Perelman School of Medicine at the University of Pennsylvania

Center for Neuromodulation in Depression and Stress (CNDS)

Alzheimer's Disease Prevention

Principal Investigator: Yvette Sheline, M.D (NIH funded)

Alzheimer’s disease is a devastating illness with no currently proven effective preventive therapies. This two-year, federally funded study seeks to investigate the effect of taking a certain types of antidepressant medication, Selective Serotonin Reuptake Inhibitors (SSRIs), on the production of a certain type of protein in the brain that is associated with Alzheimer’s disease, known as an Amyloid Beta protein (Aβ).


Who we are looking for:

  • English speaking, right-handed adults, ages 60-85 with no history of neurological injury or disease
  • People with no history of neurological injury or disease
  • People with no current or recent past history of antidepressant use

What you will do:

  • Office visits over 3 months, including cognitive testing, 2 spinal taps, 1 blood draw 
  • Take an antidepressant or placebo for 2-8 weeks and be assessed for biological changes
  • Receive compensation!

If you are interested in participating or would like more information, you can take this brief survey or contact the CNDS: