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Falk W. Lohoff, MD
Assistant Professor of Psychiatry
Department of Psychiatry faculty bio
Mood and Anxiety Disorder Treatment & Research Program bio

Dr. Lohoff’s research interest is in the genetics and pharmacogenetics of mood and anxiety disorders. Dr. Lohoff has expertise in the identification of molecular genetic targets of complex psychiatric diseases. His focus is on human genetic association studies with translational aspects using in vivo/vitro systems and animal models to verify identified risk alleles. This includes current investigation of presynaptic vesicular monoamine transporters as targets for novel drug development. Dr. Lohoff is also establishing a clinical psychiatric pharmacogenomics program investigating new biomarkers that predict treatment outcome.

Falk W. Lohoff, MD
Assistant Professor of Psychiatry
Perelman School of Medicine at the University of Pennsylvania
Department of Psychiatry
Center for Neurobiology and Behavior
Translational Research Laboratories
125 South 31st Street, Room 2213
Philadelphia, PA 19104
Office: (215) 573-4582
Fax: (215) 573-2041
lohoff@mail.med.upenn.edu

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Participate in Dr. Lohoff's research on Bipolar Disorder

Learn more about the Pharmacogenomics of Bipolar Disorder International Study

Publications

Click here to view publications in PubMed

Lohoff FW, Ferraro TN. Pharmacogenetic considerations in the treatment of psychiatric disorders. Expert Opin Pharmacother. 2010 Feb;11(3):423-39. Review. PubMed PMID: 20102306.

Lohoff FW, Ferraro TN, Brodkin ES, Weller AE, Bloch PJ. Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2010 Apr 5;153B(3):830-6. PubMed PMID: 19859903.

Bloch PJ, Weller AE, Doyle GA, Ferraro TN, Berrettini WH, Hodge R, Lohoff FW. Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 26. [Epub ahead of print] PubMed PMID: 20800640.

Smith EN, Bloss CS, Badner JA, Barrett T, Belmonte PL, Berrettini W, Byerley W, Coryell W, Craig D, Edenberg HJ, Eskin E, Foroud T, Gershon E, Greenwood TA, Hipolito M, Koller DL, Lawson WB, Liu C, Lohoff F, McInnis MG, McMahon FJ, Mirel DB, Murray SS, Nievergelt C, Nurnberger J, Nwulia EA, Paschall J, Potash JB, Rice J, Schulze TG, Scheftner W, Panganiban C, Zaitlen N, Zandi PP, Zöllner S, Schork NJ, Kelsoe JR. Genome-wide association study of bipolar disorder in European American and African American individuals. Mol Psychiatry. 2009 Aug;14(8):755-63. Epub 2009 Jun 2. PubMed PMID: 19488044.

Lohoff FW, Weller AE, Bloch PJ, Nall AH, Ferraro TN, Kampman KM, Pettinati HM, Oslin DW, Dackis CA, O'Brien CP, Berrettini WH. Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence. Neuropsychopharmacology. 2008 Dec;33(13):3078-84. Epub 2008 Aug 13. PubMed PMID: 18704099; PubMed Central PMCID: PMC2583214.

Lohoff FW, Weller AE, Bloch PJ, Nall AH, Ferraro TN, Berrettini WH. Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder. J Neural Transm. 2008 Sep;115(9):1339-45. Epub 2008 Jul 30. PubMed PMID:18665321.

Lohoff FW, Dahl JP, Ferraro TN, Arnold SE, Gallinat J, Sander T, Berrettini WH. Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder. Neuropsychopharmacology. 2006 Dec;31(12):2739-47. Epub 2006 Aug 23. PubMed PMID: 16936705; PubMed Central PMCID: PMC2507868.

Lohoff FW, Sander T, Ferraro TN, Dahl JP, Gallinat J, Berrettini WH. Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder. Am J Med Genet B Neuropsychiatr Genet. 2005 Nov 5;139B(1):51-3. PubMed PMID: 16152572.

Buono RJ, Lohoff FW, Sander T, Sperling MR, O'Connor MJ, Dlugos DJ, Ryan SG, Golden GT, Zhao H, Scattergood TM, Berrettini WH, Ferraro TN. Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility. Epilepsy Res. 2004 Feb;58(2-3):175-83. PubMed PMID: 15120748.

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