shaver AO, Grenier JC, Pique-Regi R, Johnson ZP, Wilson ME, Barreiro LB, Tung J. Science. 2016 Nov 25;354(6315):1041-1045. PubMed PMID: 27885030.
3/16/2017 Katie Wetzel Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.
Muenchhoff M, Adland E, Karimanzira O, Crowther C, Pace M, Csala A, Leitman E, Moonsamy A, McGregor C, Hurst J, Groll A, Mori M, Sinmyee S, Thobakgale C, Tudor-Williams G, Prendergast AJ, Kloverpris H, Roider J, Leslie A, Shingadia D, Brits T, Daniels S, Frater J, Willberg CB, Walker BD, Ndung'u T, Jooste P, Moore PL, Morris L, Goulder P. Sci Transl Med. 2016 Sep 28;8(358):358ra125. doi: 10.1126/scitranslmed.aag1048.
PubMed PMID: 27683550.
3/2/2017 Ryan Roark Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies. McCoy LE, van Gils MJ, Ozorowski G, Messmer T, Briney B, Voss JE, Kulp DW, Macauley MS, Sok D, Pauthner M, Menis S, Cottrell CA, Torres JL, Hsueh J, Schief WR, Wilson IA, Ward AB, Sanders RW, Burton DR. Cell Rep. 2016 Aug 30;16(9):2327-38. doi: 10.1016/j.celrep.2016.07.074. Epub 2016 Aug 18. PubMed PMID: 27545891; PubMed Central PMCID: PMC5007210.
2/16/2017 Anya Bauer A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges.
Gautam R, Nishimura Y, Pegu A, Nason MC, Klein F, Gazumyan A, Golijanin J, Buckler-White A, Sadjadpour R, Wang K, Mankoff Z, Schmidt SD, Lifson JD, Mascola JR, Nussenzweig MC, Martin MA. Nature. 2016 May 5;533(7601):105-9. doi: 10.1038/nature17677. Epub 2016 Apr 27. PubMed PMID: 27120156; PubMed Central PMCID: PMC5127204.
2/2/2017 Ryan Roark Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.
Freund NT, Wang H, Scharf L, Nogueira L, Horwitz JA, Bar-On Y, Golijanin J, Sievers SA, Sok D, Cai H, Cesar Lorenzi JC, Halper-Stromberg A, Toth I, Piechocka-Trocha A, Gristick HB, van Gils MJ, Sanders RW, Wang LX, Seaman MS, Burton DR, Gazumyan A, Walker BD, West AP Jr, Bjorkman PJ, Nussenzweig MC. Sci Transl Med. 2017 Jan 18;9(373). pii: eaal2144. doi: 10.1126/scitranslmed.aal2144. PMID: 28100831
2016    
12/15/2016 Natania Field Macrophages sustain HIV replication in vivo independently of T cells. Honeycutt JB, Wahl A, Baker C, Spagnuolo RA, Foster J, Zakharova O, Wietgrefe S, Caro-Vegas C, Madden V, Sharpe G, Haase AT, Eron JJ, Garcia JV. J Clin Invest. 2016 Apr 1;126(4):1353-66. doi: 10.1172/JCI84456. PMID: 26950420
12/1/2016 Mary Margaret Addison HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4 T Cells.
Vermeire J, Roesch F, Sauter D, Rua R, Hotter D, Van Nuffel A, Vanderstraeten H, Naessens E, Iannucci V, Landi A, Witkowski W, Baeyens A, Kirchhoff F, Verhasselt B. Cell Rep. 2016 Oct 4;17(2):413-424. doi: 10.1016/j.celrep.2016.09.023. PMID: 27705790
11/17/2016 Ronnie Russell Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction. Foster TL, Wilson H, Iyer SS, Coss K, Doores K, Smith S, Kellam P, Finzi A, Borrow P, Hahn BH, Neil SJ. Cell Host Microbe. 2016 Oct 12;20(4):429-442. doi: 10.1016/j.chom.2016.08.006.
PMID: 27640936
10/20/2016 Son Nguyen Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.
Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA. Science. 2016 Oct 14;354(6309):197-202. PMID: 27738167
6/16/2016 Son Nguyen

Nat Med. 2016 May 30. doi: 10.1038/nm.4113. [Epub ahead of print]. PD-1+ and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals. Banga R1, Procopio FA1, Noto A1, Pollakis G2, Cavassini M3, Ohmiti K1, Corpataux JM4, de Leval L5, Pantaleo G1,6, Perreau M1. PMID:27239760.

6/2/2016 Colby Maldini

Nature Microbiology 1, Article number: 16011 (2016) Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells. Gianluigi Lichinchi, Shang Gao, Yogesh Saletore, Gwendolyn Michelle Gonzalez, Vikas Bansal, Yinsheng Wang, Christopher E. Mason & Tariq M. Rana

5/19/2016 Pia Dosenovic

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice. Dosenovic P, von Boehmer L, Escolano A, Jardine J, Freund NT, Gitlin AD, McGuire AT, Kulp DW, Oliveira T, Scharf L, Pietzsch J, Gray MD, Cupo A, van Gils MJ, Yao KH, Liu C, Gazumyan A, Seaman MS, Björkman PJ, Sanders RW, Moore JP, Stamatatos L, Schief WR, Nussenzweig MC. Cell. 2015 Jun 18;161(7):1505-15. doi: 10.1016/j.cell.2015.06.003. PMID: 26091035

5/5/2016

Chris Chung

Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells. Sung JA, Pickeral J, Liu L, Stanfield-Oakley SA, Lam CY, Garrido C, Pollara J, LaBranche C, Bonsignori M, Moody MA, Yang Y, Parks R, Archin N, Allard B,Kirchherr J, Kuruc JD, Gay CL, Cohen MS, Ochsenbauer C, Soderberg K, Liao HX, Montefiori D, Moore P, Johnson S, Koenig S, Haynes BF, Nordstrom JL,Margolis DM, Ferrari G. PMID: 26413868

4/21/2016 Shilpa Iyer

Nature. 2015 Oct 8;526(7572):218-23. doi: 10.1038/nature15400. Epub 2015 Sep 30.SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef. Usami Y1, Wu Y1, Göttlinger HG1. PMID: 26416733

4/7/2016 Ronnie Russell

HIV-1 evades innate immune recognition through specific cofactor recruitment. Rasaiyaah J1, Tan CP, Fletcher AJ, Price AJ, Blondeau C, Hilditch L, Jacques DA, Selwood DL, James LC, Noursadeghi M, Towers GJ. PMID: 24196705

3/10/2016

Christopher Chung

Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection. Sewald X1, Ladinsky MS2, Uchil PD3, Beloor J4, Pi R3, Herrmann C3, Motamedi N5, Murooka TT6, Brehm MA7, Greiner DL7, Shultz LD8, Mempel TR6, Bjorkman PJ2, Kumar P9, Mothes W1. PMID: 26429886

3/3/2016 Ronnie Russell

Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.Matheson NJ1, Sumner J2, Wals K3, Rapiteanu R3, Weekes MP3, Vigan R2, Weinelt J2, Schindler M4, Antrobus R3, Costa AS5, Frezza C5, Clish CB6, Neil SJ2,Lehner PJ7.PMID: 26439863

2/11/2016

Colby Maldini

Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions. Schultz BT1, Teigler JE2, Pissani F2, Oster AF2, Kranias G2, Alter G3, Marovich M2, Eller MA2, Dittmer U4, Robb ML2, Kim JH5, Michael NL6, Bolton D2, Streeck H7.PMID: 26795249

1/28/2016 Son Nguyen

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection. Lynch RM1, Boritz E1, Coates EE1, DeZure A1, Madden P1, Costner P1, Enama ME1, Plummer S1, Holman L1, Hendel CS1, Gordon I1, Casazza J1, Conan-Cibotti M1, Migueles SA2, Tressler R3, Bailer RT1, McDermott A1, Narpala S1, O'Dell S1, Wolf G1, Lifson JD4, Freemire BA4, Gorelick RJ4, Pandey JP5, Mohan S5, Chomont N6, Fromentin R6, Chun TW2, Fauci AS2, Schwartz RM1, Koup RA1, Douek DC1, Hu Z7, Capparelli E8, Graham BS1, Mascola JR9, Ledgerwood JE9; VRC 601 Study Team. Sci Translational Med. 2015. PMID: 26702094

1/14/2016 Brenda Salantes

Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. Ndhlovu ZM1, Kamya P1, Mewalal N2, Kløverpris HN3, Nkosi T2, Pretorius K2, Laher F2, Ogunshola F2, Chopera D4, Shekhar K5, Ghebremichael M6, Ismail N2, Moodley A1, Malik A7, Leslie A8, Goulder PJ9, Buus S10, Chakraborty A11, Dong K6, Ndung'u T12, Walker BD13. Immunity Sept. 2015. PMID: 26362266

2015    
12/17/2015 Katie Wetzel

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques. Micci L, Ryan ES, Fromentin R, Bosinger SE, Harper JL, He T, Paganini S, Easley KA, Chahroudi A, Benne C, Gumber S, McGary CS, Rogers KA, Deleage C, Lucero C, Byrareddy SN, Apetrei C, Estes JD, Lifson JD, Piatak M Jr, Chomont N, Villinger F, Silvestri G, Brenchley JM, Paiardini M. J Clin Invest. 2015 Dec 1. PMID: 26551680

12/3/2015 Kitu Kumar

Targeting HIV Reservoir in Infected CD4 T Cells by Dual-Affinity Re-targeting Molecules (DARTs) that Bind HIV Envelope and Recruit Cytotoxic T Cells. PLoS Pathogens. 2015 Nov 5. Derek D. Sloan , Chia-Ying Kao Lam, Alivelu Irrinki, Liqin Liu, Angela Tsai, Craig S. Pace, Jasmine Kaur, Jeffrey P. Murry, Mini Balakrishnan, Paul A. Moore, Syd Johnson, Jeffrey L. Nordstrom, Tomas Cihlar, Scott Koenig. PMID: 26539983

11/19/2015 Samra Elser

Heterosexual Transmission of Subtype C HIV-1 Selects Consensus-Like Variants without Increased Replicative Capacity or Interferon-α Resistance. PLoS Pathogens. 2015 Sept 17. Martin J. Deymier1, Zachary Ende1, Angharad E. Fenton-May2, Dario A. Dilernia1, William Kilembe3, Susan A. Allen4, Persephone Borrow2, Eric Hunter1,4. PMID: 26378795

11/5/2015 Jean Scholz

Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies. Science. 2015 Aug 14. Williams WB, Liao HX, Moody MA, Kepler TB, Alam SM, Gao F, Wiehe K, Trama AM, Jones K, Zhang R, Song H, Marshall DJ, Whitesides JF, Sawatzki K, Hua A, Liu P, Tay MZ, Seaton KE, Shen X, Foulger A, Lloyd KE, Parks R, Pollara J, Ferrari G, Yu JS, Vandergrift N, Montefiori DC, Sobieszczyk ME, Hammer S, Karuna S, Gilbert P, Grove D, Grunenberg N, McElrath MJ, Mascola JR, Koup RA, Corey L, Nabel GJ, Morgan C, Churchyard G, Maenza J, Keefer M, Graham BS, Baden LR, Tomaras GD, Haynes BF.PMID: 26229114

10/8/2015

Kristel Emmer

Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals. PNAS. 2014 Sept. Hu H, Eller MA, Zafar S, Zhou Y, Gu M, Wei Z, Currier JR, Marovich MA, Kibuuka HN, Bailer RT, Koup RA, Robb ML, Michael NL, Kim JH, Ratto-Kim S. PubMed PMID: 25197078; PubMed Central PMCID: PMC4169982

9/10/2015 Rachel Liebman

HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition. Prentice HA1, Tomaras GD2, Geraghty DE3, Apps R4, Fong Y5, Ehrenberg PK6, Rolland M1, Kijak GH1, Krebs SJ1, Nelson W3, DeCamp A5, Shen X2, Yates NL2, Zolla-Pazner S7, Nitayaphan S8, Rerks-Ngarm S9, Kaewkungwal J10, Pitisuttithum P11, Ferrari G2, McElrath MJ5, Montefiori DC2, Bailer RT12, Koup RA12, O'Connell RJ8, Robb ML1, Michael NL6, Gilbert PB5, Kim JH6, Thomas R13. PMID: 26180102

8/27/2015 Costin Tomescu

A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques. Mothe B1,2,3, Hu X4, Llano A5, Rosati M6, Olvera A7, Kulkarni V8, Valentin A9, Alicea C10, Pilkington GR11, Sardesai NY12, Rocafort M13, Crespo M14, Carrillo J15, Marco A16, Mullins JI17, Dorrell L18, Hanke T19, Clotet B20,21,22,23, Pavlakis GN24, Felber BK25, Brander C26,27,28,29. PMID: 25879820

8/13/2015 Katie Wetzel

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys. Barouch et al, Science Jul 2015. PMID: 26138104

7/30/2015 Mike Hogan

HIV-1 neutralizing antibodies induced by native-like envelope trimers. Sanders RW1, van Gils MJ2, Derking R2, Sok D3, Ketas TJ4, Burger JA2, Ozorowski G5, Cupo A4, Simonich C6, Goo L6, Arendt H7, Kim HJ5, Lee JH5, Pugach P4, Williams M4, Debnath G4, Moldt B3, van Breemen MJ2, Isik G2, Medina-Ramírez M2, Back JW8, Koff WC7, Julien JP5, Rakasz EG9, Seaman MS10, Guttman M11, Lee KK11, Klasse PJ4, LaBranche C12, Schief WR13, Wilson IA14, Overbaugh J6, Burton DR15, Ward AB5, Montefiori DC12, Dean H7, Moore JP16. PMID: 26089353

7/16/2015 Brenda Salantes

Cervicovaginal Bacteria Are a Major Modulator of Host Inflammatory Responses in the Female Genital Tract Melis N. Anahtar, Elizabeth H. Byrne, Kathleen E. Doherty, Brittany A. Bowman, Hidemi S. Yamamoto, Magali Soumillon, Nikita Padavattan, Nasreen Ismail, Amber Moodley, Mary E. Sabatini, Musie S. Ghebremichael, Chad Nusbaum, Curtis Huttenhower, Herbert W. Virgin, Thumbi Ndung’u, Krista L. Dong, Bruce D. Walker, Raina N. Fichorova, and Douglas S. Kwon PMID: 25992865

7/2/2015 Ronnie Russell

Differential regulation of NF-κB-mediated proviral and antiviral host gene expression by primate lentiviral Nef and Vpu proteins. Sauter D1, Hotter D2, Van Driessche B3, Stürzel CM2, Kluge SF2, Wildum S2, Yu H2, Baumann B4, Wirth T4, Plantier JC5, Leoz M5, Hahn BH6, Van Lint C3, Kirchhoff F7. PMID: 25620704

6/17/2015 Kitu Kumar

Effects of the I559P gp41 change on the conformation and function of the human immunodeficiency virus (HIV-1) membrane envelope glycoprotein trimer. Alsahafi N1, Debbeche O2, Sodroski J3, Finzi A4. PMID: 25849367

6/4/2015 George Leslie

CD4 mimetics sensitize HIV-1-infected cells to ADCC. Richard J1, Veillette M1, Brassard N2, Iyer SS3, Roger M1, Martin L4, Pazgier M5, Schön A6, Freire E6, Routy JP7, Smith AB 3rd8, Park J8, Jones DM8, Courter JR8, Melillo BN8, Kaufmann DE9, Hahn BH10, Permar SR11, Haynes BF11, Madani N12, Sodroski JG12, Finzi A13. PMID: 25941367

5/21/2015 Son Nguyen

HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4 T Lymphocytes, Lia Vassena, Erica Giuliani, Herwig Koppensteiner, Sebastian Bolduan, Michael Schindler, Margherita Doria PMID: 25822027

5/7/2015 Melanie Duncan

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 Caskey et al. 2015

4/23/2015 Jean L. Scholz Intra-Spike Crosslinking Overcomes Antibody Evasion by HIV-1. Galimidi RP et al. Cell 2015 PMID: 25635457
4/9/2015 Katie Wetzel AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges. Gardner et al. Nature PMID: 2015 25707797
3/12/2015 Brenda Salantes B cell follicle sanctuary permits persistent productive simian immunodeficiency virus in elite controllers, Nat Med 2015
2/12/2015 Rachel Liebman Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Deng et al., Nature 2015
1/29/2015 Mike Hogan Tetherin Can Restrict Cell-Free and Cell-Cell Transmission of HIV from Primary Macrophages to T Cells, PLOS 2014
1/15/2015 Brenda Salantes Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Barouch et al, Nature 2013
2014    
12/6/2014 Katie Wetzel Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells. Calantone et al, Immunity 2014.
11/20/2014 Ted Krieder Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Pancera et al, Nature 2014
10/23/2014 Melanie Duncan HIV-1-induced AIDS in monkeys. Hatziioannou et al, Science 2014
10/9/2014 Dino Romero RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. Hu et al, PNAS 2014
9/25/2014 Adrienne Swanstrom Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression. Sandler, et al. Nature 2014
9/11/2014 Kitu Kumar Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. Tebas et al. N Engl J Med. 2014
8/28/2014 Mike Hogan Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study. Saez-Ciron et al, PLOS Path 2014.
7/31/2014 Samra Elser The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time. Josefsson et al. PNAS 2013
7/17/2014 Katie Wetzel Proliferation of cells with HIV integrated into cancer genes
contributes to persistent infection
Wagner et al, Science 2014.
6/19/2014 Alex Gill Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication. Kristoff et al, JCI 2014.
6/5/2014 Sarah Elliott Boosting of HIV-1 Neutralizing Antibody Responses by a Distally Related Retroviral Envelope Protein. Uchtenhagen et al, JI 2014
5/22/2014 Dino Romero Long-Acting Integrase Inhibitor Protects Macaques from Intrarectal Simian/Human Immunodeficiency Virus. Andrews et al, Science 2014
5/8/2014 Adrienne Swanstrom Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines. Fukazawa et al. Nat Med 2012
4/24/2014 Melanie Duncan Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues. Fletcher et al PNAS 2013
4/10/2014 Katie Wetzel Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure. Ho et al, Cell 2013
3/27/2014 Sarah Gwyn HIV-1 persistence in CD4+ T cells with stem celllike properties. Buzon et al. Nat Med 2013
2/27/2014 Mike Hogan SAMHD1 restricts HIV-1 infection in resting CD4+ T cells. Baldauf et al Nat Med 2012
2/20/2014 Sarah Gwyn Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Dotish et al, Nature 2014