Nonhuman Primate Core
The Nonhuman Primate Core provides highly integrated clinical management and laboratory investigations using the non-human primate model of AIDS to CFAR investigators.
The Core, located at the Tulane National Primate Research Center (TNPRC) in Covington, LA, builds on the resources and mission of the TNPRC, which, in part, is to serve as a national resource and center of excellence for biomedical research using non-human primates. Thus, the Center has extensive experience facilitating the interaction of investigators at other institutions with the resources of the center. This includes a variety of centralized services as well as fully equipped laboratory space available to visiting investigators.
The Core acquires houses and cares for macaques used by CFAR members. The core is responsible for regulatory compliance and the daily clinical care of animals and animal procedures such as immunizing the animals, collection of body fluids (blood cerebrospinal fluid, saliva, etc.), bronchoalveolar lavage, biopsies, surgery etc.
The laboratory component of the Core performs hematology, clinical chemistry, ova and parasite examination of feces, flow cytometry, microbiology, and pathologic examination of all necropsies and biopsies performed on animals utilized in these studies. The Core also provides viral stocks, viral isolation, immunology, molecular pathology and confocal microscopy services.
In addition to its mission of service to the Penn CFAR, the Core also serves to stimulate the translation of bench-based findings into animal experimentation, a key necessary step prior to application of any results to humans. One major tool in this effort is a pilot research program using non-human primates offered in conjunction with the Developmental Core. The Call for Proposals for the Nonhuman Pilot Research Program is usually offered once a year in late summer or early fall. The pilot program is open to all Penn CFAR investigators at Penn, CHOP, and Wistar.
- Nonhuman Primate Pilot Grant Program
- Regulatory oversight and assistance in acquiring nonhuman primates
- Consultation on study design for nonhuman primate studies
- Routine veterinary care and husbandry
- Perform aspects of HIV-related research studies using nonhuman primates
- Clinical Laboratory Services
- Anatomic Pathology
- Confocal microscopy and image analysis
- Flow cytometry and immunology
- Viral characterization, isolation and production