Perelman School of Medicine at the University of Pennsylvania

Center for Neuromodulation in Depression and Stress (CNDS)

Functional Connectomics of Anxious Misery

PI: Dr. Yvette Sheline (NIH Funded)

Every year more than 30% (2 billion) of the world's population and 75 million adult Americans suffer from disorders that can be described by the term "anxious misery." Although these conditions traditionally have been separated by psychiatric diagnoses, there is much overlap and high rates of co-occurence.

Who should participate?

  • Adults 18-45
  • Individuals who have been diagnosed with depression, anxiety, bipolar II, or PTSD

What will I be doing?

You will attend 2 study visits at the University of Pennsylvania & do at-home monitoring for about 1 week.

You will complete:

  • Clinical interviews and assessments, including self-report questionnaires about your thoughts, feelings, and mood
  • Computerized cognitive assessments
  • Functional MRI scans
  • 1 week of activity and mood monitoring at home

The total time requirement for this study is approximately 8 hours. Participants will receive financial compensation.

Who should I contact?

If you are interested in participating or would like more information concerning our studies, please contact the CNDS:

Fill out a survey at: