About Neurodegenerative Diseases
Neurodegenerative diseases share many common pathways and mechanisms, making the coordinated study of these diseases both necessary and highly productive. The components of CNDR research programs are linked into a unified conceptual framework by the hypothesis that "diverse neurodegenerative diseases arise from 'fatal attractions' of brain proteins."
CNDR has created disease overviews for those major diseases being explored at CNDR.
Primary Lateral Sclerosis (PLS)
other Motor Neuron Diseases
Frontotemporal Disease with Parkinsonism (FTDP-17)
Research Overviews of Interest:
- "Neurodegenerative Diseases: New Concepts of Pathogenesis and Their Therapeutic Implications" by Daniel M. Skovronsky, Virginia M.-Y. Lee, and John Q. Trojanowski. (2006) 1:151-170. pdf file: 457KB; from 2006: Annual Review of Pathology: Mechanisms of Disease
- TDP-43 and its role in ALS
- APP and Beta-Amyloid
- Tau / Synuclein
- Dr. Trojanowski’s Lecture on Clash Of The Titans! Convergence of Tau And Alpha-Synuclein Amyloid In Neurodegenerative Diseases