TB/HIV Coinfection Home
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University of Massachusetts CFAR
Chris Sassetti: firstname.lastname@example.org
1. HIV/TB Co-infection Projects:
- Drs. Mario Stevenson and Christopher Sassetti are investigating the mechanisms by which HIV promotes Mtb growth in coinfected macrophages. Contact: Christopher.email@example.com, firstname.lastname@example.org
- Dr. Paul Clapham is collaborating with Dr. David Russell (Cornell, Ithaca) to investigate the effect of HIV infection on the antibacterial properties of the macrophage. Contact: Paul.email@example.com
2. HIV/TB Researchers:
3. Inter-CFAR Shared Resources:
- The Virology Core facility functions as a resource for Virus, Cells, and Molecular Virology Assays. It will provide Phenotyping service, Screening service and Qualitative/Quantitative Detection service to the participating CFAR investigators. The facility will have standardized and centralized routine research techniques and reagents available for the investigators.
- BSL3 flow cytometer. The BSL3 FACS Aria is configured with 5 parameters on the 488nm laser, 3 parameters on the 633nm laser, 3 parameters on the 405nm laser, and 3 parameters on the 350nm laser. This machine is housed in a BSL3 facility allowing sorting unscreened human and/or infectious samples up to biosafety level 3.
- Humanized mouse models. Dr. Robert Woodland has generated human/mouse chimeras in which the development of the human lymphocyte compartment is promoted by the addition of species-restricted cytokines. This mouse model is currently in use to test HIV vaccine candidates and may be useful as a coninfection model.