Nonhuman Primate Pilot Grant Program
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Vetrinarians from the Division of Veterinary Medicine at TNPRC perform video assisted thoracoscopic surgery on a rhesus monkey. Minimally invasive endoscopic surgery minimizes surgical morbidity and provides for a more rapid recovery when compared to open surgical techniques. |
To facilitate opportunities for Penn CFAR investigators to utilize the nonhuman primate model of AIDS, our recently funded Nonhuman Primate (NHP) Core includes animals and animal support for Penn CFAR developmental studies. The goal of this program is to allow an investigator to accumulate sufficient data and expertise to apply for an independent NIH grant. Funds are available for the procurement and care of animals, including appropriate animal laboratory studies (collection of body fluids, biopsies, surgeries, necropsies and basic or SIV-specific laboratory studies). This will permit funding for 1 or 2 projects each year, depending on the number of animals requested and the length of the project. Laboratory studies performed at Penn will be the responsibility of the investigator, and there are no funds available for salary support. All Penn CFAR investigators are eligible for these pilot funds.
TNPRC Investigators:
| Dr. Andrew A. Lackner alackner@tulane.edu |
Dr. Preston Marx pmarxj@tulane.edu |
Dr. Ron Veazey rveazey@tulane.edu |
Previous Nonhuman Primate Pilot Projects
| Year | Investigator | Title of Project |
| 2011 | Sita Awasthi, Ph.D., Harvey Friedman, M.D. | Evaluation of Immunogenicity and efficacy of a HSV-2 trivalent vaccine in macaque model of HSV-2 vaginal infection |
| 2011 | Beatrice Hahn, M.D., Nick Parrish | Transmissibility of a SIVmac239 Mutant with increased Env content |
| 2011 | George Shaw, M.D., Ph.D. | Hypermutation in the 5' Untranslated Region (5' UTR) of SIVmac 251/239: A Novel Mechanism of Virus Containment and Escape |
| 2010 | James Hoxie, M.D. | In vivo studies of a novel CD4-independent variant of SIVmac239 |
| 2010 | Una O'Doherty, Ph.D., |
SIV Reservoir Size and Location in Chinese Rhesus Macaques Progressors and Nonprogressors |
| 2010 | John Wherry, Ph.D., Charley Kao |
T-bet-dependent regulation of CD8 T cell exhaustion and PD-expression during SIV infection |
| 2009 | Robert Doms, M.D., Ph.D. | Zinc finger nuclease-mediated disruption of HIV-1 coreceptors |
| 2009 | Dennis Kolson, M.D., Ph.D. Francisco Gonzalez-Scarano, M.D. | Oral dimethyl fumarate (BG-12), Funaderm?, an immune modulator and novel candidate central nervous system (CNS) neuroprotectant against SIV/HIV |
| 2008 | Ronald Collman, M.D. | Gut Microbial Modification in SIV Immune Activation |
| 2008 | Fred Frankel, Ph.D. | Intranasal Challenge |
| 2008 | Samuel Parry, M.D. and Preston Marx, Ph.D. | Heterosexual Transmission of HIV: The Uterus as a Critical Target |
| 2007 | Jean Boyer, Ph.D. | The Impact of Parasitic Infection on AIDS Vaccines |
| 2007 | Dennis Kolson, M.D., Ph.D. and Kelly Jordan-Sciutto, Ph.D. | The Integrated Stress Response (ISR) in SIV Neuropathogenesis |
| 2007 | Elena Perez, M.D., Ph.D. and Carl June, M.D. | NHP CCR5 ZFNs Proof of Concept |
| 2006 | Frederic Bushman, Ph.D. | Lentiviral Infection and Dynamics of the Gut Microbial Flora |
| 2005 | Luis Montaner, D.V.M., D.Phil. and Andrew Lackner, D.V.M., Ph.D. | TALL-104 Cell Inhibition of SIV Infection |
| 2005 | David B. Weiner, Ph.D. | Directing Lymphoid Compartments by DNA Vaccines |
| 2004 | Steven D. Douglas, M.D. | Pilot Study of the Safety, Tolerability, and Pharmacokinetics of Aprepitant, a Neurokinin-1R Receptor Antagonist, in Uninfected and SIV-infected Rhesus Macaques |
| 2004 | Drew Weissman, Ph.D. | Analysis of Viral and Immune Response in Lymph Nodes of Virologically Suppressed SIV-infected Macaques |