CIRNA Research

The mission of the University of Pennsylvania Center for Interdisciplinary Research on Nicotine Addiction (CIRNA) is to translate discoveries in basic neuroscience, pharmacology, genetics, and behavioral science to improve treatment for nicotine addiction.

The Penn CIRNA is currently conducting several research projects.

 

CIRNA Research Projects:

• Molecular and Behavioral Analysis of Nicotine Dependence (Project 1) - Blendy/Gould
• Neural Substrates of Smoking Cessation and Medication Response ( Project 2) - Lerman
• Early Human Screening for Cessation Medications (Project 3) - Perkins

CIRNA-Related Research Grants:

Behavioral Neuroscience

• Genetic, Behavioral, & Neurobiological Substrates of Nicotine Withdrawal, R01-DA-024787 (Gould)
• Nicotine Addiction: Learning, Neural & Genetic Process, R01-DA-017949 (Gould)
• Neural Substrates of Cognitive Deficits in Nicotine Withdrawal, R01-DA-026849 (Lerman/Loughead)   

Behavioral Pharmacology

• Extinction of Smoking Topography and Behaviors During Response to Varenicline, IIR #GA30523L (Strasser)
• Tobacco Smoking, Nicotine, and Negative Affect Relief, R01-DA-19478 (Perkins) - Click here for more information.

Genetics

• Behavioral Genetics of Mood-induced Smoking, R01-DA-027449 (Perkins)
• Functional Characterization of OPRM1 A118G in Nicotine Dependence, R21-DA-027066 (Blendy/Lerman)
• Nicotine Abstinence-Induced Cognitive Alterations by COMT Genotype, R03-DA-027438 (Lerman/Loughead)  
• Pharmacogenetics of Nicotine Addiction Treatment, U01-DA-020830 (Lerman/Tyndale)

Youth Smoking

• Longitudinal Patterns and Predictors of Smoking Behavior, R01-CA-109250 (Audrain-McGovern)
• Protective Effects of Physical Activity on Adolescent Smoking Progression, R01-CA-126958 (Audrain-McGovern)

Treatment/Medication Development

• Center for Interdisciplinary Research on Nicotine Addiction (CIRNA), P50-CA-143187 (Lerman/Blendy)
• An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence, R01-DA-025078-01 (Schnoll)
• Assessment of a Teachable Moment for Smoking Cessation, R01-CA-126969 (Schnoll)
• Assessment of High Dose Transdermal Nicotine for Fast Metabolizers of Nicotine, R21-DA-026889 (Schnoll)
• Comparing the Lozenge to the Patch for Smoking Cessation, RSGPB-05-240-01-CPPB (Schnoll)

Tobacco Products and Marketing

• Biomarkers of Toxic Response to Low Nicotine Cigarette Smoke, R01-CA-130961 (Strasser/Blair)
• Effects of Smoking Cues in Anti-Tobacco PSAs (CECCR) (Project 2), P50-CA-095856 (Strasser/Capella)
• Smoking Topography and Harm in a New PREP, R01-CA-120594 (Strasser)