Recent Publications from CNDR

Here is a selection of recent publications from CNDR:

2008

2007

2006

• Brunden, K.R., Trojanowski, J.Q., Lee, V.M.-Y. Evidence that Non-Fibrillar Tau Causes Pathology Linked to Neurodegeneration and Behavioral Impairments. Submitted 2008.
• Yang, E.J., Kotzbauer, P.T., Lee, E., Trojanowski, J.Q., and. Lee, V.M.-Y. The ubiquitin proteasome system and Parkin regulate proteolytic processing and degradation of PINK1. J. Biol. Chem., Submitted, 2008.
• Igaz, L.M., Kwong, L.K., Xu, Y., Traux, A.C., Uryu, H., Neumann, M., Clark, C.M., Ellman, L., Miller, B.I., Grossman, M., McCluskey, L.F., Trojanowski, J.Q., and Lee, V.M.-Y. Enrichment of C-terminal fragments in TDP-43 cytoplasmic inclusions in brain but not in spinal cord of Frontotemporal lobar degeneration and amytrophic lateral sclerosis. Am. J. Pathol., Submitted, 2008.
• Mendez, I., Vinuela, A., Astradsson, A., Mukhida, K., Hallett, P., Robertson, H., Tierney, T., Holness, R., Dagher, A., Trojanowski, J.Q., Isacson, O. Dopamine and serotonin neurons implanted into Parkinson’s disease patients survive for 14 years: implications for etiopathogenesis. Submitted 2008.
• Van Deerlin, V.M., Leverenz, J.B., Bekris, L.M., Bird, T.D., Yuan, W., Elman, L.B., Clay, D., Wood, E.M., McCluskey, L., Grossman, M., Neumann, M., Chen-Plotkin, A.S., Martinez-Lage, M., Wu, I.-L., Yang, W.-S., Kalb, R., Montine, T.J., Trojanowski, J.Q., Lee, V.M., Schellenberg, G.D., Yu, C.-E. Mutations in the TARDBP Gene Cause Amyotrohic Lateral Sclerosis with TDP-43 Neuropathy. Submitted 2008.
• Winton, M.J., Igaz, L.M., Kwong, L.K., Trojanowski, J.Q., Lee, V.M.-Y. Disturbance of nuclear and cytoplasmic TDP-43 leads to disease-like redistribution, sequestration and aggregate formation. Science, Submittted, 2008.
• Uryu, K., Nakashima-Yasuda, H., Forman, M., Kwong, L.K., Clark, C.M., Grossman, M., Miller, B.L., Kretzschmar, H.A., Lee, V.M.-Y., Trojanowski, J.Q., and Neumann, M. Concomitant TDP-43 pathology is present in Alzheimer’s disease and corticobasal degeneration. J. Neuropath. Exper. Neurol., Submitted, 2008.
• Li, W., Sperry, J.B., Crowe, A., Murray, I.V.J, Axelsen, P.H., Trojanowski, J.Q., Smith III, A.B., and Lee, V.M.-Y. Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau. Biochem., Submitted, 2008.
• Chen-Plotkin, A.S., Yuan, W., Anderson, C., Wood, E.M., Hurtig, H.I., Clark, C.M., Lee, V.M.-Y., Trojanowski, J.Q., Grossman, M., Van Deerlin, V.M. Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations. Neurology 70:521-527, 2008.
• Brandmeir, N.J., Geser, F., Kwong, L.K., Zimmerman, E., Qian, J., Lee, V.M-Y., Trojanowski, J.Q. Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease. Acta Neuropathol 115:123-131, 2008.
• Geser, F., Winton, M.J., Kwong, L.K., Xu, Y., Xie, S.X., Garruto, R., Perl, D., Galasko, D., Lee, V.M.-Y., Trojanowsk, J.Q. Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic laterl sclerosis of Guam. Acta Neuropathol 115:133-145, 2008.
• Trojanowski, J.Q. PENN neurodegenerative disease research - In the spirit of Benjamin Franklin. NeuroSignals, 16:5-10, 2008.
• Clark, C.M., Davatzikos, C., Borthakur, A., Newberg, A., Leight, S., Lee, V.M.-Y., and Trojanowski, J.Q. Biomarkers for early detection of Alzheimer pathology. NeuroSignals, 16:11-18, 2008.
• Soper, J.H., Roy, S., Stieber, A., Lee, E., Wilson, R.B., Trojanowski, J.Q., Burd, C.G., Lee, V.M.-Y. Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Molecular Bio of the Cell 19:1093-1103, 2008.
• Kwong, L.K., Trojanowski, J.Q., and Lee, V.M.-Y. TDP-43 proteinopathies: Neurodegenerative protein misfolding diseases without amyloidosis. NeuroSignals, 16:41-51, 2008.
• Chen-Plotkin, A.S., Geser, F. Plotkin, J.B., Clark, C.M, Kwong, L.K., Yuan, W., Grossman, M., Van Deerlin, V.M., Trojanowski, J.Q., and Lee, V.M.-Y. Variations in the Progranulin Gene Affect Global Gene Expression in Frontotemporal Lobar Degeneration. Hum Mol Genet (Epub ahead of print), 2008.
• Rabinovici, G.D., Seeley, W.W., Pagliaro, T.A., Halabi, C., Allison, S.C., Gorno-Tempini, M.L., Johnson, J.K., Weiner, M.W., Forman, M.S., Trojanowski, J.Q., DeArmond, S.J., Miller, B.L., Rosen, H.J. Distinct MRI atrophy patterns in autopsy-proven Alzheimer’s disease and frontotemporal lobar degeneration. Am J Alzheimers Dis Other Demen 22:474-488, 2008.
• Lee, E.B., Lee, V.M.-Y., Trojanowski, J.Q., Neumann, M. TDP-43 Immunoreactivity in Anoxic, Ischemic and Neoplastic Lesions of the Central Nervous System. Acta Neuropath 115:305-311, 2008.
• Xie, S.X., Forman, M.S., Farmer, J., Moore, P., Wang, Y., Wang, X., Miller, B.L., Clark, C.M., Coslett, H.B., Chatterjee, A., Arnold, S.E., Rosen, H., Karlawish, J.H., Van Deerlin, V.M., Lee, V.M.-Y., Trojanowski, J.Q., Grossman, M. Factors Associated with Survival Probability in Autopsy-Proven Frontotemporal Dementia. J Neurol Neurosurg Psychiatry, 79:126-129, 2008.
• Gomes, C., Palma, A., Almeida, R, Regalla, M., McCluskey, L.F., Trojanowski, J.Q., and Costa, J. Establishment of a cell model of ALS disease: Golgi apparatus disruption occurs independently from apoptosis. Biotechnol Lett 30:603-610, 2008.
• Chen-Plotkin, A.S., Yuan, W., Anderson, C., Wood, E.M., Hurtig, H.I., Clark, C.M., Lee, V.M.-Y., Trojanowski, J.Q., Grossman, M., Van Deerlin, V.M. Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations. Neurology 70:521-527, 2008.
• Jedrziewski, M.K., Lee, V.M.-Y., Trojanowski, J.Q. Physical activity and cognitive health. Alzheimer’s & Dementia, Submitted 2007.
• Leverenz, J.B., Hamilton, R., Tsuang, D.W., Schantz, A., Vavrek, D., Larson, E.B., Kukull, W.A., Lopez, O., Galasko, D., Masliah, E., Kaye, J., Nixon, R., Clark, C., Trojanowski, J.Q., Montine, T.J. Empiric Refinement of the Pathologic Assessment of Lewy Related Pathology in the Dementia Patient. Submitted 2007.
• Trojanowski, J.Q., Duff, K., Fillit, H., Koroshetz, W., Murphy, D., Refolo, L., Kuret, J. New directions for frontotemporal dementia drug discovery. Alzheimer’s & Dementia, Submitted 2007.
• Garbern, J.Y., Neumann, M., Trojanowski, J.Q., Lee, V.M.-Y., Schwartz, C., Stevenson, R., Feldman, G., Krajewski, K.M., Kupsky, W., Sima, A.A.F. X-linked mental retardation with tauopathy resembling corticobasal degeneration. Submitted 2007.
• Trojanowski, J.Q., Hendricks, J.C., Jedrziewski, M.K., Johnson, B., Michel, K.E., hess, R.S., Cancro, M.P., Sleeper, M.M., Pignolo, R., Teff, K.L., Aguirre, G.D., Lee, V.M.-Y., Lawler, D.F., Pack, A.I., Davies, P.F., Bain, L.J. Exploring Human/Animal Intersections: Converging Lines of Evidence in Comparative Models of Aging. Submitted 2007.
• Shaw, L.M., Vanderstichele, H., Knapik-Czajka, M., Blennow, K., Soares, H., Simon, A., Lewczuk, P., Dean, R., Lee, V.M.-Y., and Trojanowski, J.Q. Validation of the xMAP multiplex platform and performance of INNO-BIA AlzBio3 for quantification in CSF of Aβ1-42, total tau and p-Tau181p. Submitted, 2007.
• Grossman, M., Xie, S.X., Libon, D.J., Wang, X., Massimo, L., Moore, P. Vesely, L., Berkowitz, R., Chatterjee, A., Coslett, H.B., Hurtig, H.I., Forman, M.S., Lee, V.M.-Y., and Trojanowski, J.Q. Longitudinal decline in autopsy-defined frontotemporal dementia. Ann. Neurol. Submitteed, 2007.
• Winton, M.J., Van Deerlin, V.M., Ignaz, L.M., Kwong, L.K., Schellenberg, G.D., Neumann, M., Miller, B.I., Clark, C.M., Mccluskey, L.F., Ellman, L., Grossman, M.,  Trojanowski, J.Q., and Lee, V.M.-Y. Sequestration and clearance of nuclear TDP-43 as insoluble cytoplasmic aggregates: A pathogenic mechanism in frontotemporal dementia and amyotrophic lateral sclerosis, Nature, Submittted, 2007.
• Chen, X.-H., Johnson, V.E., Graham, D.I., Uryu, K., Trojanowski, J.Q., and Smith, D.H. A lack of amyloid β plaques despite persistent accumulation of amyloid β in axons of long-term survivors of traumatic brain injury. Submitted, 2007.
• Geser, F., Brandmeir, N.J., Kwong, L.K., Martinez-Lage, M., Elman, L., McCluskey, L., Xie, S.X., Lee, V.M.-Y., Trojanowski, J.Q. Amyotrophic lateral sclerosis is a multiple system TDP-43 proteinopathy. Submitted 2007
• Neumann, M., Uryu, K., Kwong, L., Kretzschmar, H., Grossman, M., Clark, C., Miller, B., Lee, V.M.-Y., Trojanowski, J.Q. Concomitant TDP-43 pathology is present in Alzheimer’s disease and corticobasal degeneration but not in other tauopathies. Submitted to J Neuropath & Exper Neuro 2007.
• Gilman, S. Wenning, G.K., Low, P.A., Brooks, D., Mathias, C.J., Trojanowski, J.Q., Wood, N., Colosimo, C., Durr, A., Fowler, C., Kaufmann, H., Klockgether, T., Lees, A., Poewe, W., Quinn, N., Revesz, T., Robertson, D., Sandroni, P., Seppi, K., Vidailhet, M. Second consensus statement on the diagnosis of multiple system atrophy. Neurol., Submitted, 2007.
• Uryu, K., Chen, X.-H., Martinez, D., Browne, K.D., Johnson, V.E., Graham, D.I., Lee, V. M.-Y., Trojanowski, J.Q., and Smith, D.H. Multiple proteins implicated in neurodegenerative diseases accumulate in axons shortly after brain trauma in humans. Exper Neurol 208:185-192, 2007.
• Neumann, N., Kwong, L., Sampathu, D., Trojanowski, J.Q., Lee, V.M.-Y. Basic Science Seminar in Neurology: TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: Protein misfoldiing diseases without amyloidosis. Arch Neurol 64:1388-1394, 2007.
• Luk, K.C., Hyde, E.G., Trojanowski, J.Q., Lee, V.M.-Y. Sensitive Fluorescence Polarization Technique for Rapid Screening of Alpha-Synuclein Oligomerization/Fibrillization Inhibitors. Biochemistry 46:12522-12529, 2007.
• Trojanowski, J.Q. and Revesz, T. for the Neuropathology Working Group on MSA. Proposed neuropathological criteria for the post-mortem diagnosis of multiple system atrophy. Neuropath & Applied Neurobio 33:615-620, 2007.
• Forman, M.S., Trojanowski, J.Q., Lee, V.M.-Y. TDP-43: A Novel Neurodegenerative Proteinopathy. TDP-43: a novel neurodegenerative proteinopathy. Curr Opin Neurobiol 17:548-555, 2007.
• Ballatore, C., Hyde, E., Deiches, R.F., Lee, V.M.-Y., Trojanowski, J.Q., Huryn, D., Smith III, A.B. Paclitaxel C10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies. Bioorg Med Chem Lett 17:3642-3646, 2007.
• Van Deerlin, V.M., Wood, E.M., Moore, P., Yuan, W., Forman, M.S., Clark, C.M., Neumann, M., Kwong, L.K., Trojanowski, J.Q., Lee, V.M.-Y., Grossman, M. Clinical, Genetic, and Pathological Characteristics of Patients with Frontotemporal Dementia and Progranulin Mutations. Arch Neurol 64:1148-1153, 2007.
• Grossman, M., Wood, E.M., Moore, P., Neumann, M., Kwong, L., Forman, M.S., Clark, C.M., McCluskey, L.F., Miller, B.L., Lee, V.M.-Y., Trojanowski, J.Q. TDP-43 Pathologic Lesions and Clinical Phenotype in Frontotemporal Lobar Degeneration with Ubiquitin-Positive Inclusions. Arch Neurol 64:1449-1454, 2007.
• Grossman, M., Libon, D.J., Forman, M.S., Massimo, L., Wood, E.M., Moore, P., Anderson, C., Farmer, J., Chatterjee, A., Clark, C.M., Coslett, H.B., Hurtig, H.I., Lee, V.M.-Y., and Trojanowski, J.Q. Distinct antemortem profiles in pathologically defined patients with frontotemporal dementia, Arch. Neurol., 64:1601-1609, 2007.
• Crowe, A., Ballatore, C., Hyde, E., Trojanowski, J.Q., Lee, V.M.-Y. High Throughput Screening for Small Molecule Inhibitors of Heparin-Induced Tau Fibril Formation. Biochem Biophys Res Commun 358:1-6, 2007.
• Mackenzie, I.R.A., Bigio, E.H., Ince, P.G., Geser, F., Neumann, M., Cairns, N.J., Kwong, L.K., Forman, M.S., Ravits, J., Stewart, H., Eisen, A., McClusky, L., Kretzschmar, H.A., Monoranu, C.M., Highley, R., Kirby, J., Siddique, T., Shaw, P.J., Lee, V.M.-Y., Trojanowski, J.Q. Pathological TDP-43 distinguishes sporadic ALS from ALS with SOD1 mutations. Ann Neurol 61:427-434, 2007.
• Nakashima-Yasuda, H., Uryu, K., Robinson, J., Xie, S.X., Hurtig, H., Duda, J., Arnold, S., Siderowf, A., Grossman, M., Leverenz, J.B., Lopez, O.L., Hamilton, R., Tsuang, D.W., Galasko, D., Masliah, E., Kaye, J., Woltjer, R., Clark, C., Montine, T.J., Lee, V.M.-Y., Trojanowski, J.Q. Co-morbidity of TDP-43 Proteinopathy in Lewy Body Related Diseases. Acta Neuropathol 114:221-229, 2007.
• Cairns, N.J., Neumann, M., Bigio, E.H., Holm, I.E., Troost, D., Hatanpaa, K.J., Foong, C., White III, C.L., Schneider, J.A., Kretzschmar, H.A., Carter, D., Taylor-Reinwald, L, Paulsmeyer, K., Strider, J., Gitcho, M., Goate, A.M., Morris, J.C., Mishra, M., Kwong, L.K., Stieber, A., Xu, Y., Forman, M.S., Trojanowski, J.Q., Lee, V.M.-Y., Mackenzie, I.R.A. TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions. Am J Pathol 171:227-240, 2007.
• Cairns, N.J., Bigio, E.H., Mackenzie, I.R.A., Neumann, M., Lee, V.M.-Y., Hatanpaa, K.J., White III, C.L., Schneider, J.A., Grinberg, L.T., Halliday, G., Duyckaerts, C., Lowe, J.S., Holm, I.E., Tolnay, M., Okamoto, K., Yokoo, H., Murayama, S., Woulfe, J., Munoz, D.G., Dickson, D.W., Ince, P.G., Trojanowski, J.Q., Mann, D.M.A. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol 114:5-22, 2007.
• Ballatore, C., Hyde, E., Deiches, R.F., Lee, V.M.-Y., Trojanowski, J.Q., Huryn, D., and Smith, A.B., III. Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies. Bioorg Med Chem Lett. 17:3642-3646, 2007.
• Murray, R., Neumann, M., Forman, M.S., Farmer, J., Massimo, L., Rice, A., Miller, B.L., Johnson, J.K., Clark, C.M., Hurtig, H.I., Gorno-Tempini, M.L., Lee, V.M.-Y., Trojanowski, J.Q., Grossman, M. Cognitive and Motor Assessment in Autopsy-Proven Corticobasal Degeneration. Neurology 68:1274-1283, 2007.
• Neumann, M., Igaz, L.M., Kwong, L.K., Nakashima-Yasuda, H., Kolb, S.J., Dreyfuss, G., Kretzschmar, H.A., Trojanowski, J.Q., Lee, V.M. Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration. Acta Neuropathol 113:543-548, 2007.
• Roy, S., Winton, M.J., Black, M.M., Trojanowski, J.Q., Lee, V.M.-Y. Rapid and intermittent co-transport of slow component-b proteins. J Neurosci 27:3131-3138, 2007.
• Kim, E.J., Rabinovici, G.D., Seeley, W.W., Halabi, C., Shu, H., Weiner, M.W., Dearmond, S.J., Trojanowski, J.Q., Gorno-Tempini, M.L., Miller, B.L., Rosen, H.J. Patterns of MRI atrophy in tau-positive and ubiquitin-positive frontotemporal lobar degeneration. J Neurol Neurosurg Psychiatry, 78:1375-1378, 2007.
• Neumann, M., Kwong, L.K., Truax, A.C., Vanmassenhove, B., Kretzschmar, H.A., Van Deerlin, V.M., Clark, C.M., Grossman, M., Miller, B.L., Trojanowski, J.Q., Lee, V.M.-Y. TDP-43 positive White Matter Pathology in Frontotemporal Lobar Degeneration with Ubiquitin-Positive Inclusions. J Neuropathol Exp Neurol 66:177-183, 2007.
• Forman, M.S., Mufson, E., Leurgans, S., Pratico, D., Joyce, S., Leight, S., Lee, V. M.-Y., and Trojanowski, J.Q. Cortical biochemistry in MCI and Alzheimer’s disease: lack of correlation with clinical diagnosis. Neurology 68:757-763, 2007.
• Brito, C., Escrevente, C., Reis, C.A., Lee, V.M.-Y., Trojanowski, J.Q., Costa, J. Increased levels of fucosyltransferase IX and carbohydrate Lewis(x) adhesion determinant in human NT2N neurons. J Neurosci Res 85:1260-1270, 2007.
• Van Deerlin, V.M., Forman, M.S., Farmer, J.M., Grossman, M., Joyce, S., Crowe, A., Trojanowski, J.Q., Lee, V.M.-Y., Chatterjee, A. Biochemical and pathological characterization of frontotemporal dementia due to a Leu266Val mutation in microtubule-associated protein tau in an African American individual. Acta Neuropathol 113:471-479, 2007.
• Myers, A.J., Pittman, A.M., Zhao, A.S., Rohrer, K., Kaleema, M., Marlow, L., Lees, A., Leung, D., McKeith, I.G., Perry, R.H., Morris, C.M., Trojanowski, J.Q., Clark, C., Karlawsih, J., Arnold, S., Forman, M.S., Van Deerlin, V., de Silva, R., Hardy, J. The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Neurobiol Dis 25:561-570, 2007.
• Norris, E.H., Uryu, K., Leight, S., Giasson, B.I., Trojanowski, J.Q., and Lee, V.M.-Y. Oxidative damage by paraquat exacerbates neuropathology in an A53T transgenic mouse model of alpha-synucleinopathy. Am. J. Pathol., 170:658-666, 2007.
• Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-U., Iwata, N., Saido, T.C., Maeda, J., Suhara, T., Trojanowski, J.Q., Lee, V.M.-Y. Synapse Loss and Microglial Activation are Early Manifestation of Taupathy in a P301S Mutant Tau Transgenic Mouse Model. Neuron 53:337-351, 2007.
• Giasson, B.I., Covy, J.P., Bonini, N.M., Hurtig, H.I., Farrer, M.J., Trojanowski, J.Q., Van Deerlin, V.M. Biochemical and Pathological Characterization of Lrrk2. Ann Neurol 59:315-322, 2006.
• Dabir, D.V., Robinson, M.B., Swanson, E., Zhang, B., Trojanowski, J.Q., Lee, V.M.-Y., Forman, M.S. Impaired glutamate transport in a mouse model of tau pathology in astrocytes. J Neurosci 26:644-654, 2006.
• Lee, E.B., Leng, L.Z., Zhang, B., Kwong, L., Trojanowski, J.Q., Able, T., Lee, V.M. Targeting Amyloid-beta Peptide (Abeta) Oligomers by Passive Immunization with a Conformation-selective Monoclonal Antibody Improves Learning and Memory in Abeta Precursor Protein (APP) Transgenic Mice. J Biol Chem 281:4292-4299, 2006.
• Uryu, K., Richter-Landsberg, C., Welch, W.J., Sun, E., Goldbaum, O., Norris, E.H., Pham, C.-T., Yazawa, I., Bonini, N., Hilburger, K., Micsenyi, M., Giasson, B.I., Bonini, N.M., Lee, V.M.-Y., Trojanowski, J.Q. Convergence of HSP90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. Am J Pathol 168:947-961, 2006.
• Forman, M.S., Farmer, J., Johnson, J.K., Clark, C.M., Arnold, S.E., Coslett, H.B., Chatterjee, A., Hurtig, H.I., Karlawish, J.H., Rosen, H., Van Deerlin, V., Lee, V.M.-Y., Miller, B.L., Trojanowski, J.Q., Grossman, M. Frontotemporal Dementia: Clinicopathological Correlations. Ann Neurol 59:952-962, 2006.
• Winton, M., Joyce, S., Zhukareva, V., Pratico, D., Perl, D.P., Galasko, D., Craig, U., Trojanowski, J.Q., Lee, V. M.-Y. Characterization of Tau Pathologies in Grey and White Matter of Guam Parkinsonism-Dementia Complex. Acta Neuropathol 111:401-412, 2006.
• Liang, T.W., Truax, A.C., Trojanowski, J.Q., Lee, V.M.-Y., Stern, M.B., Kotzbauer, P.T. Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation. Mov Disord 21:718-722, 2006.
• Goker-Alpan, O., Giasson, B., Elban, M.J., Nguyen, J., Hurtig, H.I., Lee, V.M.-Y., Trojanowski, J.Q., Sidransky, E. Glucocerebrosidase Mutations are an Important Risk Factor for Lewy Body Disorders. Neurology 67:908-910, 2006.
• Liu, K., Solano, I., Mann, D., Lemere, C., Mercken, M., Trojanowski, J.Q., Lee, V.M.-Y. Characterization of Abeta11-40/42 Peptide Deposition in Alzheimer’s Disease (AD) and Young Down Syndrome Brains: Implication of N-terminally Truncated Abeta Species in the Pathogenesis of AD. Acta Neuropathol 112:163-174, 2006.
• Zhukareva, V., Joyce, S., Schuck, T., Van Deerlin, V., Hurtig, H., Albin, R., Gilman, S., Chin, S., Miller, B., Trojanowski, J.Q., Lee, V.M.-Y. Unexpected Abundance Of Pathological Tau In PSP White Matter. Ann Neurol 60:335-345, 2006.
• Sampathu, D.M., Neumann, M., Kwong, L.K., Chou, T.T., Micsenyi, M. Truax, A., Bruce, J., Grossman, M., Trojanowski, J.Q., Lee, V.M.-Y. Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies. Am J Pathol 169:1343-1352, 2006.
• Neumann, M., Sampathu, D.M., Kwong, L.K., Truax, A., Miscenyi, M., Chou, T.T., Bruce, J., Schuck, T., Grossman, M., Clark, C., Mccluskey, L., Miller, B.L., Masliah, E., MacKenzie, I.R., Feldman, H., Feiden, W., Kretzschmar, H.A., Trojanowski, J.Q., Lee, V.M.-Y. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 314:130-133, 2006.
• Fan, Y., Limprasert, P., Murray, I.V.J., Smith, A.C., Lee, V.M.-Y., Trojanowski, J.Q., Sopher, B.L., La Spada, A.R. Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression. Hum Mol Genet 15:3002-3011, 2006.
• Clark, C.M., Pratico, D., Shaw, L.M., Leight, S., Xie, S.X., Gu, A. Lee, V.M.-Y., Trojanowski, J.Q. Commentary on “Optimal design of clinical trials for drugs designed to slow the course of Alzheimer’s disease." Biochemical biomarkers of late-life dementia. Alzheimer’s & Dementia 2:287-293, 2006.
• Schenk, D., Carrillo, M.C., and Trojanowski, J.Q. Perspective: Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery. Alzheimer’s & Dementia: J. Alzheimer’s Assoc., 2:275-281, 2006.
• Borthakur, A., Gur, T., Wheaton, A.J., Corbo, M., Trojanowski, J.Q., Lee, V.M.-Y., Reddy R. In vivo Measurement of Plaque Burden in a Mouse Model of Alzheimer’s Disease. J Magnetic Resonance Imaging 24:1011-1017, 2006.
• Beal, M.F., Bossy-Wetzel, E., Finkbeiner, S., Fiskum, G., Giasson, B., Johnson, C., Khachaturian, Z.S., Lee, V.M.-Y., Nicholls, D., Reddy, H., Reynolds, I., Teplow, D.B., Thal, L.J., Trojanowski, J.Q., Walsh, D.M., Wetzel, R., Wexler, N.S., Young, A.B. Common treads in neurodegenerative disorders of aging. Alzheimer’s & Dementia: J. Alzheimer’s Assoc., 2:322-326, 2006.
• Trachtenberg, D.I. and Trojanowski, J.Q. Dementia: A Word to be Forgotten. Arch of Neurol, In press, 2007.
• Myers, A.J., Pittman, A.M., Zhao, A.S., Rohrer, K., Kaleem, M., Marlowe, L., Lees, A., Leung, D., Morris, C.M., Trojanowski, J.Q., Clark, C., Karlawish, J., Arnold, S., Van Deerlin, V., de Lilva, R., Hardy, J. The H1C risk haplotype of the MAPT locus is associated with increased expression of both total MAPT and 4 repeat containing transcripts. Submitted 2006.
• Luk, K.C., Hyde, E.G., Trojanowski, J.Q., Lee, V.M.-Y. Novel Tools for Parkinson’s Disease Drug Discovery: A Sensitive Fluorescence Polarization Technique for Rapid Screening of Alpha-Synuclein Oligomerization/Fibrillization Inhibitors. Submitted 2006.
• Gao, H.-M., Kotzbauer, P.T., Uryu, K., Trojanowski, J.Q., Lee, V.M.-Y. Neuroinflammation and Oxidation/Nitration of Alpha-synuclein Linked to Dopaminergic Neurodegeneration. J Neuro, in press 2006.

 

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