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Penn Center for AIDS Research

Viral / Molecular Core Virology Services: Primary HIV-1 Isolates

Virology Services | Protoype HIV-1 Strains | Primary HIV-1 Isolates | HIV-1 Mutant Viruses | SIV/SHIV Strains

T-tropic Primary Isolates or X4/SI UG0212 (X4/SI) - Gag subtype A, Env subtype D
Gen Bank: U27399, U13525, AF009396, U08723, U08821, U86532
UG0242(X4/SI) - Gag subtype D, Env subtype D
Gen Bank: U08726, AF009397, U08805, U43386, U08732, U08731, U08730, U08729, U08728, U08727, U08726, U08725, U13532, U13531, U13530, U13529, U13528, U13527, U13526, U86533, U08822
SPL-3 (X4/SI) - spleen tissue isolate- same subject as BL-3 (U. Penn isolate)
Reference: Rana S, Collman RG, J. Virol., 04 1997, 3219-3227
BL-3 (X4/SI) - PBMC isolate - same subject as SPL-3 (U. Penn isolate)
Reference: Rana S, Collman RG, J. Virol., 04 1997, 3219-3227
TYBE (X4/SI) - CSF isolate that is CXCR4-restricted and replicates efficiently in primary macrophages via CXCR4-mediated entry (U. Penn isolate)
Reference: Yi Y, Collman RG. J. NeuroVirol., 2004, VOL 10; SUPP/1, 91-96
M-tropic Primary Isolates or R5/NSI BR-2 (R5/NSI): brain tissue isolate - same patient as BL-2, CSF-2 (U. Penn isolate)
Reference: Rana S, Collman RG, J. Virol., 04 1997, 3219-3227
BL-2 (R5/NSI): blood isolate - same patient as BR-2, CSF-2 (U. Penn isolate)
Reference: Rana S, Collman RG, J. Virol., 04 1997, 3219-3227
CSF-2 (R5/NSI): CSF isolate - same patient as BL-2, BR-2 (U. Penn isolate)
BL-6 (R5/NSI): Blood isolate (U. Penn isolate)
BL-9 (R5/NSI): Blood isolate (U. Penn isolate)
CSF-4 (R5/NSI): CSF isolate (U. Penn isolate)
CSF-9 (R5/NSI): CSF isolate (U. Penn isolate)
DOGE (R5/NSI): CSF isolate (U. Penn isolate)
Reference: Chen et. al., J Virol. 2002 Sept;76(18):9407-19

JAGO (R5/NSI): CSF isolate (U. Penn isolate)
Reference: Chen et. al., J Virol. 2002 Sept; 76(18):9407-19

ASM71 (R5)
Reference: Buchbinder SP, et al. AIDS 8:1123, 1994.
ASM93534 (R5)
Reference: Buchbinder SP, et al. AIDS 8:1123, 1994.
TYBE (X4/SI): Note: this CSF isolate is CXCR4-restricted but replicates efficiently in primary macrophages via CXCR4-mediated entry (U.Penn isolate)
Reference: Yi et. al., J Neurovirol. 2003 Aug;9(4):432-41
Neonatal Isolates 302056 (R5/NSI) - Env subtype B. (neonatal isolate from In Utero infection)
Gen Bank: U79719
302072 (R5/NSI) (neonatal isolate - In Utero infection)
302076 (R5 & X4/ SI) (neonatal isolate)
302142 (R5/NSI) (neonatal isolate possible In Utero infection)
302151 (R5X4/SI) (neonatal isolate possible In Utero infection)
Dual-tropic Primary Isolates 93UG086 (R5X4/SI) -Env subtype D.
93US43 (R5X4)
93BRO20 (R5X4/SI) -Gag subtype F, envelope subtype F.
Gen Bank: U51290 U27401
92HT594 (R5X4/SI) -Envelope subtype B
Gen Bank: U08445 U04902
96USHIPS9 (R5X4) -Envelope subtype B
Reference: Ellenberger DL, et al. J Infect Dis 180:1033, 1999.
96USHIPS4 (R5X4) -Envelope subtype B
Reference: Sullivan PS, et al. AIDS 13:89, 1999; Ellenberger DL, et al. J Infect Dis 180:1033, 1999.
BZ167 (R5X4/SI) -Envelope subtype B
Gen Bank: L22087 L11752
Reference: Louwagie J, et al. AIDS Res Hum Retroviruses 10:561, 1994 . Zolla-Pazner S, Sharpe S. AIDS Res Hum Retroviruses 11:1449, 1995.
ASM44 (R5X4)
Reference: Buchbinder SP, et al. AIDS 8:1123, 1994.
Drug-Resistant Isolates 964-G691-6
AZT-Resistant-H1122 (R5X4)
Reference: Larder BA, Darby G, Richman DD. Science 243:1731, 1989.
AZT-Resistant-G9106 (R5X4)
Reference: Larder BA, Darby G, Richman DD. Science 243:1731, 1989.
Nevirapine-R (N119) (X4)
Reference: Richman D, et al. Proc Natl Acad Sci USA 88:11241, 1991; Hara H, et al. AIDS Res Hum Retroviruses 13:695, 1997.
Saquinavir-Resistant
Reference: Jacobsen H, et al. Virology 206:527, 1995.
Cat# 2840 (X4)
Reference: Condra JH, et al. Nature 374:569, 1995.
Cat# 2841 (R5X4)
Reference: Condra JH, et al. Nature 374:569, 1995.

Transmitted Founder Isolates

THRO (R5) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH058 (R5) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH077 (R5/X4) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
ZM249M (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
ZM247Fv1 (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
ZM247Fv2 (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH042 (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH164 (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH185 (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH200b (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH470 (R5) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
REJO (R5) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH040 (R5) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
RHPA (R5) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH607 (R5) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH106 (R5) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH228a (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
WITO (R5) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
Chronic Control Isolates STCOr1 (R5/X4) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
WARO (R5) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
RHGA (R5) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH269 (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH167 (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH293 (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH440 (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH534 (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
CH457 (R5) - Envelope subtype C
Reference: Parrish NF, et al. PNAS 110:17, 2013.
STCOr2 (R5/X4) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.
MCST (R5) - Envelope subtype B
Reference: Parrish NF, et al. PNAS 110:17, 2013.

Virus can be obtained by completing the Reagent Request Form and calling 215-898-5180 to arrange pickup.
* molecularly cloned virus (others are uncloned isolates).
1 Requires compliance with MTA guidelines, available from the Virus Core.
2 UNAIDS isolate which requires registration with NIH AIDS Reference Reagent Program and compliance with MTA guidelines.