Perelman School of Medicine at the University of Pennsylvania

Center for Neuromodulation in Depression and Stress (CNDS)

CCBT Depression Treatment Study

PI: Dr. Yvette Sheline, MD (NIH Funded)

Computer-augmented cognitive behavioral therapy (CCBT) is approved by the FDA as a form of treatment for depression. The purpose of the study is to learn more about computer-augmented cognitive behavioral therapy (CCBT) and to examine connections in the brains of patients with depression.

Who are we looking for?

  • Individuals ages 18-60 years old, with OR without symptoms of depression
  • Individuals who have a smart phone (iPhone or Android) and access to a private computer or electronic tablet

What you will do:

  • Clinical interview and self-report questionnaires
  • Complete 1-3 MRI scans
  • Study participation will last approximately 8-20 weeks, depending on study group
  • All participants with depression will complete 9 computer modules of CCBT and meet with a cognitive behavioral therapist 6 times over the course of the study
  • Compensation is provided. 

Who should I contact?

If you are interested, please take this online survey to see if you qualify:

If you would like more information, contact the CNDS at 215-573-2637 or email us at