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Penn Center for AIDS Research

Developmental Core: Penn CFAR Pilot Grant Program in HIV/AIDS

Mission | Pilot Awards | Mentoring Program | Personnel | Contact Info

CMV retinitis
The same eye with CMV retinitis before and after treatment with a ganciclovir implant. (Kempen Pilot)

The major goal of the Developmental Core is the promotion of AIDS- and HIV-related research at the University of Pennsylvania, The Children's Hospital of Philadelphia, and The Wistar Institute by providing a source of funding for pilot projects. The Developmental Core supports short-term (one year) projects in emerging areas of HIV research, including new research related to the recruitment of new investigators, research by established investigators who are turning their attention to AIDS, and research by AIDS/HIV investigators who are undertaking studies that represent a significant departure from their previous work.

We are not currently accepting applications for CFAR Developmental Pilot Awards. The next application period will be in the Spring of 2015.

In the meantime, view the most recent Developmental Pilot RFA.

A Developmental Pilot Pre-Application Workshop was held on Friday, January 24. Investigators interested in applying for a Developmental Pilot are encouraged to view the video of the presentations.


Recipients of the Developmental Core Pilot Grants in HIV/AIDS

Year Investigators Title of Project
2014 Ritapurna Das, M.D., Ph.D. (Medicine/ID), Harvey Friedman, M.D. (Medicine/ID) Role of MIF in Host Immunity to Tuberculosis Amount HIV-Infected Individuals
2014 Malitta Engstrom, Ph.D., LCSW (School of Social Policy & Practice) Community reinforcement and family therapy with men leaving prison and their female partners
2014 David Issadore, Ph.D (Bioengineering), Gregory Bisson, M.D. (Medicine) The ultra-sensitive detection of rare mycobacterium tuberculosis using a µHall chip
2014 Helen Koenig, M.D., MPH. (Medicine, ID), Karam Mounzer, M.D. (Medicine) Validation of a urine assay for the measurement of tenofovir levels as a means of monitoring adherence to truvada given as pre-exposure prophylaxis for HIV prevention
2014 Emilio Parrado, Ph.D. (Sociology), Felicia Lewis, M.D., CDR, USPHS (Philadelphia Dept of Health) HIV risks and health care access among Mexican and Central American immigrants in Philadelphia
2014 Xiaolu Yang, Ph.D. (Cancer Biology), Jim Riley, Ph.D. (Microbiology) Restriction of HIV by TRIM5a: mechanism and potential therapeutic application

2013

 

Abass Alavi, M.D. (Radiology), Pablo Tebas, M.D. (Medicine/ID) Assessment of cardiovascular and central nervous system complications of HIV/AIDS by PET/CT imaging
2013 Katharine Bar, M.D. (Medicine/ID) Viral Dynamics of HIV-1 Rebound Viremia
2013 Henry Kranzler, M.D. (Psychiatry), David Metzger, Ph.D. (Psychiatry) Cognition as a Potential Mediator of Alcohol Use and Poor ART Adherence in HIV+ Drinkers
2013 Lilie Lin, M.D. (Radiation Oncology), Surbhi Grover (Medicine), Doreen-Ramogola-Masire (Botswana-UPenn) Impact of HIV infection and treatment on tolerability of cervical cancer therapy
2013 Deirdre Sawinski, M.D. (Medicine/ Renal), and Emily Blumberg M.D. (Medicine) Effect of rATG on HIV reservoirs in HIV+ kidney transplant recipients
2013 Jean Scholz, Ph.D. (Pathology & Lab Med), Michael Cancro (Pathology & Lab Med) Are potentially broadly neutralizing clonotypes eliminated at peripheral selection checkpoints?
2012 David Artis, Ph.D. (Microbiology), Gregory Sonnenberg, Ph.D. (Microbiology) Immune regulation of intestinal barrier function following SIV infection
2012 Paul Bates, Ph.D. (Microbiology) NFkB activation by Tetherin
2012 Haim H. Bau, Ph.D. (Engineering), Changchun Liu, Ph.D. (Engineering), and Robert Gross, M.D., M.S.C.E. (Medicine/ID; CCEB) Point of Care, Integrated System for Molecular Detection of HIV
2012 Hans-Peter Kohler, Ph.D. (Sociology) and Iliana Kohler, Ph.D. (PSC) Mental Health, HIV and Aging in a poor high-risk disease environment: A pilot study in rural Malawi
2011 Jennifer Cohn, M.D. (Medicine/ID) Mobile telecommunication solutions to improve HIV patient care at the community level in Kenya
2011 Ron Collman, M.D. (Med/Pulmonary) and Anjana Yadav, Ph.D. (Medicine); Dennis Kolson, M.D., Ph.D. (Neurology) Stain modulation of monocyte activation: a pilot study for potential use in NeuroAIDS
2011 Dennis Dlugos, M.D., M.S.C.E (Neurology at CHOP) and David Bearden, M.D. (Neurology at CHOP) Risk Factors for Seizures in Children with HIV/AIDS in Botswana
2011 David Metzger, Ph.D. (Psychiatry) and Sumedha Chhatre, Ph.D. (Psychiatry) Effects of stress reduction on chronic immune activation and inflammation
2011 Shikata Mudakha, M.D. (Medicine/ID) and Mary Kestler, M.D. (Medicine/ID); Harvey Friedman, M.D. (Medicine/ID) Developing a TB screening algorithm for coughers presenting for inpatient care in an arear of high HIV prevalence
2011 Virginia Stallings, M.D. (Pediatrics, CHOP) Botswana Vitamin D Supplementation Study in HIV/AIDS
2010 Sita Awasthi, Ph.D. (Medicine/ID) To establish a humanized mouse model for HSV-2 and HIV-1 Co-infection
2010 Ron Collman, M.D., (Med/Pulmonary) and Nicola Zetola, M.D. (Botswana) Alcoholism and MDR TB in HIV patients in Botswana
2010 Andrea Doyle, Ph.D. (Social Policy & Practice) and Jeffrey Draine, Ph.D., (Social Policy & Practice) Healthcare engagement of women who test positive for HIV in a vaccine trial
2010 Robert Gross, M.D., MSCE (Medicine) and Elizabeth Lowenthal, M.D. Psychosocial Assessments of HIV-infected children and adolescents in Botswana
2010 Carrie Kovarik, M.D. (Dermatology) and Rahat Azfar, M.D. The use of mobile telemedicine for remote diagnosis of HIV-infected patients in Botswana
2010 Daniel Langleben, M.D. (Psychiatry) and Daniel Romer, Ph.D. (Annenberg) Functional MRI of Brain Response to HIV Prevention Public Service Announcements
2010 Vincent Lo Re, M.D., (Medicine, ID) and Mary Leonard, M.D., MSCE A structural approach to bone disease due to Hepatitis C co-infection in HIV
2010 Zhengyu Ma (CHOP) and Dennis Discher, Ph.D. (Engineering) Probing the mechanism of HIV TCR specificity using atomic force microscopy
2010 Jon Merz, J.D., Ph.D. (Medical Ethics) and Francis Barchi, M.S. Botswana Ethics Training Initiative: Using web-based tools to enhance learning and skills-development in research ethics training of host-country HIV/AIDS
2010 Andrew Steenhoff, M.D. (Pediatrics) and Nicola Zetola, M.D. Novel diagnostics for pediatric tuberculosis
2009 Stefania Gallucci, M.D.(Pediatrics), and David Weiner, Ph.D. (Path/Lab Medicine) Clonogenic Progenitors of Dendritic Cells as Novel Antigen Carrier in anti-HIV
2009 Toorjo Ghose, M.S.W., Ph.D. (Social Policy & Practice) Implementing PATH-India: Reducing HIV Risk Among the Dually Diagnosed in India
2009 John Kempen, M.D, M.H.S., M.P.H., Ph.D. (Opthalmology), and Maureen Maguire, Ph.D. (Opthalmology) Pilot Study in Preparation for the Intravitreous Ganciclovir-Valganciclovir Cytomegalovirus Retinitis Trial (GIVCyT)
2009 Steven Marcus, Ph.D. (Social Policy & Practice), and Julie Cederbaum, M.S.W.,M.P.H. (Social Policy & Practice) HIV Serostatus and its Influence on Mother Influence Behaviors and Adolescent Engagement in HIV Risk Behaviors
2009 Doreen Ramogola, M.D. (Women's Health, University of Botswana), and Harvey Friedman, M.D. (Medicine, ID) Epidemiology of HPV Infection in HIV-infected Women with Precancerous Cervical Lesions in Botswana
2009 Samir Shah, M.D., M.S.C.E.. (Pediatrics, Epidemiology), and Zsofia Szep, M.D. (Medicine, ID) Association of Serum Vitamin D Levels and Insulin Resistance Among Patients Infected w/Human Immunodeficiency Virus
2008 Frederic Bushman, Ph.D. (Microbiology) The Macaque Gut Microbiota and SIV Infection
2008 Branch Coslett, M.D. (Neurology) and Kathy Lawler, M.D. (Neurology) Assessment of HIV-Related Dementia and Depression in Botswana
2008 Roy Kim, M.D. (Pediatrics) and Ian Frank, M.D. (Medicine, ID) Effects of Recombinant IGF-I in HIV-Associated Metabolic Disease
2008 Susan Ross, Ph.D. (Microbiology) Development of an in vivo Model to Study APOBEC3G/vif Interaction
2008 Courtney Schreiber, M.D. (OB/GYN) How to Avoid Pregnancies in HIV Prevention Trials: a Case-Control Study and Point-of-Care Questionnaire
2008 Anne Teitelman, Ph.D. (Nursing); Loretta Sweet Jemmott, Ph.D. (Nursing); Therese S. Richmond, Ph.D. (Nursing); and William Holmes, M.D. (Medicine/Epidemiology) HIV/STI Risk Reduction for African-American Adolescent Girls: Addressing the Context of Partner Abuse
2007 John B. Jemmott, III, Ph.D. (Psychiatry) and G. Anita Heeren, M.D., MSc., Ph.D. (Annenberg School of Communication) HIV/STI Risk Reduction for African American Men
2007 Shane T. Jensen (Statistics, Wharton) and Jon D. McAuliffe (Statistics, Wharton) Spatially Varying Evolutionary Models of Viral Escape Response
2007 Dennis Kolson, M.D., Ph.D. (Neurology) and Julio Martin-Garcia, Ph.D. (Microbiology/Immunology, Drexel) Neurotropism and Neurovirulence of Subtype C HIV-1 Isolates from Botswana
2007 Ian C. MacMillan, MBA, DBA (Wharton); Darren Linkin, M.D. (Medicine, ID); James Thompson, MBA, Ph.D. (Wharton); Alan Abrahams, Ph.D. (Wharton); Diana Dickenson, M.D. (Clinician in Gaborone, Botswana); and Peter Ehrenkranz, M.D., MPH (Clinical Scholars, Penn) A Pilot Study of Cellular Phone Text Message Reminders to Improve HIV Medication Adherence in the Developing World
2007 Erle Robertson, Ph.D. (Microbiology) and Gregory Bisson, M.D., M.S.C.E. (Medicine, ID) Identification of an Etiological Basis Associated with Ocular Surface Squamous Neoplasia
2007 Guido Silvestri, M.D. (Pathology and Laboratory Medicine) and Ian Frank, M.D. (Medicine, ID) Mucosal Immune Activation in HIV-infected Patients
2006 Yair Argon, Ph.D. (Pathology and Laboratory Medicine) and Stefania Gallucci, M.D. (Pediatrics, Children’s Hospital) Augmenting the Presentation of HIV Peptides to T cells using an Engineered Chaperone Protein
2006 Michael Betts, Ph.D. (Microbiology) and Ian Frank, M.D. (Medicine, ID) Modulation of HIV-specific CD8+ T cell Function and Control of HIV Replication During and After Cessation of HAART
2006 Arthur Caplan, Ph.D. (Medicine, Medical Ethics) An Ethical Framework for HIV Vaccine Research
2006 Sridhar Hannenhalli, Ph.D. (Genetics) and Frederic Bushman, Ph.D. (Microbiology) Computational Analysis of HIV-1 Integration in the Human Genome
2006 Nancy Hanrahan, Ph.D. (School of Nursing) Quantifying Nurse Interventions in the Treatment of Individuals with Serious Mental Illness and HIV
2005 Randy Cron (Pediatrics, Children’s Hospital) and Pablo Tebas (Penn Medicine, ID) NFAT Activity in CsA-Treated HIV-1-Infected Individuals
2005 Stefania Gallucci (Pediatrics, Children’s Hospital) and Terri Finkel (Pediatrics, Children’s Hospital) Activating Anti-HIV Dendritic Cells by Abnormal Cell Death
2005 Edward George (Statistics, Wharton) Exploratory Markov Modeling of Discrete Biomarkers
2005 David Oslin (Medicine, Psychiatry) Aging Among HIV-infected Individuals as a Risk for Cognitive Decline and Poor Adherence
2005 Pablo Tebas (Medicine, ID) Prevalence of HCV and HBV Among HIV Positive Patients in the Dominican Republic
2004 Harvey Friedman (Medicine, ID) and Gregory Bisson (Medicine, ID) Virologic Effectiveness, Predictors of Virologic Failure and Development of a Clinical Prediction Rule for Virologic Success in the Botswana National ARV Program
2004 John Detre (Neurology) and Beau Ances (Neurology) Brain Activation Using fMRI in Asymptomatic, Mild Cognitive Motor Deficit, and AIDS Dementia Patients
2004 Muredach P. Reilly (Medicine, Cardiovascular Division) Pilot Study of the Genetics of ART-associated Dyslipidemia in HIV
2004 Hao Shen (Microbiology) Role of CD4 Help in Heterologous Prime-Boost Immunization
2003 Li-Wei Chao (Anesthesiology, Children’s Hospital) and Mark Pauly (Wharton) Educator and Pupil Training in HIV/AIDS in South Africa
2003 Andrew Dancis (Medicine, Hematology/Oncology) Roles for Three Distinct Iron Uptake Systems in Mucosal Infections by Candida albians
2003 Paul Lieberman (The Wistar Institute) Regulation of Kaposi's Sarcoma-Associated Virus Reactivation
2003 Gerd Maul (The Wistar Institute) Improvement for Gag DNA Vaccine Vector by Nuclear Targeting
2003 Barbara Turner (Medicine) and Kathleen Brady (Medicine) Unlinked Seroprevalence Testing of Hepatitis C in Inpatients
2002 Jean Boyer (Pathology and Laboratory Medicine) A Polarized Th2 Immune Response Can Decrease HIV-1 Vaccine Efficacy
2002 Robert Doms (Microbiology) Analysis of Envs from HIV-infected Children in Nairobi, Kenya
2002 J. Kevin Foskett (Physiology) Interaction of HIV Nef with the Inositol Trisphophate Receptor Intracellular Ca2 Release Channel
2002 Kaivan Munshi (Economics, School of Arts and Sciences) Marriage and Sexual Behavior: With an Application to Urban Migrants in Kisumu, Kenya
2002 James Riley (Pathology and Laboratory Medicine) Control of CCR5 Expression in Primary CD4 T Cells
2001 Michael Blank (Psychiatry) and Aileen Rothbard (Psychiatry) Co-Occurrence of HIV/AIDS Among Persons with Severe Mental Illness
2001 Bruce Freedman (Animal Biology, School of Veterinary Medicine) Mechanism of HIV-1 gp120 Induced Capping on Primary Human Macrophages
2001 Samuel Parry (Ctr for Research on Reproduction and Women’s Health) Transmission of Human Immunodeficiency Virus Across the Placenta
2001 William Swiggard (Medicine, ID) Interactions of Circulating Human Dendritic Cells with HIV-1
2000 Jeffrey Field (Pharmacology) Role of Pak kinases in Kaposi's Sarcoma
2000 Stuart Isaacs (Medicine, ID) Development of Novel Recombinant Vaccinia Virus Based anti-HIV Vaccines
2000 Robert Ricciardi (Microbiology, School of Dental Medicine) A Novel Approach for Identifying HHV-8 Anti-virals
2000 Antonia Villarruel (School of Nursing) Effectiveness of an HIV Risk Reduction Intervention for Spanish-speaking Latino Youth
2000 Susan Watkins (Sociology) and Jere Behrman (Economics) Social Science Aspects of Intergenerational and Intragenerational Interactions Related to HIV/AIDS in a High HIV/AIDS Incidence sub-Saharan Population